Finished

International

EMP – European Microkelvin Platform
Europská Mikrokelvinová Platforma
Program:	Horizon 2020
Project leader:	RNDr. Skyba Peter, DrSc.
Project webpage:	https://emplatform.eu/
Duration:	1.1.2019 – 31.12.2023

ASPIS – Feasibilitystudy of data-drivenAutonomousService forPredictionof IonosphericScintillations(ASPIS)
Feasibilitystudy of data-drivenAutonomousService forPredictionof IonosphericScintillations(ASPIS)
Program:	European Space Agency (ESA)
Project leader:	RNDr. Mackovjak Šimon , PhD.
Duration:	1.1.2022 – 31.12.2023

PURPLEGAIN – Fundamentals and application of purple bacteria biotechnology for resource recovery from waste
Fundamentals and application of purple bacteria biotechnology for resource recovery from waste
Program:	COST
Project leader:	RNDr. Pudlák Michal, CSc.
Duration:	1.1.2022 – 31.12.2023

ANOMATY – Interactions of nanoparticles with amyloid fibrils: from therapy to nanomaterials
Interakcie amyloidných fibríl a nanočastíc pre biomedicínske, biochemické a inžinierske aplikácie
Program:	Bilateral – other
Project leader:	doc. RNDr. Gažová Zuzana, DrSc.
Annotation:	Nanoparticles represent a powerful platform with a large potential for biomedicine and engineering applications.The formation of amyloid aggregates is unfavorable in vivo as they are associated with the pathogenesis of many human diseases, yet, amyloid fibrils have the potential to be engineered into novel materials. However, there is still little known about the interactions between amyloid fibrils and nanoparticles that can provide new enhanced NPs functions. The project aims to investigate the interaction of amyloid fibrils formed from native globular proteins and nanoparticles to utilize or enhance the NPs applications as catalysts in engineering applications or possible disaggregation agents to treat amyloid-related diseases (Alzheimer´s disease, diabetes mellitus). We will determine the relationship between amyloid fibrils (formed from lysozyme, insulin, and α -lactalbumin) and Au-, Ag- and Pd –nanoparticles with different surface chemistry (size, charge, functionalization). Moreover, we will perform a systematic study of globular proteins\’ propensity to form amyloid fibrils with controlled properties. The proposed objectives will be achieved by combining experimental techniques with computational methods routinely used in respective scientific teams. Moreover, the data about fibrils\’ structural and physico-chemical properties might fill the empty spaces in a big biology puzzle – pathophysiology of amyloid-related diseases.
Duration:	1.1.2022 – 31.12.2023

Self assembly and functionalization of nanofibrillar DNA-spider silk hybrid materials
Self assembly and functionalization of nanofibrillar DNA-spider silk hybrid materials
Program:	Inter-academic agreement
Project leader:	RNDr., Ing. Šipošová Katarína, PhD.
Duration:	1.1.2022 – 31.12.2023

SIREN – Space Ionizing Radiation Experts Nursery
Space Ionizing Radiation Experts Nursery
Program:	European Space Agency (ESA)
Project leader:	Mgr. Langer Ronald
Duration:	1.1.2022 – 31.12.2023

SK-S2P-Edu – Proposal for Slovak universities curriculum adaptation toward S2P market (SK-S2P-Edu)
Proposal for Slovak universities curriculum adaptation toward S2P market (SK-S2P-Edu)
Program:	European Space Agency (ESA)
Project leader:	RNDr. Mackovjak Šimon , PhD.
Duration:	1.12.2022 – 31.10.2023

NOVEL COMPOSITES BASED ON CERIUM OXIDE NANOPARTICLES AND CARBON ENTEROSORBENTS FOR ACUTE RADIATION SICKNESS THERAPY
NOVÉ KOMPOZITY NANOČASTÍC OXIDU CÉRIA A UHLÍKOVÝCH ENTEROSORBENTOV PRE LIEČBU CHORÔB PO AKÚTNOM OŽIARENÍ
Program:	NATO
Project leader:	MUDr. Musatov Andrey, DrSc.
Duration:	15.7.2020 – 14.7.2023

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Atmosférické elektrické pole a dynamika nabitých častíc a sekundárne kozmické žiarenie vo vysokých horách
Program:	Inter-academic agreement
Project leader:	RNDr. Mackovjak Šimon , PhD.
Duration:	1.1.2022 – 31.12.2022

Atmospheric electric field and dynamics of charged particles and secondary cosmic rays in high mountains
Atmosférické elektrické pole a dynamika nabitých častíc a sekundárneho kozmického žiarenia vo vysokých horách
Program:	Mobility
Project leader:	Mgr. Langer Ronald
Duration:	1.1.2021 – 31.12.2022

AMAZON – –
Dynamické štúdium amyloidnej agregácie proteínov pomocou magnetických zeolitových nanočastíc
Program:	JRP
Project leader:	doc. RNDr. Kopčanský Peter, CSc.
Duration:	1.1.2018 – 31.12.2022

Elastic micro-tools for optical manipulation of biological objects
Elastic micro-tools for optical manipulation of biological objects
Program:	Inter-academic agreement
Project leader:	doc. Ing. Tomori Zoltán, CSc.
Duration:	1.1.2019 – 31.12.2022

FMF – Flexible Magnetic Filaments: Properties and Applications
Flexibilné magnetické vlákna: Vlastnosti a aplikácie
Program:	ERANET
Project leader:	doc. RNDr. Kopčanský Peter, CSc.
Annotation:	Different technologies for synthesis of flexible magnetic filaments are developed. These include linking magnetic micro-particles by DNA, attaching magnetic nanoparticles to polyelectrolyte bundles, extraction of magnetosomes from magnetotactic bacteria and other. Flexible magnetic filaments are interesting for applications as self-propelling microdevices(for targeted transport), micro-mixers (for microfluidics), different sensors(micro rheology). Numerical algorithms for predicting their behavior in magnetic fields of different configurations will be developed, including algorithms based on curve dynamics, lattice Boltzmann method, Brownian dynamics. Obtained numerical results will be compared with experimental results of measurement of flows fields around magnetic filaments, their buckling instabilities. As a result new technology will be developed for DLS measurements giving access to characteristics of translation and rotational motion of string like magnetic micro-objects.
Duration:	1.9.2018 – 31.12.2022

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JEM-EUSO, Kozmické Observatórium Extrémneho Vesmíru na palube Japonského Experimentálneho Modulu
Program:	European Space Agency (ESA)
Project leader:	RNDr. Bobík Pavol, PhD.
Duration:	1.1.2010 – 31.12.2022

TMQM – Tuning of frustrated metallic quantum magnets
Ladenie frustrovaných kovových kvantových magnetov
Program:	Inter-academic agreement
Project leader:	doc. RNDr. Gabáni Slavomír, PhD.
Duration:	1.1.2021 – 31.12.2022

Point-contact and tunnel spectroscopy of the topological insulator SnTe and Ge semiconductor
Mikrokontaktová a tunelová spektroskopia topologických izolátorov SnTe a Ge polovodičov
Program:	Inter-academic agreement
Project leader:	Mgr. Szabó Pavol, CSc.
Annotation:	Quantum materials with a nontrivial topology of the electronic band structure are in recent years in the forefront of intensive theoretical and experimental studies. This is due not only to their unusual physical properties, but also due to possible applications in the new generation of electronics, in particular in quantum computers and spintronic elements. The key characteristic of these materials is the specific topology of the electronic structure, which defines non-trivial properties of their normal and superconducting state. At present, the efforts of the scientific community are focused on the ability to detect the peculiarities of surface states of these materials in transport measurements.It is believed that nonconventional superconductivity in topological materials (insulators) is realized in surface states. Under the influence of these investigations, a search was initiated and a surface superconducting state was detected in doped elemental semiconductors, which are widespread and technologically attractive. Thus, superconductivity was detected in a semiconductor Si, which has a high critical temperature of up to 10 K, which gives new perspectives in further research and new applications of classical semiconductors.For an efficient search for new compounds with predicted parameters, an understanding of the superconductivity mechanism that is implemented in these compounds is required. It is clear that this requires a thorough study of the characteristic physical properties of topological materials, using various experimental methods, among which tunneling and point-contact spectroscopy occupy one of the key places. Thus, in the joint project it is planned to study comprehensively the physical properties of the proposed objects – semiconductor Ge and the topological isolator SnTe to clarify the nature of their superconducting state. It is planned to conduct surface-sensitive point-contact measurements, where the features of surface states will affect the transport of charge carriers. Properties of surface states make topological materials particularly promising for quantum electronic applications. To find out the nature of the superconducting state, it is necessary to establish a pairing mechanism, which is usually associated with the interaction of two electrons, for example, due to such quasiparticles as phonons in ordinary superconductors. Thus, obtaining information on electron-quasiparticle interaction in the formation of superconducting pairs is very important for understanding the nature of superconductivity. From this point of view, the point-contact spectroscopy is a direct experimental method for obtaining the spectral function of the electron-boson (quasiparticle) interaction, which is responsible for the formation of superconducting pairs.Similar experiments were carried out by Ukrainian and Slovak teams for many types of superconductors. Therefore, taking into account this considerable experience in the project, it is planned to investigate the surface superconducting state in some promising representatives of semiconductors and topological insulators.
Duration:	1.4.2020 – 31.12.2022

Multifunctional magnetic materials – research into structure and physical properties
Multifunctional magnetic materials – research into structure and physical properties
Program:	Inter-academic agreement
Project leader:	RNDr. Zentková Mária, CSc.
Annotation:	The object of the collaboration is investigation of the magnetic, structural and thermodynamic properties ofnew magnetic materials such as manganites, magnetic oxides and molecule-based magnets. Of particularimportance is the search for functional materials with light-, temperature- or pressure-controlled propertiesas well as magnetic molecular nanosystems. Collaboration in this area between the Institute of NuclearPhysics PAS and the Institute of Experimental Physics SAS lasts for over twelve years. We have carried outcommon studies of several molecular magnets, workers of INP PAN take regularly part in the triennialCSMAG conference organized in Košice. We are in possession of different but complementary measurementinstruments. Therefore, the continuation of the joint project, aimed at a more comprehensive description andunderstanding of properties of new magnetic materials, would be purposef
Duration:	19.2.2019 – 31.12.2022

MultiFunMag – Design and preparation of multifunctional magnetic nanoparticles for the cancer cell detection
Návrh a príprava multifunkčných magnetických nanočastíc na detekciu nádorových buniek
Program:	Multilateral – other
Project leader:	Ing. Závišová Vlasta, PhD.
Annotation:	Cancer is the second leading cause of death after cardiovascular disease in almost all European countries. Over the past several decades, the principle types of cancer therapies have been chemotherapy, radiation therapy and surgery. This project is focused on the development of biocompatible multifunctional magnetic nanoparticles and evaluation of their diagnostic andtherapeutic potential for the application in oncology. The first step to achieve the desired goals will be the synthesis of magnetic nanoparticles and the functionalization of their surface with a suitable biocompatible materials suitable for radiotracer binding. Several physicochemical methods will be used to optimize the preparation of biocompatible multifunctional magnetic nanoparticles (MNPs). At the same time, we will study the suitability of multifunctional magnetic nanoparticles for magnetic resonance imaging and magnetic hyperthermia application as well. Considering the application purposes of biocompatible multifunctional magnetic nanoparticles, biodistribution studies of radiotracer conjugated MNPs will be conducted. The prepared radiotracer conjugated MNPs will improve the efficacy of cancer diagnosis and treatment. Moreover, combination of MRI, hyperthermia and radiotherapy represents a significant advance in cancer diseases treatment and a substantial improvement in survival of oncological patients. The project is based on a complex multidisciplinary approach,ranging from physics, chemistry up to biochemistry and biomedicine. The involved partners possess key skills, infrastructure and are highly motivated to reach the project goals.
Duration:	1.3.2020 – 31.12.2022

Ordering and self-organization of magnetic nanoparticles in liquid crystals
Ordering and self-organization of magnetic nanoparticles in liquid crystals
Program:	Inter-academic agreement
Project leader:	RNDr. Lacková Veronika, PhD.
Duration:	1.1.2019 – 31.12.2022

Preparation and study of structural and magnetic properties of core/shell CoFe2O4/Fe3O4 nanoparticles for advanced magnetic hyperthermia
Príprava a štúdium štruktúrnych a magnetických vlastností CoFe2O4/Fe3O4 nanočastíc typu "core/shell" pre magnetickú hypertermiu
Program:	Inter-academic agreement
Project leader:	RNDr. Škorvánek Ivan, CSc.
Duration:	1.1.2020 – 31.12.2022

