Contacts
Intranet
SK
International
| Vývoj a charakterizácia biokeramických systémov modifikovaných termosetovými biopolymérmi | |
| Development and characterization of bioceramic systems modified by thermosetting biopolymers | |
| Program: | Mobility |
| Project leader: | RNDr. Sopčák Tibor, PhD. |
| Annotation: | Development of biomaterials consisting of bioceramics as matrix enriched with various polymers is a long-standing challenge when preparing synthetic bone substitutes. The combination of both materials can serve several purposes: the inorganic ceramic phase ensures the outstanding bioactivity, osteoconductivity and osteoinductivity, while the polymer component is responsible for the enhanced mechanical reinforcement and improved biodegradation. In view of above, the present project will be oriented towards the production and characterization of bioceramic systems modified with a thermoset biopolymer coating. A great emphasis will be givenon the synthesis of polyol citrate thermosetting polymers and their effective incorporation on the surface of bioceramic matrix. Beside that, a detailed analysis of the effect of polymer addition on the microstructural, phase, mechanical, and in-vitro cellular properties of bioceramic systems will be thoroughly studied using several characterization techniques. It is anticipated, that our results shouldexpand knowledge in the field of polymer/bioceramic composites and will provide useful directions in their further design for potentialuse in biomedicine. |
| Duration: | 1.1.2023 – 31.12.2024 |
National
| AMA3DEUS – Pokročilé keramické povlaky pre 3D tlačené titánové implantáty | |
| Advanced Ceramic Coatings for 3D Printed Titanium Implants | |
| Program: | SRDA |
| Project leader: | RNDr. Strečková Magdaléna, PhD. |
| Annotation: | A patient\’s body\’s effective acceptance of biomaterial is greatly influenced by the interaction between the material\’s surface and the host environment. Direct structural and functional connection is created between a bone and the surface of a load-bearing implant after implantation without interfering with soft tissue. Therefore, successful osseointegration is crucial for implants\’ long-term stability and functionality. In the case of orthopedic scaffolds, surface treatment may improve their osseointegration. Ceramics, particularly bioactive ones (hydroxyapatite, e.g.) can be engineered with specific surface morphologies and porosities that enhance cell attachment and proliferation. Moreover, the unique 3D design of the implant affects load distribution and its mechanical stability. Mimicking the natural anatomy of the bone can also improve biomaterial integration and the healing process. However, in some cases, the body may recognize the implant as a foreign object, triggering an immune response that can lead to chronic inflammation and discomfort. Thus, incorporating drug delivery systems within the implant coating design can provide localized delivery of osteogenic or antimicrobial agents, enhancing bone healing and reducing infection risk. In the opening stage of the project, a novel titanium (Ti6Al4V) alloy implant design will be proposed and the scaffolds will be produced by additive manufacturing using the selective laser melting (SLM) method. Then, different types of ceramic coatings (hydroxyapatite, bredigit, calcium-doped silicates e.g.) will be applied to the material surface using different methods including electrochemical deposition and sol-gel technique. Lastly, ceramics will be enhanced with antibacterial agents (antibiotics, silver, e.g.) to improve its antibacterial effect. Surface morphology, chemical composition, degradation properties, and biological properties of the prepared specimens will be tested and evaluated. |
| Duration: | 1.9.2025 – 31.12.2028 |
| CASOPUR – Kalcium fosfátové cementy s prídavkom esenciálnych olejov prostredníctvom termosetových polyesterov určených na regeneráciu tvrdých tkanív | |
| Calcium phosphate cements incorporating essential oils through thermosetting polyesters used for hard tissue regeneration | |
| Program: | Plán obnovy EÚ |
| Project leader: | RNDr. Sopčák Tibor, PhD. |
| Annotation: | Over the past few years, the interest in bone regenerative materials with antimicrobial properties has increased, since prosthesis infection is one of the most usual complications in implant surgery. Despite the increasing number of synthetic drugs with antibiotic and anti-inflammatory effects, research interest in natural substances, such as essential oils (EOs), remains still high. The terpenes and terpenoids found in essential oils represent a potential alternatives to synthetic drugs used for bone and joint healing, thanks to high inflammatory effect and the ability to inhibit bone resorption, subsequently leading to an increase of the bone mineral density. Hence the incorporation of terpene EOs into frequently used bone substitute materials, such as calcium phosphate cements, represent a significant challenge addressed by the proposed CASOPUR project. The novelty and main contribution of the project will concern on the stabilization of EOs through citrate-based polyesters synthesis via esterification reactions, followed by deposition onto the CPC matrix using a solution infiltration technique. This approach offers an effective strategy for creating homogeneous polymer coatings on the cement matrix and developing polymer/CPC systems functionalized with natural EOs. The resulting biocomposites will exhibit not only improved physicochemical properties but will also support the healing and regeneration of bone tissue. The project aims to provide calcium phosphate bone cement with antimicrobial activity without harming its bone regenerative capability. Overall, the successful outcome of this project holds the potential to provide a bone-filling material for use in bone tissue engineering and regenerative medicine. An important aspect of such biomaterials is their potential to significantly reduce the risk of post-operative infections in patients undergoing orthopedic surgeries, thus enhancing the patients comfort and safety during these procedures. |