SK-S2P – Slovakia national Space Safety Programme(S2P) study (SK-S2P)
Slovakia national Space Safety Programme(S2P) study (SK-S2P)
Program:	European Space Agency (ESA)
Project leader:	RNDr. Mackovjak Šimon , PhD.
Duration:	1.12.2021 – 31.12.2022

SIREN – Space Ionizing Radiation Experts Nursery
Space Ionizing Radiation Experts Nursery
Program:	European Space Agency (ESA)
Project leader:	Mgr. Langer Ronald
Duration:	1.1.2020 – 31.12.2022

Stability and aggregation of globular proteins in the presence of biocompatible ionic liquids
Stabilita a agregácia globulárnych proteínov v prítomnosti biokompatibilných iónových kvapalín
Program:	Mobility
Project leader:	RNDr. Fedunová Diana, PhD.
Duration:	1.1.2021 – 31.12.2022

Tenso-Network States Algorithms and Applications
Stavy tenzorových stietí Algoritmy a aplikácie
Program:	JRP
Project leader:	RNDr. Vargová Hana, PhD.
Duration:	1.1.2021 – 31.12.2022

Investigation of graphene covered superconducting nanostructures by scanning tunneling microscopy
STM štúdium grafénom pokrytých nanoštruktúr
Program:	Inter-academic agreement
Project leader:	Mgr. Szabó Pavol, CSc.
Annotation:	The proposed project represents a continuation of our previous collaboration, which we started in the framework of our common APVV SK-Hu-2013-0039 project „Elaboration and characterization of graphene layers with controlled nanoscale rippling” in 2015. In this project, we have studied the physical properties of tin/graphene hybrid nanostructures applying low temperature STM microscopy and spectroscopy. We have shown, that the graphene cover layer acts as a passivating layer and protects the tin nanoparticles from oxidation. Our low temperature STM results prove that superconductivity is induced in grapheme both, when directly directly supported by tin nanoparticles or suspended among them. These results have been published in our common paper in a prestigious journal Carbon [A. Pálinkás, et al., Carbon 124 (2017) 611-617].
Duration:	1.1.2019 – 31.12.2022

Superconducting properties of boride thin films
Supravodivé vlastnosti tenkých vrstiev boridov
Program:	Mobility
Project leader:	doc. RNDr. Flachbart Karol, DrSc., akademik US Slovenska
Annotation:	The aim of the mobility project is to prepare thin films of superconducting borides YB6 and ZrB12, and to investigate their properties as function of thickness, microstructure and applied pressure.The outcome of this investigation will be new information about how the superconducting properties of bulk (3D) superconductors change when they become two dimensional (2D). In this regard namely a modification of superconducting properties is expected due to a considerable change of rich phonon spectra in borides and of the related electron-phonon interaction, which are responsible for the origin of superconductivity. This research on borides is unexplored, therefore new and original results are expected.The project will, moreover, enable a mutual use of laboratory equipment (for thin film preparation in Leoben, for their investigation in Kosice), it will lead to promotion of post-docs and PhD students, to preparation of common publications, and probably also to further common projects.
Duration:	1.1.2021 – 31.12.2022

Investigation of new ferromagnetic nanocomposites
Štúdium nových feromagnetických nanokompozitov
Program:	Inter-academic agreement
Project leader:	RNDr. Kováč Jozef, CSc.
Duration:	1.1.2019 – 31.12.2022

AMON-net – Follow-up of feasibility study to observe ionospheric disturbances by airglow monitoring network (AMON-net)
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Program:	European Space Agency (ESA)
Project leader:	RNDr. Mackovjak Šimon , PhD.
Duration:	1.10.2018 – 30.9.2022

TESTIMONIES – Theoretical and Experimental Study of Transition Metal Oxyhydride Nanomaterials for Superconductivity and Photocatalysis
Teoretické a experimentálne štúdium nanomateriálov na báze oxyhydridov prechodových kovov pre supravodivosť a fotokatalýzu
Program:	ERANET
Project leader:	doc. RNDr. Flachbart Karol, DrSc., akademik US Slovenska
Duration:	1.10.2019 – 30.9.2022

Nanocohybri – NANOSCALE COHERENT HYBRID DEVICES FOR SUPERCONDUCTING QUANTUM TECHNOLOGIES
NANOSCALE COHERENT HYBRID DEVICES FOR SUPERCONDUCTING QUANTUM TECHNOLOGIES
Program:	COST
Project leader:	prof., RNDr. Samuely Peter, DrSc., akademik US Slovenska
Annotation:	Superconducting technologies are prime candidates to ripen quantum effects into devices and applications. The accumulated knowledge in decades of work in understanding superconductivity allows scientists now to make experiments by design, controlling relevant parameters in devices. A new field is emerging whose final objective is to improve appliances taking advantage of quantum effects, be it for dissipationless transport of current, generation of high magnetic fields, sensors or quantum information. The field will impact crucial areas for societal development, including energy, transport, medicine or computation. Quantum behavior is controlled by using hybrids of superconductors with magnets, insulators, semiconductors or normal metals. Traditionally, the scientific and technical communities working in superconductivity are spread across projects from different calls, whose activities put Europe at the frontier of research. The present Action aims to address the pressing need for a common place to share knowledge and infrastructure and develop new cooperative projects.To this end, we have set-up a program including networking activities with an open, proactive and inclusive approach to other researchers and industry. We will develop the concept of a Virtual Institute to improve availability of infrastructure and knowledge, and focus on contributing to gender balance and the participation of young researchers. The proposal aims to avoid duplication of resources and skills in a subject traditionally dominated by small groups working independently. This will optimize European efforts in this area and uncover our full potential, thus maintaining and developing Europe’s leading position in superconducting quantum technologies.
Duration:	18.10.2017 – 17.4.2022

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Program:	Bilateral – other
Project leader:	Ing. Baláž Ján, PhD.,
Duration:	– 1.3.2022

The ALICE experiment at the CERN LHC: Study of the strongly interacting matter under extreme conditions
Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach
Program:	CERN
Project leader:	RNDr. Králik Ivan, CSc.
Annotation:	The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties.
Project webpage:	//http://osf.saske.sk/sk/?id=vyskum&sub=experimenty_ALICE
Duration:	1.1.2021 – 31.12.2021

ATLAS experiment on LHC at CERN: deep-inelastic precesses and new physics at TeV energies
Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách
Program:	CERN
Project leader:	RNDr. Stríženec Pavol, CSc.
Project webpage:	http://osf.saske.sk/sk/?id=vyskum&sub=experimenty_ATLAS
Duration:	1.1.2021 – 31.12.2021

JEM-EUSO – JEM-EUSO, Extreme Universe Space Observatory Onboard Japan Experiment Module
JEM-EUSO, Kozmické Observatórium Extrémneho Vesmíru na palube Japonského Experimentálneho Modulu
Program:	European Space Agency (ESA)
Project leader:	RNDr. Bobík Pavol, PhD.
Annotation:	Research of extreme energy cosmic rays with use of observations of secondary responses in the atmosphere of Earth from the International space station
Project webpage:	http://jem-euso.roma2.infn.it
Duration:	1.1.2010 – 31.12.2021

CAMBIOMN – Complementary analytic methods for the determination of the biodistribution of the magnetic nanoparticles
Komplementárne analytické metódy na určenie biodistribúcie magnetických nanočastíc
Program:	Bilateral – other
Project leader:	Ing. Koneracká Martina, CSc.
Annotation:	The main objective of the proposed project is focused on the design and synthesis of magneticnanoparticles as a potential candidate for hyperthermia, transport delivery and chemotherapy/radiotherapytreatment. The special effort is devoted to their biodistribution investigation due to the combination ofcomplementary physico-analytical methods. Basic concept includes procedures (i) to obtain well-definedmagnetic nanoparticles available for medical applications, (ii) to characterize the products under welldefinedand reproducible conditions, (iii) to develop proper combination of physico-analytical methodstowards detailed biodistribution analyses. In the context of the proposed project, special effort will befocused on the systematic study of the optimization of magnetic nanoparticles synthesis with suitablefunctional properties and sufficient response to the selected analytical methods for determination of theirbiodistribution. It is expected that such attitude will result in protocol for preparation and studybiodistribution of magnetic nanoparticles in as low as possible concentrations that could significantlydecrease undesirable side effects of treatment. Besides that, such project will significantly contribute to the(i) bilateral cooperation and transfer of knowledge between experts in chemistry, physics, biology andpharmacy; (ii) the optimization of the real structure and bioaccumulation investigation of the preparedproducts; (iii) presentation and publication of common results on high impact factor journals and important international conferences; (iv) networking/base for further cooperation in highly attractive scientific fieldregarding biophysics/nanomedicine.
Duration:	1.1.2019 – 31.12.2021

MAGBIO – Magnetic nanocomposites for biomedicine
Magnetické nanokompozity pre biomedicínu
Program:	Bilateral – other
Project leader:	RNDr. Zentková Mária, CSc.
Annotation:	Multidisciplinary project is devoted to synthesis and characterization of magnetite and manganite based magnetic nanocomposites with application potential for hyperthermia. Magnetic nanoparticles produced by various synthetic routes will be functionalized by methods of surface chemistry and tested for amount of the heat loss in the presence of alternating current magnetic field at frequencies and amplitudes causing no harm to patients. Aspects of biocompatibility and nontoxicity of prepared nanocomposites will be studied as well.
Duration:	15.2.2019 – 31.12.2021

MAGSAT – Novel soft magnetic cores tailored for use in space qualified magnetometers and satellite devices
Nové magneticky mäkké jadrá pre satelitné zariadenia a magnetometre pracujúce v kozmických podmienkach.
Program:	JRP
Project leader:	RNDr. Škorvánek Ivan, CSc.
Duration:	1.9.2018 – 31.12.2021

Ordering and self-organization of magnetic nanoparticles in liquid crystals
Usporiadanie a samoorganizácia magnetických nanočastíc v kvapalných kryštáloch
Program:	Inter-academic agreement
Project leader:	RNDr. Lacková Veronika, PhD.
Duration:	1.1.2019 – 31.12.2021

Enhancement of Bioactivity of Cerium Oxide Nanoparticles
Zvýšenie Bioaktivity Nanočastíc Oxidu Céria
Program:	Inter-academic agreement
Project leader:	MUDr. Musatov Andrey, DrSc.
Duration:	1.1.2020 – 31.12.2021

NANOConVEX CIG – – Nanofluids for convective heat transfer devices NANOConVEX CIG
Nanokvapaliny pre zariadenia na prenos tepla prúdením NANOConVEX CIG
Program:	COST
Project leader:	RNDr. Timko Milan, CSc.
Annotation:	In this project we would like to use the obtained results and experiences in application magnetic nanofluids prepared by our group in high power transformers with the intention of lowering of working temperature, increasing of heat dissipation from the transformer core at preservation its insulation characteristics. This fact will have the influence on the lifetime and lowering the cost reduction during the operation.
Duration:	1.5.2020 – 30.4.2021

MAGBBRIS – New MAGnetic Biomaterials for Brain Repair and Imaging after Stroke
Nové magnetické biomateriály pre obnovu mozgu a zobrazovanie po mozgovej príhode
Program:	ERANET
Project leader:	doc. RNDr. Kopčanský Peter, CSc.
Annotation:	By engineering novel magnetic nano-biomaterials we will achieve tissue repair in the context of an ischemic event. We will take advantage of nanotechnology to deliver therapeutic growth factors, secreted by progenitor cells, into the injured brain.According to the World Health Organization, 15 million persons suffer a stroke worldwide eachyear. However, the only available treatment is the acute thrombolytic therapy (pharmacological or mechanical) which is being administered to less than 10% of stroke patients due to strict selectioncriteria. In contrast, neuro-repair treatments could offer the opportunity to include most strokepatients by extending the therapeutic time window.MAGBBRIS will demonstrate that growth factors, secreted by endothelial progenitor cells, with proved potential to induce tissue repair, can be encapsulated in magnetic biomaterials and be successfully and safely transplanted into mouse brains to induce tissue repair. In the ischemic brain, the secretome will be retained by an external magnetic field in the vasculature, improving vascular remodelling and neurogenic tissue regeneration after stroke.
Duration:	1.3.2018 – 28.2.2021

Atmospheric electricity and secondary cosmic radiation
Atmosferická alektrina a sekundárne kozmické žiarenie
Program:	Inter-academic agreement
Project leader:	Mgr. Langer Ronald
Annotation:	A continuation of recently started joint investigation into the relation between atmospheric electricity and dynamics, secondary cosmic radiation and space weather is proposed. A special focus will be paid to events that occur during thunderstorms, e.g., to enhanced count rates that were observed in particle detector SEVAN during periods of large electric fields, and search for a possible detection of particles during individual atmospheric discharges. The study will be based on measurements of electrostatic field, electromagnetic radiation from lightning, meteorological data, and energetic particles and gamma-rays on Lomnický peak. A further improvement and extension of measurement setup around Lomnický peak is anticipated. Atmospheric electric field will also be measured at several places in the Czech Republic. The main goal of the proposed project is a better understanding of mechanisms that couple atmospheric electricity and thunderstorms with energetic particles (radiation) and space weather. Both statistical approach and analysis of individual events will be performed.
Duration:	1.1.2018 – 31.12.2020

AMAZON – Dynamical study of formation/destruction of protein amyloid aggregatess targeted by magnetic zeolite nanocomposites
Dynamické štúdium amyloidnej agregácie proteínov pomocou magnetických zeolitových nanočastíc
Program:	JRP
Project leader:	doc. RNDr. Kopčanský Peter, CSc.
Annotation:	Abnormal protein aggregation and accumulation of formed fibrils are characteristic features for a range of, if not all, neurodegenerative disorders such as Alzheimer’s, Huntington’s, Parkinson’s, as well as non-neuropathic amyloidosis. Nanoparticles (NPs), attributed to its particularities in sizes, chemical composition and surface properties, have already been found effective in influencing amyloid fibrils. Our preliminary results acquired on amyloid fibrils incubated with in-laboratory synthesized Fe3O4 nanoparticles (MNPs) indicated reductive potential of MNPs on formation of amyloid fibrils, and also suggested facilitation of inhibiting preformation and eradication of amyloid fibrils may be plausible when the fibrils are exposed to external radiation in presence of MNPs. Also, with our previously reported photoluminescence properties of natural zeolite (CZ) which is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional ability to adsorb various atoms, organic molecules and nanoparticles into micro- and mesopores, we plan to apply the MNPs with CZ, developing multiphoton excitation microscopy (MPEM), and other appropriate instruments to establish the dynamical investigation of amyloid fibril formation and remodeling in real time. Prior to in vivo experiment, cytotoxicity in different type of cells and animal models such as zebrafish and mice will be evaluated.
Duration:	1.1.2018 – 31.12.2020

ALICE experiment at the CERN LHC: The study of strongly interacting matter under extreme conditions
Experiment ALICE na LHC v CERN: Štúdium silno interagujúcej hmoty v extrémnych podmienkach
Program:	CERN
Project leader:	RNDr. Králik Ivan, CSc.
Annotation:	The project is aimed at the study of strongly interacting matter under extreme conditions of the p-p, p-Pb and Pb-Pb collisions at the energies of the LHC collider at CERN. The main program of the ALICE experimemt is the study of the quark-gluon plasma properties.
Project webpage:	http://osf.saske.sk/sk/?id=vyskum&sub=experimenty_ALICE
Duration:	1.1.2016 – 31.12.2020

ATLAS experiment on LHC in CERN: deep-inelastic events and new physics at TeV energies
Experiment ATLAS na LHC v CERN: hlboko-nepružné javy a nová fyzika pri TeV energiách
Program:	CERN
Project leader:	doc. RNDr. Bruncko Dušan, CSc.
Project webpage:	http://www.saske.sk/UEF/OSF/ATLAS/atlas_1.html
Duration:	1.1.2016 – 31.12.2020

MGFS – Metallic geometrically frustrated systems
Kovové geometricky frustrované systémy
Program:	Inter-academic agreement
Project leader:	doc. RNDr. Gabáni Slavomír, PhD.
Annotation:	The principal aim of this project is to establish the microscopic anisotropy parameters and the relevant terms for the magnetic interaction in MGFS. Despite significant experimental and theoretical work, such parameters are unknown for the compounds (e.g. TmB4, HoB4) which form a Shastry Sutherland lattice (SSL) as well as for the highly symmetric face centered cubic (fcc) lattice based systems (e.g. HoB12). The experimental approach will be magnetisation measurements as a function of field direction, neutron diffraction combined with modelling techniques like WIEN2K, McPhase or SpinW. The oscillatory RKKY exchange interaction parameters are expected to be susceptible to applied pressure as well as to alloying. Suitable methods and oriented samples of rare earth borides are available.Crystal field anisotropy is theoretically described by a multipole expansion of theelectric field. The crystal field level splitting parameters will be determined frommagnetisation and specific heat data, as a function of field direction, as well as frominelastic neutron diffraction on powder samples, typically using software like McPhase.The goal of this part is a description of anisotropy of TmB4, HoB4 and the symmetric fcc– counterparts HoB12 and TmB12.The second set of parameters needed for understanding of the Hamiltonian are themagnetic interactions. They will be determined from the dispersion relationsmeasured using neutron spectroscopy on HoB4 and HoB12 along differentcrystallographic directions and in applied magnetic field. These parameters depend ondetails of the RKKY interaction which as a cross check can also be obtained from firstprinciples, using packages like WIEN2K. This type of experiments will be carried out atthe HZB Berlin on isotopically enrich Ho11B4 and Ho11B12 samples, which are availableand first testing experiments were already carried out.We intend to verify results by high pressure experiments (we assume pressuresup to 10 GPa in diamond pressure cells) which is associated with the increase ofitinerant electron concentration in MGFS, and thus with the change of parameters aswell as changes of critical fields and temperatures. This aim will cover MGFS based onthe SSL structure as well as systems based on the fcc structure. Another option to verifyresults is alloying. We will study the effect of substitution of magnetic ions like Tm3+and Ho3+ ions by nonmagnetic Lu3+ ions. Necessary devices and samples for thisresearch are available.
Duration:	1.1.2019 – 31.12.2020

Cosmic rays as observed at two high mountain observatories: BEO Moussala and Lomnicky Stit
Kozmické žiarenie pozorované na dvoch vysokohorských observatóriách: Moussala a Lomnický štít
Program:	Inter-academic agreement
Project leader:	Mgr. Langer Ronald
Annotation:	The main idea of the project is bilateral cooperation between two European high mountain stations (Lomnický štít, Slovakia and BEO Moussala, Bulgaria) in the field of solar phenomena (or extreme space whether events) as Forbush decrease (FD) and modulation effects on galactic cosmic rays (GCR), and their possible correlation with meteorological parameters. A Forbush decrease is a rapid decrease in the observed galactic cosmic ray intensity following a coronal mass ejection (CME). It occurs due to the magnetic field of the plasma solar wind sweeping some of the GCR away from Earth. The FD is usually observable by particle detectors on Earth within a few dаys аfter the CME, аnd the decrease takes place over the course of a few hours. Over the following severаl dаys, the sоlar cоsmic ray intensity rеturns tо nоrmal.Peer reviewed article (2) from 2009 found that low clouds contain less liquid water following Forbush decreases, and for the most influential events the liquid water in the oceanic atmosphere can diminish by as much as 7%. Further work (3, 4) found no connection between Forbush decreases and cloud properties until the connection was found in diurnal temperature range (5) and since confirmed in satellite data (6).8NM64 neutron monitor measures continuously cosmic rays at Lomnický Štít (2634 m a.s.l., rigidity cut-off ~4GV) with high statistical accuracy (average count rate ~440 s-1) since December 1981 (7).The muon telescope at BEO Moussala (2925 m a.s.l., rigidity cut-off ~6.3 GV) is in operation since August 2006. The averaged yearly data show good anti-correlation with the averaged sun-spot number for the period August 2006 – June 2017 (to be published elsewhere), several FDs were also detected (8, 9 and 10). The CR data from the two stations will be analyzed for 11 years period and correlations between their variations and meteorological parameters will be investigated (11, 12). The effect of strong electric field around the time of the thunderstorms will be searched both at Moussala and at Lomnický štít with help of similar detector systems SEVAN being in operation at both stations as it was done recently for Lomnický štít (15). This may be especially importance because of different shape of surface at the stations (Lomnicky stit is rather sharp in altitude profile). The physics behind climate change is still a subject of discussion and in need of further analysis (13). The standard method of examining the effect of CR on CC is to search for a correlation of the time series of the two quantities: CC and CR (14). There are numbers of factors which need to be kept in mind, as follows: the presence of a correlation between CR and CC; the nature of CC; Global, spatial variability; Global temporal variability;Altitude differences. In what follows we examine the comprehensive meteorological data from the Lomnicky stit (LS) and BEO Moussala mountain observatories in comparison with Global data to answer the question: is there support for the hypothesis that CR contribute significantly to the local climate, by way of enhanced cloud cover?References1. "Extreme Space Weather Events". National Geophysical Data Center.2. "Cosmic ray decreases affect atmospheric aerosols and clouds". Geophys. Res. Lett. 17 June 20093."Atmospheric data over a solar cycle: no connection between galactic cosmic rays and new particle formation".4."Sudden Cosmic Ray Decreases. No change of cloud cover" (PDF).5."Forbush decreases – clouds relation in the neutron monitor era". Astrophys. Space Sci. Trans. 31 August 2011.6. Svensmark, J; Enghoff, M. B.; Shaviv, N; Svensmark, H (September 2016). "The response of clouds and aerosols to cosmic ray decreases". J. Geophys. Res. Space Physics. 121 (9): 8152–8181. Bibcode:2016JGRA..121.8152S. doi:10.1002/2016JA022689. Retrieved June 5, 2017.7. http://www.beo.inrne.bas.bg/BEOBAL/Conf_Pres/111.pdf8. Angelov I., E. Malamova, J. Stamenov, The Forbush decrease after the GLE on 13 December 2006 detected by the muon telescope at BEO – Moussala, Advances in Space Research, 2008, v.43, n.4, p. 504-508, doi:10.1016/j.asr.2008.08.0029. Tchorbadjieff Assen, Christo Angelov , Ivo Angelov , Todor Arsov , Ivo Kalapov, Nina Nikolova, Aneta Boyadjieva, Detection of coronal mass ejections (CMEs) in the period of march–may 2012 at Moussala peak, Comptes rendus de l’Academie bulgare des Sciences (C. R. Acad. Bulg. Sci.) vol 66, No 5, pp. 659-666, 201310. Assen Tchorbadjiev, Ivo Angelov, Christo Angelov, Nina Nikolova, Todor Arsov, Ivo Kalapov, Ani Boyadjieva, “Detection of Solar particle events in March 2012 at Moussala”, Bulgarian Astronomical Journal, 18(2), 2012, http://www.astro.bas.bg/AIJ/issues/n182/08-ATchorbad.pdf11. Jordan Stamenov, Nina Nikolova, Luchezar Georgiev, “Correlation between cosmic rays intensity variation and nitrogen oxides in the atmosphere”, Issue Paradigma, pp. 134-140, 201012. Luchezar Georgiev, Nina Nikolova, Miloslav Katsarov, “Modeling and experimental research in Forbush-effect on the radiation background on the territory of the Republic of Bulgaria”, XI-th National Youth Science Conference, Federation of the Scientific-Engineering Unions in Bulgaria, ISSN: 1314-0698, 2013(13) M. Kancírová, K. Kudela, A.D. Erlykin and A.W. Wolfendale, Relevance of long term time – series of atmospheric parameters at a mountain observatory to models for climate change, Journal of Atmospheric and Solar-Terrestrial Physics, http://dx.doi.org/10.1016/j.jastp.2016.08.002(14) M. Kancírová, K. Kudela, Atmospheric Research 149 (2014) 166–173(15) K Kudela, J. Chum, M. Kollarik, R. Langer, I. Strharsky and J. Base, Correlations between secondary cosmic ray rates and strong electric fields at Lomnicky stit, JGR Atmospheres, accepted September 26, doi: 10.1002/2016JD026439
Duration:	1.1.2018 – 31.12.2020

– – Study of the protein amyloid aggregation in vitro and in cerebrospinal fluid
Štúdium amyloidnej agregácie proteínov in vitro a v mozgomiešnom moku
Program:	Inter-institute agreement
Project leader:	doc. RNDr. Gažová Zuzana, DrSc.
Annotation:	Study of the amyloid aggregation of the protein in vitro and in the samples of the cerebrospinal fluid of the peoples with amyloid-related disease which obtain protein aggregation in vivo.Test of the assay for cerebrospinal fluid of the dementic and non-dementic peoples.
Duration:	13.7.2015 – 31.12.2020

Nanoradiomag – Development and production of water-dispersible radionuclide labeled magnetic nanoparticles
Vývoj a príprava rádionuklidmi značených magnetických nanočastíc dispergovaných vo vodnom prostredí.
Program:	EUREKA
Project leader:	Ing. Koneracká Martina, CSc.
Duration:	1.1.2018 – 31.12.2020

SPACE:LAB – place to attract, educate and involve young generation in space science and engineering
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Program:	European Space Agency (ESA)
Project leader:	RNDr. Mackovjak Šimon , PhD.
Duration:	1.12.2018 – 30.11.2020

NANOUPTAKE – Overcoming Barriers to Nanofluids Market Uptake ( NANOUPTAKE)
Prekonanie bariiér pre komerčné využitie nanokvapalín (NANOUPTAKE)
Program:	COST
Project leader:	RNDr. Timko Milan, CSc.
Annotation:	Nanofluids are defined as fluids that contain nanometre-sized particles with enhanced heat transfer properties. Nanofluids improve the efficiency of heat exchange and thermal energy storage. In addition, nanofluids fall within one of the Key Enabling Technologies (KET) supported by the European Commission. Although some nanofluid commercial applications currently exist, most of the current nanofluids are at Technological Readiness Levels (TRL) 1 to 3. Most of the nanofluids research in COST countries has been conducted by Research, Development and Innovation (R+D+i) centres through national funding. Additional coordinated research and development efforts are required to develop nanofluids up to higher TRL levels and to overcome commercial application barriers. If these barriers are overcome, nanofluids will be an important player in the Value Added Materials (VAM) for the energy sector.The objective of the NANOUPTAKE COST Action is to create a Europe-wide network of leading R+D+i institutions, and of key industries, to develop and foster the use of nanofluids as advanced heat transfer/thermal storage materials to increase the efficiency of heat exchange and storage systems.
Project webpage:	http://www.cost.eu/COST_Actions/ca/CA15119
Duration:	19.4.2016 – 18.4.2020

CHINMEDAMY – Discovery and Mechanism of Small Molecule Compounds from Traditional Chinese Medicine for treatment of Alzheimer \’s Disease
Identifikácia a mechanizmus účinku malých molekúl využívaných v tradičnej čínskej medicíne na liečbu Alzheimerovej choroby
Program:	Bilateral – other
Project leader:	doc. RNDr. Gažová Zuzana, DrSc.
Duration:	1.1.2018 – 31.12.2019

Point-contact and tunneling spectroscopy of emergent iron-based superconductors
Mikrokontaktová spektroskopia supravodičov na báze železa
Program:	Inter-academic agreement
Project leader:	prof., RNDr. Samuely Peter, DrSc., akademik US Slovenska
Annotation:	Point-contact and low temperature scanning tunneling spectroscopy of the most prospective iron pnictide and chalcogenide superconductors is planned to obtain information about the typical boson excitations and anisotropy of the superconducting gap, multi-zone and interface effects to identify characteristics features of superconducting state in these compounds and a deeper understanding their nature.
Duration:	1.1.2017 – 31.12.2019

BIOSAP – Design of nanostructured bio-hybrid materials through self-assembly process
Nanoštrukturované bio-hybridné materiály generované samousporiadajúcimi procesmi
Program:	Bilateral – other
Project leader:	RNDr. Tomašovičová Natália, CSc.
Annotation:	The aim of the present project proposal is to significantly contribute to the better understanding of the complex interaction between magnetic nanoparticles and host matrix based on the lyotropic liquid crystal. One of the key tasks of the project herein is to prepare bio-inorganic hybrids based on liquid crystals formed by lysozyme fibrils alongside doping of magnetic nanoparticles, to study the interaction between magnetic nanoparticles and lysozyme amyloid fibrils as well as their consequential structure. The project proposal primarily targets experimental research on a phenomenon observed in biological anisotropic colloidal suspensions, which have been extensively studied for its consequential relation with many human neurodegenerative disorders such as Alzheimers disease, Hungtingtons disease, and etc. Self-assembly of colloidal nanomaterials makes it possible to obtain structures with high level of ordering and permit construction of patterns to be used in optoelectronics, photonics and biosensing. However, the exact principle of mechanisms and the nature of the phenomenon are still unknown, and represent unexplored areas of research. Various experimental techniques already available at the collaborating institutions as detailed below will be employed to attain the main objective of the project as well as the related objectives itemized in the proposal.
Duration:	1.1.2018 – 31.12.2019

Research on preparation and magnetic properties of Co/CoO core-shell nanoparticles
Príprava a magnetické vlastnosti Co/CoO core-shell nanočastíc
Program:	Inter-academic agreement
Project leader:	RNDr. Škorvánek Ivan, CSc.
Duration:	1.1.2018 – 31.12.2019

MMP REBCO – RE211 nanosize pining centers in REBCO bulks formed by modified precursor powder process
RE211 nanorozmerové piningové centrá v REBCO masívnych supravodičoch vytvorené MPP procesom
Program:	Bilateral – other
Project leader:	Ing. Diko Pavel, DrSc., akademik US Slovenska
Annotation:	REBa2Cu3O7 (in short REBCO or RE123, RE = Y or rare earth) bulk singlegrain superconductors (BSS) are a new unique class of superconductors with a perspective of being superconducting permanent magnets. One way to get closer to their practical applications is to reduce the price or to increase their properties by applying more efficient progressivetechnological procedures for their fabrication. The refinement of pining centers in the form of non-superconducting particles of the RE2BaCuO5 (RE211) phase is an important task in the production of REBCO BSS by top-seeded melt-growth (TSMG) process in the form of highparameter cryomagnets. The Laboratory of Materials Physics (LMF) at IEP SAS and the Department of Physics of JTU Shanghai have long been involved in the REBCO BSS research and have achieved a significant international position in this area. The latest results of collaborative groups show that replacing the conventional Y211 powder addition into the nominal composition by the mixture of Y2O3 and Ba2Cu3x powders can create nanoscale Y211 pining centers which will lead to a significant increase in the value of the maximum trappped magnetic field. Within the joint project, we want to extend this efficient process to SmBCO and GdBCO type BSS, which generally show higher values of the trapped magnetic field than YBCO BSS. In fulfilling this goal, we will seek optimal chemical composition and growth conditions of bulk crystals. Growth of BSS will take place mainly at the Departments of Physics, Shanghai Jiao Tong University during the stay of young scientists from LMF. The microstructural analysis and characterization of superconducting properties will be performed mainly at LMF. The planned mutual cooperation will significantly contribute to a faster progression of REBCO MMS research, in particular by complementing collaborative knowledge, joint use of unique experimental methodologies at individual labs as well as the scientific advancement of young scientists
Duration:	1.1.2018 – 31.12.2019

Superconductivity of boride thin films
Supravodivosť tenkých filmov boridov
Program:	Bilateral – other
Project leader:	doc. RNDr. Flachbart Karol, DrSc., akademik US Slovenska
Annotation:	The aim of the proposed project is to prepare thin films of superconducting high-boron borides(YB6, ZrB12 and LuB12) and investigate their superconducting properties as function ofthickness, microstructure and of applied pressure. The outcome of this investigation will be newknowledge about how superconducting properties of bulk (3D) boride superconductors changewhen they become (quasi) two dimensional (2D). As a result, a variation of superconductingproperties is expected above all due the change of rich boride phonon spectra (and the relatedelectron-phonon interaction) when the structure changes from a 3D one to a 2D one.
Duration:	1.1.2018 – 31.12.2019

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Synthesis and comparison of properties of Fe3O4 and (La,Sr)MnO3 nanoparticles and magnetic fluids based on them
Program:	Inter-institute agreement
Project leader:	RNDr. Timko Milan, CSc.
Duration:	1.1.2018 – 31.12.2019

SOOSA – Study of orientation ordering and self-assembly in biopolymer and liquid crystal
Štúdium usporiadania, orientácie a samozbaľovania v biopolyméroch a kvapalných kryštáloch
Program:	Bilateral – other
Project leader:	RNDr., Ing. Šipošová Katarína, PhD.
Annotation:	Liquid crystals (LCs) are matter in a state which has properties between those of conventional liquids and those of solid crystals. Examples of liquid crystals can be found both in the natural world and in technological applications. LCs actually exhibit a plethora of unique and attractive properties that offer tremendous potential for fundamental science as well as innovative applications depending on ordering properties of anisotropic molecules at interfaces in systems. In particular, new bio-nanocomposites consisting of protein amyloid fibrils (that can be consider as long and rigid objects similarly copolymers due to their stability and rigidity) and magnetic nanoparticles provide achievement of high special order and alignment. Within the project, we propose to focus on the effects of backbone-alignment on the ordering and self-assembly in these systems.
Duration:	1.1.2018 – 31.12.2019

Theoretical and experimental studies of orientational, magneto-optical and dielectric properties of composite liquid crystals filled with magnetic particles.
Teoretické a experimentálne štúdium orientačných, magneto-optických a dielektrických vlastností kompozitov kvapalných kryštálov dopovaných magneticckými časticami.
Program:	Inter-academic agreement
Project leader:	RNDr. Tomašovičová Natália, CSc.
Annotation:	At the last decades, one of the important areas of modern soft matter physics is theoretical and experimental study of liquid crystals (LC) which are very attractive for use in various commercial exploitations. The great interest of researchers to this area of science is explained, first of all, by fast development of electronic technique and communication equipments which require reliable, convenient and compact devices for processing and displaying information – indicators, displays, screens, etc. The successful use of LC materials in such devices considerably expanded a circle of technical applications of liquid crystals: now they are applied also in modern industrial machineries, in different transport vehicles and systems, medicine, household appliances, etc. Additionally, the search for new materials with exotic properties and for new technologies continues, in order to comply with the needs of these, and other novel applications.
Duration:	1.1.2017 – 31.12.2019

National

Frustrated metallic magnetic systems
Frustrované kovové magnetické systémy
Program:	DoktoGranty
Project leader:	Ing. Bačkai Július
Duration:	1.1.2023 – 31.12.2023

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Funkcionalizované magnetické nanočastice pre MRI zobrazovanie distribúcie liečiva v pľúcach pri akútnom syndróme respiračnej tiesne (ARDS)
Program:	DoktoGranty
Project leader:	Mgr. Sobotová Radka
Duration:	1.1.2023 – 31.12.2023

Characterizations of Shape Memory Microwires for Micro Actuator and Micro Sensor
Characterizations of Shape Memory Microwires for Micro Actuator and Micro Sensor
Program:	DoktoGranty
Project leader:	MSc Nulandaya Limpat
Duration:	1.1.2023 – 31.12.2023

Magnetic frustration and superconductivity in 2D and 3D borides
Magnetická frustrácia a supravodivosť v 2D a 3D boridoch
Program:	VEGA
Project leader:	RNDr. Pristáš Gabriel, PhD.
Annotation:	Borides form a wide class of materials with different physical properties. Metallic geometrically frustratedmagnetic tetraborides (REB4) are 2D frustrated systems and together with their fcc 3D counterpartsdodecaborides (REB12) pose an ideal playground for study of 2D/3D interplay of frustration in megnetic systems.Uniaxial pressure, as well as hydrostatic pressure will be the tuning parameters which can change the interactionbetween magnetic moments. Depending on the direction of uniaxial pressure we will be able to change themagnitude of interactions in different crystallographic directions and test theoretical predictions. A similarcrossover between 2D and 3D can be studied also in superconducting borides as YB6, ZrB12 and LuB12. Even ifthere exist at present time a rather good understanding of the physical properties of bulk metallic borides, thereare still serious open questions what will happen if one dimension will be reduced considerably – by preparingthin films of corresponding borides.
Duration:	1.1.2020 – 31.12.2023

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Magnetizačné procesy kompozitov s magnetickými časticami s modifikovaným povrchom
Program:	VEGA
Project leader:	RNDr. Kováč Jozef, CSc.
Duration:	1.1.2020 – 31.12.2023

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Malá projektová schéma
Program:	Other projects
Project leader:	Ing. Molčan Matúš, PhD.
Duration:	1.1.2023 – 31.12.2023

New Insight into the Role of Hydrophobic Interactions in Formation and Stability of Proteins Aggregates. Link to Oxidative Stress.
Nový pohľad na vplyv hydrofóbnych interakcií na tvorbu a stabilitu proteínových agregátov. Prepojenie na oxidačný stres.
Program:	VEGA
Project leader:	MUDr. Musatov Andrey, DrSc.
Duration:	1.1.2021 – 31.12.2023

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Štruktúra a dynamika magnetických kvapalín v elektrickom poli
Program:	VEGA
Project leader:	RNDr. Rajňák Michal, PhD.
Annotation:	Magnetic fluids (MF) are suspensions of magnetic nanoparticles (MNP) in a liquid carrier. Their behavior inmagnetic field is intuitive and scientifically well explored. Within the fundamental research on MF, electricalproperties of MF are actively studied, the clear understanding of which requires deeper experimental study. Themechanism of electrical breakdown and structural changes of MF in external electric field belong to the mostintriguing properties of MF. The objective of this project is to investigate these phenomena experimentally in MFbased on nonpolar liquids. Within the project, the streamer development will be visualized and investigated. Theanalysis will take into account the model of electric charge trapping on MNP. Dielectric spectroscopy,neutronography and microscopy of MF in electric field will be employed. The other objective is to prove ordisprove a hypothesis of electromagnetic coupling between the spontaneous magnetic moment and inducedelectrical polarization of MNP.
Duration:	1.1.2020 – 31.12.2023

Research of non-trivial superconductivity on selected materials.
Štúdium netriviálnej supravodivosti vybraných materiálov.
Program:	VEGA
Project leader:	RNDr. Kačmarčík Jozef, PhD.
Duration:	1.1.2020 – 31.12.2023

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Teoretické štúdium multifunkčných kvantových nízko-rozmerných magnetických materiálov
Program:	VEGA
Project leader:	RNDr. Vargová Hana, PhD.
Annotation:	Multifunctional magnetic materials represent an ideal platform for nowadays technological demands. Reduceddimensions drag out their quantum properties opening thus new paradigms for possible utilization. The projectaims to study exotic quantum states in low-dimensional magnetic materials. We plan to utilize first principlescalculations based on density functional theory with the aim to propose and solve realistic effective quantum spinmodels for representative systems, which exhibit an enhanced magnetoelectric and/or barocaloric response in a vicinity of classical or quantum phase transitions. The present proposal focuses on frustrated quantumHeisenberg spin systems with flat bands appearing due to a destructive quantum interference, magnon-crystalphases (Wigner crystal of magnons) relevant for technological applications and one-dimensional quantum spin chains suitable for quantum information processing.
Duration:	1.1.2020 – 31.12.2023

ECODISC – Electron correlations in disordered superconductors
Elektrónové korelácie v neusporiadaných supravodičoch
Program:	SRDA
Project leader:	Mgr. Szabó Pavol, CSc.
Annotation:	Project aims at understanding of the effect of disorder on superconductivity in systems which are close to Superconductor-Insulator Transition as well as in thin films of hydrides. The thin films of MoN, MoC, TiN of various thickness and stoichiometry and on different substrates as well as polycrystalline and nanostructured boron-doped diamond will be prepared. Some of these systems reveal fermionic and some bosonic effects insuperconducting state. By means of conductance measurements from DC to optical frequency range as well as by means of the scanning tunneling microscopy and spectroscopy at very low temperatures and in high magnetic field we will address the question of what kind of superconductivity is established in strongly disorderd systems where already quasiparticles out of superconducting state reveal renormalized density of states around the Fermi energy. We want also to understand the appearence of superconductivity in thin films of hydrides. We will explore the effect of disorder changing upon hydrogen content, thickness of film, substrate, microstructure and applied pressure on superconductivity in YHx, TiHx, VHx hydrides and their oxyhydrides.
Duration:	1.7.2019 – 30.6.2023

MIKROKELVIN – Quantum matters at very low temperatures – MICROKELVIN
Kvantové materiály pri ultra-nízkych teplotách – MIKROKELVIN
Program:	Štrukturálne fondy EÚ Výskum a inovácie
Project leader:	RNDr. Skyba Peter, DrSc.
Duration:	1.1.2020 – 30.6.2023

NANOVIR – –
Nanočastice pre riešenie diagnosticko-terapeutických problémov s COVID-19 (NANOVIR)
Program:	Štrukturálne fondy EÚ Výskum a inovácie
Project leader:	Ing. Závišová Vlasta, PhD.
Project webpage:	https://websrv.saske.sk/uef/veda-a-vyskum/projekty-v-ramci-opvai/nanovir/
Duration:	3.3.2021 – 30.6.2023

NANOELEN – Nanofluids in Electrical Engineering
Nanokvapaliny v elektrotechnike
Program:	SRDA
Project leader:	RNDr. Rajňák Michal, PhD.
Annotation:	The submitted project is oriented on research into nanofluids based on alternative cooling and insulating liquidmedia such as oils based on liquefied natural gas, natural esters and new types of transformer oils. We willprepare novel nanofluids based on these oils by dispersing magnetic nanoparticles, fullerenes, graphenenanoplatelets or carbon nanotubes. The purpose of the nanofluids preparation is to enhance the coolingeffectiveness of the liquid media. The nanofluids will be investigated from dielectric, insulating, magnetic andheat transfer properties point of view. Finally, their cooling effectiveness will be tested in loaded powertransformers. Therefore, the aim of this project is the development of advanced liquid media for cooling andinsulating in electrical engineering, the application of which will have a potential impact on electric power saving,electrical equipment service life and protection of the environment.
Duration:	1.7.2019 – 30.6.2023

BIOVID-19 – –
Vývoj biomodelov pre zlepšenie hodnotenia účinnosti liekov a látok, ktoré majú potenciál pri liečbe COVID-19 (BIOVID-19)
Program:	Štrukturálne fondy EÚ Výskum a inovácie
Project leader:	Ing. Koneracká Martina, CSc.
Project webpage:	https://websrv.saske.sk/uef/veda-a-vyskum/projekty-v-ramci-opvai/biovid-19/
Duration:	29.6.2021 – 30.6.2023

MULTIHIT – Multi-target inhibitors of poly/peptides associated with Alzheimer´s disease
Multifunkčné inhibítory poly/peptidov spojených s Alzheimerovou chorobou
Program:	SRDA
Project leader:	doc. RNDr. Gažová Zuzana, DrSc.
Duration:	1.7.2019 – 1.6.2023

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Aplikácia matematickej fyziky v rôzne škálovateľných systémoch
Program:	VEGA
Project leader:	RNDr. Pinčák Richard, PhD.
Duration:	1.1.2019 – 31.12.2022

DIAGNAD – –
DIAGNAD
Program:	Štrukturálne fondy EÚ Výskum a inovácie
Project leader:	doc. RNDr. Gažová Zuzana, DrSc.
Annotation:	The project will carry out independent research and development of new diagnostic substances for Alzheimer\’s disease based on high-affinity natural substances labeled with radioisotopes or nanoparticles. The goal is also to expand knowledge in the underdeveloped field of Alzheimer\’s disease (ACH) diagnostics and to better understand the mechanisms leading to the formation and development of this progressive and incurable disease.
Duration:	1.1.2021 – 31.12.2022

FRUSTKOM – Frustrated metallic magnetic systems
Frustrované kovové magnetické systémy
Program:	SRDA
Project leader:	doc. RNDr. Gabáni Slavomír, PhD.
Annotation:	The up to now experimental and theoretical studies of frustrated magnetic systems (FMS) has been concentrated mainly on dielectric systems. Such systems can be found in 2D and 3D lattices based on equilateral triangles, and in dielectrics the interaction between their spins can be relatively well defined and described. In metallic FMS (M-FMS), which have been much less studied, an important role plays the long-range indirect exchange interaction between the spins mediated by conduction electrons (the RKKY interaction). To the small number of up to now studied M-FMS belong also some rare earth metallic borides having a fcc (e.g.HoB12, ErB12) or Shastry-Sutherland (e.g.TmB4, HoB4, ErB4) structure. This project aims are to investigate experimentally the impact of high pressure (hydrostatic and uniaxial), the influence of alloying and the anisotropy on the magnetic, transport and thermal properties of M -FMS, which has not been studied yet. A pioneering work will be above all the direct observation of magnetic structures of individual phase diagram regions of these M-FMS by spin-polarized scanning tunnelling microscopy. Investigated will be also the dynamics of magnetic structures (the influence of the rate of change of the magnetic field on these structures) and the study of magnetic excitations (by neutron diffraction methods) in selected tetraborides and dodecaborides.The challenging experimental studies, for which both high quality samples and suitable methods are already available, will be supported by the theoretical interpretation of received results, and by the theoretical elaboration.
Project webpage:	http://extremeconditions.saske.sk/projects/
Duration:	1.8.2018 – 31.12.2022

Functionalization of magnetic nanoparticles for cancer cell detection
Funkcionalizácia magnetických nanočastíc na detekciu rakovinových buniek
Program:	VEGA
Project leader:	Ing. Koneracká Martina, CSc.
Annotation:	The presented project is focused on the preparation of a magnetic biocomplex that specifically detects cancer cells; it penetrates into their structure and enables better visualization of the affected areas, using magneticresonance imaging (MRI), for example. The surface of synthetized magnetic nanoparticles will be functionalized bydifferent amino acids. Several physicochemical methods (spectroscopic, microscopic, calorimetric, magnetic andothers) will be used to optimize the nanoparticle functionalization. We will also study the suitability of usingmodified nanoparticles for MRI. The next step will be the conjugation of a specific antibody to the functionalizednanoparticles (biocomplex) and the study of cell interaction with biocomplex by immunochemical methods.Considering the application purposes of magnetic nanoparticles, one of our goals will be investigation the effect ofprepared magnetic biocomplexes on cell viability in combination with magnetic hyperthermia.
Duration:	1.1.2019 – 31.12.2022

Ising superconductors and topologigal phases of the matter
Isingove supravodiče a topologické fázy hmoty
Program:	VEGA
Project leader:	Mgr. Szabó Pavol, CSc.
Duration:	1.1.2019 – 31.12.2022

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Kozmické žiarenie v heliosfére s terminačnou rázovou vlnou a heliosférickou obálkou
Program:	VEGA
Project leader:	RNDr. Bobík Pavol, PhD.
Duration:	1.1.2020 – 31.12.2022

MODEX – –
MODEX
Program:	Štrukturálne fondy EÚ Výskum a inovácie
Project leader:	doc. RNDr. Kopčanský Peter, CSc.
Duration:	1.1.2021 – 31.12.2022

Rapidly quenched metallic alloys and composites for magnetic and magnetocaloric applications
Rýchlochladené kovové zliatiny a kompozity pre magnetické a magnetokalorické aplikácie
Program:	VEGA
Project leader:	RNDr. Škorvánek Ivan, CSc.
Annotation:	The project addresses the development of novel rapidly quenched alloys with improved functional properties. Its first part will be focused on soft magnetic nanocrystalline alloys with high values of saturation magnetic inductions, which is possible to obtain by lowering of the content of non-magnetic elements in alloy and by utilization of the ultra-rapid annealing technique during the crystallization process. The other part of this project will be devoted to amorphous and nanocrystalline composites in the form of bilayer or trilayer ribbons, with the solid mechanical interface between them. In these heterogeneous systems, we will perform a detailed study of their magnetic properties. In addition, we plan also to optimize their GMI characteristics for potential magnetic sensor applications. In the project, we will focus our attention also on development of rapidly quenched composites with optimized magnetocaloric properties for magnetic cooling in the vicinity of room temperature.
Duration:	1.1.2019 – 31.12.2022

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Samousporiadanie polymérnych a nepolymérnych materiálov v kvapalnom stave na mezoškálach
Program:	VEGA
Project leader:	RNDr. Sedlák Marián, DrSc.
Duration:	1.1.2020 – 31.12.2022

Tear fluid and saliva in preventive, predictive and personalized medicine
Slzná tekutina a sliny v preventívnej, prediktívnej a personalizovanej medicíne
Program:	VEGA
Project leader:	RNDr. Tomašovičová Natália, CSc.
Annotation:	Tear fluid and saliva are non-traditional biological collected material. Collection is non-invasive, which is anadvantage compared to blood collection as a standard biological material. It is not colored, contains water andelectrolytes, proteins, lipids, hormones and others. Characterization of its composition in various inflammatorydiseases with a focus on amyloid formation by using several methods represents an approach of preventive,predictive and personalized medicine. Body fluid content in patients with pathological conditions variessignificantly compared to healthy subjects. There are still unexplained interindividual changes in non-traditionalbody fluids in clinical-diagnostic practice, but these differences may allow personal diagnosis and application oftailor-made treatments.
Duration:	1.1.2020 – 31.12.2022

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Štúdium pôsobenia hybridných molekúl na amyloidnú agregáciu globulárnych a prirodzene rozbalených proteínov
Program:	DoktoGranty
Project leader:	RNDr. Borovská Barbora
Duration:	1.1.2022 – 31.12.2022

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Štúdium termodynamických vlastností frustrovaných magnetických systémov exaktne riešiteľnými modelmi
Program:	VEGA
Project leader:	RNDr. Jurčišinová Eva, PhD.
Annotation:	The main aim of the project will be the study of various thermodynamic properties of antiferromagnetic as well as ferromagnetic frustrated systems in the framework of exactly solvable classical models of the statistical mechanics. In the framework of the realization of the project the main attention will be concentrated on the investigation of their properties related to the frustration such as anomalous low-temperature behavior of the specific heat capacity; magnetocaloric effect and the corresponding (de)magnetization adiabatic cooling processes and their effectiveness; magnetization properties, structure and macroscopic degeneracy of ground states; entropic properties and critical behavior of frustrated systems, as well as the influence of various additional interactions on these properties and processes.
Duration:	1.1.2019 – 31.12.2022

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Určenie parametra fázovej tuhosti v supravodičoch
Program:	DoktoGranty
Project leader:	Ing., Bc. Kuzmiak Marek
Duration:	1.1.2022 – 31.12.2022

Impact of magnetic and electric field on structure of magnetic fluids
Vplyv magnetického a elektrického poľa na štruktúru magnetických kvapalín
Program:	DoktoGranty
Project leader:	Mgr. Karpets Maksym
Duration:	1.1.2021 – 31.12.2022

BMREBCO – Development of REBCO superconductors for biomedical applications
Vývoj REBCO supravodičov pre biomedicínske aplikácie
Program:	SRDA
Project leader:	Ing. Diko Pavel, DrSc., akademik US Slovenska
Annotation:	The project focuses on the development of REBCO bulk singlegrain superconductors (BSS) for biomedical applications. Their use is envisaged by the small enterprise CRYOSOFT s.r.o. Košice for design of equipments for the magnetic separation of cells and for the magnetic transport of drugs. For these applications, REBCO BSS will be developed for use at temperatures that can be achieved by cryocooling (30-50K). We will study YBCO, SmBCO and GdBCO systems that can meet the requirements for the expected applications. The raw material price for YBCO BSS is lower than for SmBCO and GdBCO BSS, however, the SmBCO and GdBCO are reaching higher values of trapped magnetic field. Within the project solution, the optimized composition and the preparation technology of REBCO BSS will be found in order to achieve efficient pining in high magnetic fields below temperature of liquid nitrogen, which is a prerequisite for achieving high critical current density and high trapped magnetic field. The critical current density will be improved through chemical pining, refining RE211 particles, adding nanofibers. We will take advantage of our previous results in basic and applied research of REBCO BSS, some of which are patent-protected.
Project webpage:	https://websrv.saske.sk/uef/oddelenia-a-laboratoria/laboratorium-materialovej-fyziky/
Duration:	1.8.2018 – 30.6.2022

LEAPSynPD – Inhibition of α-Synuclein Aggregation by LEA Proteins: A New Approach for Parkinson’s Disease Treatment
Inhibícia agregácie α-synukleínu pomocou LEA proteínov: nový prístup pre liečbu Parkinsonovej choroby
Program:	SRDA
Project leader:	doc. RNDr. Gažová Zuzana, DrSc.
Annotation:	Intracellular protein aggregates mostly composed of α-Synuclein (α-Syn) are a pathological hallmark of Parkinson’s disease (PD), one of the world’s fastest growing neurological disorders. Recently, no efficient cure is available, therefore the exploration of novel approaches towards the development of a radically new therapy is urgently required. The potential of LEA proteins to inhibit α-Syn aggregation will be studied with aim to structurally characterized the interactions of LEA proteins with α-Syn and provide top LEAP candidates with significant anti-aggregation potential.
Duration:	1.1.2022 – 31.1.2022

Deformation of metastable amorphous and crystalline materials
Deformácia metastabilných amorfných a kryštalických materiálov
Program:	VEGA
Project leader:	RNDr. Csach Kornel, CSc.
Duration:	1.1.2018 – 31.12.2021

Detection of space plasma and energetic particles on board of space probes.
Detekcia kozmickej plazmy a energetických častíc na palube vesmírnych sond.
Program:	VEGA
Project leader:	Ing. Baláž Ján, PhD.,
Annotation:	The project is oriented to investigation of particle environment of Earth\’s magnetosphere, interplanetary environment and in magnetospheres of other planets of Solar system, particularlyat the field of design and development of space experimental devices. The Department of Space Physics has long history in this topic and has a reach international cooperation with similar workplaces of space research. The project requires procurement of electronic components, mechanical works, travel expenses for meetings, testing and launch campaigns.The current project space activities:- development of charged particle detector ASPECT-L for mission LUNA-Resurs- development of charged particle detector DOK-M for mission Resonance- development of net of UV photometers for airglow study- development of anti-coincidence module ACM for PEP/JDC science suite of the ESA JUICE mission to Jupiter
Duration:	1.1.2019 – 31.12.2021

Classical to quantum crossover in mechanical resonators
Klasicko-kvantový prechod v mechanických rezonátoroch
Program:	VEGA
Project leader:	RNDr. Človečko Marcel, PhD.
Annotation:	The material variability and dimensional diversity of mechanical resonators allows us to deliberately change their physical and geometric properties. Thus by reducing their mass / energy content (i.e. by decreasing their size)while simultaneously cooling them to temperatures close to absolute zero, it is possible to use them as a tool tostudy the crossover between classical and quantum dynamics. The ambition of our project is (i) the study of nonlinear processes in macroscopic resonators based on piezomaterials, (ii) the study of the transition between classical and quantum dynamics by using our custom made mechanical micro and nanoresonators and (iii) to deepen the understanding of fundamental processes of the energy exchange between these resonators and thethermal reservoir leading to the decoherence.
Duration:	1.1.2018 – 31.12.2021

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Kozmické energetické častice zo slnečných erupcií – mnohobodové pozorovanie od Slnka až po Lomnický Štít
Program:	VEGA
Project leader:	RNDr. Mackovjak Šimon , PhD.
Duration:	1.1.2018 – 31.12.2021

ARES – Alloyed REBCO bulk superconductors
Legované REBCO masívne supravodiče
Program:	VEGA
Project leader:	Ing. Diko Pavel, DrSc., akademik US Slovenska
Annotation:	The project is focuses on the research of the influence of alloying (doping) on the structure and superconducting properties of REBCO bulk single-grain superconductors. The effect of alloying on the phase equilibrium, the growth of bulk crystals, the formation of pining centers, magnetic flux picking mechanisms, local and macroscopic superconducting properties in the temperature range achievable by cryocoolers will be investigated. Experimental methods of powder metallurgy, growth of bulk single-crystals, X-ray diffraction, microscopic optical and electron microstructure analysis and electron microanalysis, magnetization measurements and measurement of trapped magnetic field  will be used. The project will be developed in cooperation with the leading foreign laboratories  within the framework of formal  (SIT Tokyo, JTU Shanghai, CAN Superconductors Prague) and the informal(University of Cambridge, KAERI Daegeon, CRISTMAT Caen, FZÚ Prague) cooperation.
Duration:	1.1.2019 – 31.12.2021

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Mióny ako nástroj na skúmanie jaskynných systémov
Program:	VEGA
Project leader:	RNDr. Putiš Marián, PhD.
Duration:	1.1.2021 – 31.12.2021

Supramolecular complexes of proteins – conformational transitions, stability and aggregation
Nadmolekulárne komplexy proteínov – konformačné prechody, stabilita a agregácia
Program:	VEGA
Project leader:	RNDr. Fedunová Diana, PhD.
Annotation:	Protein aggregation and self-assembly into supramolecular complexes occurs in various biological processes. Fibrillar aggregates – amyloids are hallmark of various diseases. Amyloid fibrils are part of physiological processes in cells and are also tested as novel biomaterials. The project is focused on study of the effect of two classes of cosolvents on amyloid aggregation of structurally different polypeptides – globular lysozyme and intrinsically disordered Aß peptide. The aim of the project is to find the relation between cosolvent properties and their effect on conformation, stability and kinetics of amyloid aggregation and morphology of obtained fibrils.Elucidation of these relations is important for the understanding of the mechanism of amyloid aggregation and can help to design new therapeutics against amyloid-related diseases, for identification of pathological structuralmotifs of fibrils as well as in biotechnological application of fibrils as novel materials.
Duration:	1.1.2018 – 31.12.2021

Novel statistical and correlation methods in analysis of parametric models of surfaces and their distributions.
Nové metódy v štatistickej a korelačnej analýze parametrických modelov povrchov a ich distribúcií
Program:	VEGA
Project leader:	RNDr. Marek Jozef, PhD.
Duration:	1.1.2019 – 31.12.2021

Orthorhombic multiferroic materials with strong magneto – electric coupling: effect of substitution in octahedral sites on magnetism and multiferroicity
Ortorombické multiferoické materiály so silnou magneto – elektrickou väzbou: vplyv substitúcie v oktaedrických polohách na magnetizmus a multiferoicitu
Program:	VEGA
Project leader:	RNDr. Mihalik Marián, CSc.
Annotation:	Single crystals of RMnxT1-xO3 (R = Nd, Pr, Sm, Tb, Dy and T = Ti, Mn, Fe) will be grown by optical floating zone method. We will study the evolution of the Jahn-Teller distortion of crystal lattice and orbital ordering with substitution of Mn3+with non-active Jahn-Teller ion. We will focus to the construction of magnetic phase diagrams with particular emphasis on determination of magnetic structure by means of magnetization, heat capacity, neutron diffraction measurements and study of critical coefficients. A part of the project is devoted to study of functional nanoparticles. We will pay special attention to tuning of magneto-electric coupling in multiferroic compounds (RMnO3, R = Tb, Dy or RFeO3, R = Gd, Dy) with magnetically induced ferroelectricity by low concentration doping with Ti, Cr and Fe or Mn respectively. Recent study of these systems supposed new physical hypothesis referring the duality of multiferroicity and we hope that our project will contribute to verification of this hypothesis.
Duration:	1.1.2019 – 31.12.2021

Investigation of nuclear matter properties in heavy quark production on nuclear targets
Skúmanie vlastností jadrovej matérie v produkcii ťažkých kvarkov na jadrových terčíkoch
Program:	VEGA
Project leader:	doc. RNDr. Nemčík Ján, CSc.
Annotation:	The main goal of the present project is theoretical study of nuclear effects in various processes on nuclear targets at large energies. The main emphasize is devoted to production of heavy quarks representing an alternative probe for investigation of manifestations and properties of nuclear matter created in heavy-ion collisions.
Duration:	1.1.2018 – 31.12.2021

Systematic study of influence of local and nonlcal interactions on coexistence of quantum phases with different order parameters
Systematické štúdium vplyvu lokálnych a nelokálnych interakcií na koexistenciu kvantových fáz s rôznymi parametrami usporiadania
Program:	VEGA
Project leader:	RNDr. Farkašovský Pavol, DrSc.
Annotation:	The proposed project is focused on the complex study of influence of local and non-local interactions, of the Coulomb and spin nature, on the ground state properties of the generalized two-band Hubbard model. The results obtained will be used for a description of anomalous cooperative phenomena in real materials with strongly correlated electrons. The study will include a wide class of cooperative phenomena such as valence and metal-insulator transitions, charge and spin ordering, itinerant ferromagnetism, electronic ferroelectricity, supercoductivity, excitonic matter and will concern a wide class of materials such as nickelates, cobaltates, rare-earth hexaborides and chalcogenides,multiferroics, etc. The emphasis will be put on the study of influence of combined effects of two or more interactions with a goal to describe coexistence of two or more quantum phases with different order parameters (ferromagnetic-ferroelectric state, charge/spin ordering-superconductivity, etc.).
Duration:	1.1.2018 – 31.12.2021

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Štúdium anti-oxidačnej a zosilnenej anti-amyloidnej aktivity nanočastíc céru pre biomedicínske aplikácie
Program:	DoktoGranty
Project leader:	RNDr. Garčárová Ivana
Duration:	1.1.2021 – 31.12.2021

Influence of chemical composition on unique physical properties of modern functional materials
Vplyv chemického zloženia na význačné fyzikálne vlastnosti moderných funkčných materiálov.
Program:	VEGA
Project leader:	RNDr. Kováč Jozef, CSc.
Annotation:	The project is focused on study of the influence of chemical composition on unique physical properties ofamorphous and Heusler- based alloys. Mainly, the influence of chemical composition on basic parameters thatinfluence magnetic bistability of amorphous microwires will be studied, which can be employed in construction ofminiaturized contactless sensors of magnetic field, temperature and mechanical stress. On the other hand,Heusler -based microwires will be studied that are characterized magnetocaloric effect and shape memory effect.They can be employed in construction of smart actuators that also serves as sensors. The main focus isdevelopment of materials with such composition that exhibit above-mentioned effect, but can be producedrepeatedly on a large scale.
Duration:	1.1.2019 – 31.12.2021

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Vplyv veľkosti nanočastíc na ac susceptibilitu feronematík
Program:	DoktoGranty
Project leader:	RNDr. Kónyová Katarína, PhD.
Duration:	1.1.2020 – 31.12.2021

EXSES – Exotic quantum states of low-dimensional spin and electron systems
Exotické kvantové stavy nízkorozmerných spinových a elektrónových systémov
Program:	SRDA
Project leader:	RNDr. Vargová Hana, PhD.
Annotation:	The project is devoted to theoretical study of low-dimensional quantum spin and electron systems, which will beexamined by the combination of advanced analytical and numerical methods including among other mattersexact mapping transformations, transfer-matrix method, strong-coupling approach, classical and quantum MonteCarlo simulations, exact diagonalization and density-matrix renormalization group method. The obtainedtheoretical outcomes will contribute to a deeper understanding of exotic quantum states of spin and electronsystems such as being for instance different kinds of quantum spin liquids as well as quantum states with asubtle long-range order of topological character or with a character of valence-bond solid. The project willsignificantly contribute to a clarification of unconventional magnetic behavior of selected low-dimensionalmagnetic materials and thus, it will have significant impact on a current state-of-the-art in the field of condensedmatter physics and material science. On the other hand, a detailed investigation of quantum entanglement willestablish borders of applicability of the studied spin and electron systems for the sake of quantum computationand quantum information processing. Another important outcome of the project is to clarify nontrivial symmetriesin tensor states of the strongly correlated spin and electron systems affected by either position dependentinteractions or changes in lattice geometries, which induce phase transitions of many types.
Duration:	1.7.2017 – 30.6.2021

Interactions of relativistic nuclei, eta-meson nuclei and spin physics
Interakcie relativistických jadier; eta-mezónové jadrá a spinová fyzika
Program:	VEGA
Project leader:	Mgr. Mušinský Ján, PhD.
Duration:	1.1.2018 – 31.12.2020

QuTeMaD – Quantum Technologies, Materials and Devices
Kvantové technológie. materiály a zariadenia
Program:	SRDA
Project leader:	prof., RNDr. Samuely Peter, DrSc., akademik US Slovenska
Annotation:	Within the project we will focus on development of particular devices based on superconductors orsuperconducting circuits working up to quantum limit. One of the main goal of the project is a practical amplifierwhich bring real and considerable improvement over the high electron mobility transistor (HEMT) amplifiers. Ouraim is to go beyond the state-of-the-art and fabricate subquantum-limited parametric amplifier, a key element forquantum information processing with microwaves. In order to achieve this aim we will investigate novel quantummaterials which can improve properties of quantum devices. Therefore, the fundamental research of newtopological materials including topological insulators and superconductors will thus be a logical and integral partof our project.
Duration:	1.7.2017 – 31.12.2020

Macroscopic anisotropic composites based on liquid crystals and magnetic nanoparticles
Makroskopicky anizotrópne kompozity na báze kvapalnych kryštálov a magnetických nanočastíc
Program:	VEGA
Project leader:	RNDr. Tomašovičová Natália, CSc.
Annotation:	The proposal targets basic research on composite materials consisting of liquid crystals and various magnetic nanoparticles. Combination of the anisotropic properties of liquid crystals with the magnetic properties of the nanoparticles results in composites with unique magnetic and optical properties that the component materials themselves do not possess. The proposed studies concentrate on the increase of the sensitivity of our composite soft matter materials (liquid state) to magnetic fields and prepare new materials having unique dielectric, magnetic and optical properties. The main goal of the proposal is to influence the sensitivity of these anisotropicsystems to external magnetic field by adding suitable magnetic nanoparticles and by this way make a step forward towards potential applications in various magneto-optical or dielectric devices as for example sensors of low magnetic fields or light shutter.
Duration:	1.1.2017 – 31.12.2020

MODEX – –
Modifikované (nano)textilné materiály pre zdravotnícke technológie
Program:	Štrukturálne fondy EÚ Výskum a inovácie
Project leader:	doc. RNDr. Kopčanský Peter, CSc.
Duration:	1.1.2017 – 31.12.2020

MVISION – Nanoparticles in anisotropic systems
Nanočastice v anizotrópnych systémoch
Program:	SRDA
Project leader:	doc. RNDr. Kopčanský Peter, CSc.
Annotation:	The proposal is devoted to study complex anisotropic systems based on thermotropic as well as lyotropic(biological) liquid crystals. Liquid crystals represents the uniq state of matter, which is liquid but posses theanisotropic properties. The structuralization phenomena in such systems play key role in fundamental as well asin applied research. The main aim is to s influence the sensitivity of these anisotropic systems to externalmagnetic field, what will be done by adding suitable magnetic nanoparticles and open the way for theirapplications in magneto-optical devices.
Duration:	1.7.2016 – 31.12.2020

NANOSEG – Nanosegregation in soft matter of polymeric and nonpolymeric nature
Nanosegregácia v mäkkých látkach polymérneho a nepolymérneho charakteru
Program:	SRDA
Project leader:	RNDr. Sedlák Marián, DrSc.
Duration:	1.7.2017 – 31.12.2020

Functional and Structural Insights into the Phospholipid-Protein Interaction during Oxidative Stress
Oxidačný stres a fosfolipidovo-proteínové interakcie: funkčné a štrukturálne dôsledky
Program:	VEGA
Project leader:	MUDr. Musatov Andrey, DrSc.
Annotation:	Mitochondria play a critical role in cells metabolism and mitochondrial dysfunction has long been implicated in age-related neurodegenerative diseases. One currently accepted theory is that damage to mitochondria, the main source of reactive oxygen species (ROS), initiates these diseases. In fact, when ROS levels overpower the cell’s defenses (oxidative stress), proteins, nucleic acids and/or lipids are irreversibly damaged. Particularly important is that oxidative stress disrupts or modifies the protein-lipid interactions what is one of the essential features of normal cell operation. Such disruptions could be a decisive factor leading to ROS-induced diseases. To test this hypothesis and clearly elucidate the links between mitochondrial oxidative stress and cells dysfunction we propose to investigate both, (i) the role of phospholipid modification in ROS-induced damage to mitochondrial electron transport Complex IV, and (ii) the role of phospholipids and oxidatively modified phospholipids in amyloidogenesis.
Duration:	1.1.2017 – 31.12.2020

Self-assembly of poly/peptides into amyloid aggregates – mechanism, inhibition and cytotoxicity
Samousporiadanie poly/peptidov do amyloidných agregátov – mechanizmus, inhibícia a cytotoxicita
Program:	VEGA
Project leader:	doc. RNDr. Gažová Zuzana, DrSc.
Annotation:	Amyloid supramolecular complexes formed by poly/peptides are the most prevalent naturally occurring self-assembling systems. Formation of such complexes affects function of poly/peptides and is associated with more than 30 serious amyloid-related diseases such as Alzhemer’s disease or diabetes mellitus. The exactmechanism of amyloid self-assembly of poly/peptides is not known yet and no effective treatment of amyloidosis is established. The goal of the project is to study the mechanism of the amyloid aggregation of poly/petides with different native structures and identification of inhibitors of poly/peptide self-assembly since the inhibition of amyloid formation is one of the possible therapeutic approaches against amyloid-related diseases. We will focus on the determination of the correlation between the morphology of amyloid aggregates and their cytotoxicity as well as on the relationship between structure of the effective inhibitors and their anti-amyloid activity.
Duration:	1.1.2017 – 31.12.2020

Study of universal properties of diffusion proceses in turbulent environments
Štúdium univerzálnych vlastností difúznych procesov v turbulentných prostrediach
Program:	VEGA
Project leader:	RNDr. Jurčišin Marián, PhD.
Annotation:	One of the basic attributes of macroscopic physical, chemical, biological, and also social-economical and environmental systems is their stochasticity. This fact is the main reason for present intensive scientific interest about various stochastic systems. Advection of various admixtures in random environments, turbulence and magnetohydrodynamic turbulence, or crossing of cosmic particles through interstellar space, are typical examples. The importance of intensive Investigation of these problems is dictated by need for fundamental understanding of the physical nature of phenomena which are involved in them, as well as from the point of view of their potential future applications in technical praxis. The aim of the project is the study of the anomalous scaling of structure and correlation functions of fluctuating fields in turbulent systems without and with symmetry breaking, as well as the study and the calculation of universal characteristics of such turbulent systems.
Duration:	1.1.2017 – 31.12.2020

The role of surface states in samarium hexaboride and other valence-fluctuating systems exhibiting metal-insulator transition
Úloha povrchových stavov v hexaboride samária a iných zmiešanovalenčných systémoch vykazujúcich prechod kov-izolátor
Program:	VEGA
Project leader:	RNDr. Baťková Marianna, PhD.
Annotation:	Samarium hexaboride (SmB6) represents an important model system exhibiting metal-insulator transition. A mysterious property of this valence fluctuating semiconductor is that at lowest temperatures it does not reveal divergency of electrical resistivity, but behaves as a metal. SmB6 is nowadays intensively studied also as a possible topological insulator, while metallic topologically protected surface is considered to be a reason of absence of insulating ground state. However, the latest results provide evidence about trivial surface states in SmB6. The project aims to evaluate the role of surface states in electrical conduction of SmB6 by investigating SmB6 thin films, to evaluate relevance of the scenario of topological insulator and other alternative approaches to explain electrical conductivity in SmB6, thus to contribute to understanding the nature of electronic transport in SmB6 and similar systems.
Duration:	1.1.2017 – 31.12.2020

DIAGNAD – –
Výskum a vývoj látok pre diagnostiku Alzheimerovej choroby
Program:	Štrukturálne fondy EÚ Výskum a inovácie
Project leader:	doc. RNDr. Gažová Zuzana, DrSc.
Duration:	1.1.2017 – 31.12.2020

MICROMANIP – Image analysis of microscopic particles in the automation of optical manipulation techniques applicable in mikro/nanorobotics.
Obrazová analýza mikroskopických častíc pri automatizácii optických manipulačných techník aplikovateľných v mikro/nanorobotike.
Program:	SRDA
Project leader:	doc. Ing. Tomori Zoltán, CSc.
Annotation:	Mikromanipulation based on the laser optical traps represents a progressive method of basic research in the physical, chemical and biomedical sciences. An analogy between the optical manipulation and the robotics evokes exploitation of the artificial intelligence algorithms (computer vision, machine learning, planning of trajectories, etc.). According to some authors, the use of these methods in combination with physical models has led to the significant increase of the effectiveness compared to the classic optimization (up to 1000 times in SVM classifier trained in advance using the Lorenz-Mie scattering light model). The aim of the project is to use a similar philosophy for the experimental tasks solved in our laboratory – cells sorting and fusing, their physical properties measurement and etc. Using the apparatus for 2-photon polymerization we plan to manufacture microrobotic instruments controlled by the optical tweezers traps, e.g. a mikrorobotic arm (gripper). As continuity with our previous project, we would improve the interactive control of optical tweezers via NUI interface (using the position of the fingers and gaze, voice, gestures). This interface should be functional not only locally, but also remotely over a network connection.
Duration:	1.7.2016 – 30.6.2020

Analysis of EUSO-SPB, Mini-EUSO and ground UV detectors experiments measurement
Analýza meraní z experimentov EUSO-SPB, Mini-EUSO a siete pozemných UV detektorov
Program:	VEGA
Project leader:	RNDr. Bobík Pavol, PhD.
Annotation:	JEM-EUSO experiment is a project to determine the origin of ultra high energy particles. Its two most important precursor experiments are EUSO-SPB and Mini-EUSO ones. Both of them will yield new data during the years 2017 and 2018. This project is aimed to data processing from both experiments and from the grid of terrestrial detectors of UV radiation. EUSO-SPB is a flight of NASA SPB balloon with EUSO detector which will start in April 2017 from New Zealand fot at least 50 days long flight. Mini-EUSO detector is miniature version of JEM-EUSO detector, which will monitor UV background onboard International Space Station. Mini-EUSO flight and the beginning of its at least half year measurements will start at the end of the year 2017. Department of space physics IEP is building at the same time a grid of terrestrial detectors of UV background, which will start continuos measurements on minimallly 4 positions during the year 2017. Their operation is planned over the full duration of this project.
Duration:	1.1.2017 – 31.12.2019

ANGSTROM – Atomic structure and exceptional properties of intermetallics, amorphous, nanocrystalline and complex metallic alloys
Atomárna štruktúra a unikátne vlastnosti intermetalík, amorfných, nanokryštalických a komplexných kovových zliatin
Program:	SRDA
Project leader:	RNDr. Škorvánek Ivan, CSc.
Duration:	1.7.2016 – 31.12.2019

MACOMA – Design of the structure and the functional properties of soft magnetic 3-d transitions metals based composites
Dizajn štruktúry a funkčných vlastností magneticky mäkkých kompozitných materiálov na báze 3-d prechodných kovov
Program:	SRDA
Project leader:	RNDr. Baťková Marianna, PhD.
Annotation:	The project focuses on structure and functional properties design of 3-d transition metals based soft magneticcomposite materials, in which will be carried out the experimental research of functional properties of advancedmaterials with heterogeneous structure consisting of isolated ferromagnetic particles. Magnetic micro- and nanocompositesystems will be prepared using advanced powder metallurgy method and current chemical processes.The research will be focused on explanation of the interface influence on the electric, magnetic and mechanicalproperties investigated magnetic composite materials. Expected results extend the potential for application ofadvanced soft magnetic materials suitable for use in a medium frequencies, where ferrites are currently used.
Duration:	1.7.2016 – 31.12.2019

Interaction of magnetic fluids with electromagnetic field
Interakcia magnetických kvapalín s elektromagnetickým poľom
Program:	VEGA
Project leader:	RNDr. Timko Milan, CSc.
Annotation:	The proposed project will be devoted to the study magnetic principle of heating mechanism – hyperthermia in magnetic nanoparticles systems in dependence on preparation process, size and size distribution and magnetic properties. Besides usually used biocompatible spherical anoparticles as a subjects of this proposal will be special prepared magnetosome and magnetoferritin containing spherical magnetite nanoparticles. The obtainedexperiences for achievement high specific heat power will enable the application magnetic nanoparticles at cancer treatment in biomedicine.We aim to investigate the shielding (absorption and reflection) effects of transformer oil based magnetic fluid.Besides the unique cooling and isolating properties, these magnetic fluids can be reliable shielding medium in electromagnetic devices as well. The research on radiation stability of MFs will address electromagnetic fields and another type radiation.
Duration:	1.1.2016 – 31.12.2019

Complementary study of superconductivity of selected materials
Komplementárne štúdium supravodivosti vybraných materiálov
Program:	VEGA
Project leader:	RNDr. Kačmarčík Jozef, PhD.
Annotation:	Since the discovery of the two-gap superconductivity in MgB2 almost 15 years ago, a continuous search for other examples of this special feature is maintained. Another interesting issue of these days in condensed matter physics is investigation of materials with competing orders, where for example superconductivity coexists or compete with magnetic ordering or charge density waves. Within the project we will focus on study of several representatives of these groups – we will confirm or disconfirm presence of two energy gaps in LaRu4As12 and Bi2Pd, we will explore competing orders in CuxTiSe2 and CeCoIn5 and we will address spatially constrained superconductivity in granular doped diamond. Clarification of their superconducting mechanism could shed some light on other superconducting materials. We will also work on development of new experimental methods – implementation of a resistive calorimeter and mastering and further enhancement of local magnetometry using Scanning Hall-probe microscope.
Duration:	1.1.2016 – 31.12.2019

Magnetization and relaxation processes in magnetic particles and composites.
Magnetizačné a relaxačné procesy v magnetických časticiach a kompozitoch.
Program:	VEGA
Project leader:	RNDr. Kováč Jozef, CSc.
Annotation:	The project is oriented on experimental investigation of the structure and magnetic properties of magneticparticles with the size of several nanometers to several hundred micrometers. The particles (with amorphous,nanocrystalline, or polycrystalline structure) are based on ferromagnetic metals and alloys, and are covered withan inorganic or organic layer, and after technological treatments become precursors for the preparation ofcomposites. The research is focused on investigation the magnetization and relaxation processes inferromagnetic particles under different physical conditions as ferromagnetic phase content, temperature,amplitude and frequency of the magnetic field. Expected results will help to expand the application potential ofthis class of advanced materials for a variety of medical and technological applications.
Duration:	1.1.2016 – 31.12.2019

Magnetoelectric and magnetocaloric effect in exactly solvable lattice-statistical models
Magnetoelektrický a magnetokalorický jav v exaktne riešiteľných mriežkovo-štatistických modeloch
Program:	VEGA
Project leader:	RNDr. Vargová Hana, PhD.
Annotation:	Magnetoelectric and magnetocaloric effects will be examined in detail with the help of exactly solvablelattice-statistical models including Ising spin systems, Ising-Heisenberg spin systems and coupled spin-electronsystems, which consist of localized Ising spins and delocalized electrons. The primary goal of the project is toexplore an influence of external electric field on basic magnetic properties and an influence of external magneticfield on basic thermodynamic properties of the studied lattice-statistical models. A response of magnetic systemon a change of external electric and magnetic fields will be investigated mainly in a vicinity of phase transitions(including quantum ones), where particularly interesting behaviour can be expected. The rigorous theoreticalresults will contribute to a deeper understanding of both studied cooperative phenomena, what enables topropose a subsequent optimalization of technologically important properties of multifunctional materials andmagnetic refrigerants.
Duration:	1.1.2016 – 31.12.2019

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Mezoškálové javy a štruktúry v mäkkých látkach polymérneho a nepolymérneho charakteru,
Program:	VEGA
Project leader:	RNDr. Sedlák Marián, DrSc.
Duration:	1.1.2017 – 31.12.2019

Supramolecular complexes of biomacromolecules
Supramolekulárne komplexy biomakromolekúl
Program:	VEGA
Project leader:	RNDr. Valušová Eva, PhD.
Annotation:	Cells have numerous examples of nonmembrane-bound compartments containing many biomacromolecules. However, their physicochemical properties play an important role in a number of biological processes, but their complex biochemistry still remain poorly understood. These granules exhibit liquid-like behavior. Two or more biomacromolecules that interact with each other form liquid droplets in which their concentration is higher than in the surrounding aqueous medium. Furthermore, high concentrations of solutes, ions and also some low – molecular weight molecules contribute to mesoscale organization in certain biological systems. The project is devoted to address processes allowing preparing and characterization physicochemical properties of supramolecular complex models of nonmembrane-bound compartments and will also concentrate on mechanisms that occur during these processes.
Duration:	1.1.2016 – 31.12.2019

Influence of extreme conditions on strongly correlated electron systems
Vplyv extrémnych podmienok na silne korelované elektrónové systémy.
Program:	VEGA
Project leader:	doc. RNDr. Gabáni Slavomír, PhD.
Annotation:	Strong correlations between free (conduction) and bound (localized) electrons in a condensed matter can be change or modified by extreme conditions (very low temperatures, high pressures and magnetic fields), what often leads to the creation of new/exotic states/effects in these materials. In this proposal, we will experimentally study the newest open problems in strongly correlated electron systems (SCES), as surface conductivity in topological Kondo insulators, dynamics of frustrated antiferromagnets, Kondo vs. spin-polaron model in spin glasses, superconductivity under pressure. All this will be a very time-consuming research on new-produced samples.
Duration:	1.1.2016 – 31.12.2019

Development of new procedures for the reconstruction and analysis of the data from the proton-proton collisions at the LHC
Vývoj nových postupov pre rekonštrukciu a analýzu dát z protón-protónových zrážok na urýchľovači LHC
Program:	VEGA
Project leader:	RNDr. Stríženec Pavol, CSc.
Annotation:	Theoretical as well as methodological contribution to studies of proton interactions at LHC accelerator, which was just upgraded to a new, so far the highest energy of proton-proton collisions, is proposed in this project. The project goal is to contribute to the improvements of existing reconstruction and analysis procedures, as well as to bring up new aspects from theoretical and methodological points of view. The main contribution to methodology will be the improvement of the hadronic calibration of the ATLAS calorimeter. Contribution to the accuracy improvement of b-jet charge calibration is also foreseen. We assume three main contributions to the analysis, namely improvements of the top-quark charge measurement, searches for Higgs boson and searches for Standard Model (SM) extensions, as well as to obtain improved data to study Bose-Einstein correlations between the pions produced in proton collisions.
Duration:	1.1.2016 – 31.12.2019

GONanoplatform – Graphene-based nanoplatform for detection of cancer
Grafénová nanoplatforma na detekciu rakoviny
Program:	SRDA
Project leader:	Ing. Koneracká Martina, CSc.
Annotation:	This project proposal reflects current technological progress and new opportunities in biomedical applications ofgraphene-based sensors. Our main goals include the design and development of a graphene oxidemultifunctional nanoplatform (GO-MFN) for the detection of tumor cells. In the first step, the development ofgraphene oxide nanoflakes of appropriate size functionalized by monoclonal antibody is planned. For sensingthe tumor cells, GO-MFN of 100 nm size able to interact with a single cell will be prepared. Magneticnanoparticles added to GO-MFN will enable the inspection of deep tissues by nuclear magnetic resonance. Thedegree of oxidation of GO, type of the functional groups, optimal functionalization with covalently boundmonoclonal antibodies and magnetic nanoparticles, are the most important technological steps. The analysis ofthe basic interactions related to tumor sensing will be conducted in vitro on 2D and 3D cell models up to theproof-of-principle stage that will be directly applicable to laboratory and preclinical testing. The GO-MFNinteraction with the cell membrane and with the cell interior will be analysed with subcellular resolution. Such anapproach will bring original knowledge and a detailed understanding of the tumor sensing process that isimportant for the optimization of the sensor sensitivity. Detection of biomolecules bound to GO-MFN will be addressed in real time by several techniques.The project is based on a complex multidisciplinary approach, ranging from physics and chemistry up tobiomedicine and combining excellent science and the most sophisticated nano and bio-engineering. Theinvolved partners possess key skills, infrastructure, antibodies and tumor models, and are highly motivated toreach the project goals.
Duration:	1.7.2015 – 30.6.2019

PSI – Superconductor – insulator transition
Prechod supravodič – izolant
Program:	SRDA
Project leader:	Mgr. Szabó Pavol, CSc.
Annotation:	The project aims at understanding the problem of how superconductor transforms to insulator at increaseddisorder. The questions of what is the force driving the superconducting transition temperature to lower values inultrathin superconducting films and what is the mechanism of the quantum phase transition betweensuperconducting and insulating states will be addressed experimentally as well as theoretically. Thesuperconducting films of various content with thicknesses down to few atomic layers as well as thenanostructures and resonators on their basis will be prepared. Transport, microwave and optical properties ofthese objects will be investigated. By means of the subkelvin scanning tunnelling microscope the spectral mapsof the quasiparticle density of states at ultralow temperatures and in high magnetic fields will be measured. Wewill explore possibilities to prepare sensitive photon detectors and amplifiers based on ultrathin disorderedsuperconducting films for the spectroscopy in physics, chemistry and biology.Dynamics of the surface states in another macroscopic quantum object, the superfluid 3He which is thetopological insulator at ultra low temperatures, will be investigated experimentally as well as theoretically. Theobjective is to elucidate the dynamics of surface bound excitations in superfluid 3He by means of mechanicalresonators and resolve if the excitations can be identified with the long searched Majorana fermions.By experiment the recent question if samarium hexaboride is a topological insulator will be addressed.
Duration:	1.7.2015 – 30.6.2019

NANOSIMKA – Effects of nanoencapsulated simvastatin on cardiovascular system in experimental metabolic syndrome
Účinok nanoenkapsulovaného simvastatínu na kardiovaskulárny systém pri experimentálnom metabolickom syndróme
Program:	SRDA
Project leader:	Ing. Závišová Vlasta, PhD.
Annotation:	High level of cholesterol in the blood increases the risk of heart and vascular diseases. Simvastatin reduces cholesterol production in the liver thus reduces the blood cholesterol level. Long-term use of statins has been associated with the occurrence of side effects, which in addition increase with increasing their dose. In particular, the statin side effect include mainly inhibition of the endogenous synthesis of CoQ10 – basic cofactor for ATP synthesis and paradoxically activation of PCSK9 – an important enzyme for the synthesis of LDLcholesterol.The project aims to increase the bioavailability of simvastatin in the liver, thus reducing the daily dose and consequently to prevent the reduction of CoQ10 levels as well as to block the activation of PCSK9. In order to achieve this this aim, nano-encapsulated simvastatin together with nano-encapsulated CoQ10 or PCSK9 inhibitor, or in the polymer with antioxidant properties will be prepared, tested and applied. This ensuresthe targeted transport of simvastatin to the liver simultaneously with CoQ10, or inhibitor of PCSK9, or simultaneous increase in antioxidant capacity. In the case of successful results the proposed project may uncover new possibility of using nanocarriers for the treatment of metabolic and cardiovascular diseases.
Duration:	1.7.2015 – 30.6.2019