| Duration: | 1.9.2024 – 31.8.2026 |
| VEGA – Kalcium fosfátové biocementy s biologicky aktívnou kvapalnou zložkou | |
| – | |
| Program: | VEGA |
| Project leader: | MVDr. Giretová Mária, PhD. |
| Annotation: | The project is focused on research and characterization of calcium phosphate biocements with hardening liquid containing conditioned medium. The intention is to assess the influence of conditioned medium containing biologically active molecules in connection with biocement on the final properties of the biocement, its structure, phase transformations and also the influence of biocement system on stimulation, proliferation and cell activity, assuming to improve bone defect healing in vivo. |
| Duration: | 1.1.2023 – 31.12.2025 |
| HERO – Elektrokatalyzátory pre efektívnu produkciu vodíka pre budúce elektrolyzéry a palivové články | |
| Hydrogen evolution electrocatalysts for future electrolyser and fuel cells | |
| Program: | SRDA |
| Project leader: | RNDr. Strečková Magdaléna, PhD. |
| Annotation: | The development of activities in the field of hydrogen technologies was also supported by the EuropeanCommission in the strategic document "Hydrogen Strategy for a Climate Neutral Europe". Today, Slovakia hassuggested own national hydrogen strategy. Already in 2015, the National Hydrogen Association has founded tosupport research, implementation and use of hydrogen technologies. The Hydrogen Technology Center is beingestablished in Košice with the main "Power-to-Gas" concept using renewable power energy sources with nonegative impact on human life and without dependence on fossil fuels. A significant source of hydrogen is waterand the electrolysis of water is the most promising technology for hydrogen production. However, before it can berecognized as an economically significant resource for large scale application with an exceptional energy potential,the simple, efficient, and secure methods of hydrogen retrieval have to be developed. For the time being, the mostefficient electrocatalysts in terms of overpotential for hydrogen evolution reaction (HER) are noble metals.Unfortunately the high cost and scarcity of noble metals motivate the scientists to find the rival low-costalternatives. Intrinsic structures of TMP meet the criteria of outstanding electrocatalysts that could further improve their HER performance in membrane electrode assembly. Excellent dispersity of electrocatalysts allows full use ofactive sites on catalysts to participate in electrode reaction to improve the electrocatalytic efficiency. Therefore, themain challenge in this project is to reduce the production cost of HER and at the same time to maintain the highefficiency of polymer electrode water electrolysis. Substantial aim of the project will be devoted to improve the PEM water electrolysis components mainly electrode materials based on modified carbon fibers electrocatalysts result in the technology which should be more approached to commercial markets. |
| Duration: | 1.7.2021 – 30.6.2025 |
| DEBIORE – Degradovateľné kovové biomateriály s riadeným uvoľňovaním liečiv | |
| Degradable metallic biomaterials with controlled drug release | |
| Program: | SRDA |
| Project leader: | RNDr. Kupková Miriam, CSc. |
| Duration: | 1.7.2021 – 31.12.2024 |
| Komponat – Kompozitné biomateriály s komplexnými prírodnými aditívami | |
| Composite biomaterials with complex natural additives | |
| Program: | SRDA |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Annotation: | The project is focused on the research of modified and new types of composite biocements with complex natural additives, which will self-hardened as well as injectable according to the need for use and will be characterized by high bioactivity and biocompatibility with bone tissue. In principle, the preparation of composite biocement systems is applied in combination with complex natural additives without specific extraction of selected groups of compounds from natural products what preserves the simplicity of preparation, cheap final form of biomaterial as well as the "green principle" of their nature, composition and response. Composite biocements will be used inorthopedics (treatment of bone and osteochondral defects and fractures) as well as in the reconstruction of bone injuries in the facial part or as filling cements in dentistry. |
| Duration: | 1.7.2021 – 30.6.2024 |
| Kompozitné systémy na báze bioelastomérov a bioaktívnych fáz | |
| Composite systems based on bioelastomers and bioactive phases | |
| Program: | VEGA |
| Project leader: | RNDr. Sopčák Tibor, PhD. |
| Annotation: | As the population continues to grow, so does the number of surgeries in various fields of medicine, including reconstructive surgery and regenerative medicine. This implies a need for a research of such biomaterials that will closely mimic the structure of the original tissue. The present project will aim to address the issues related to the currently used bone implants, i.e. low mechanical properties with the simultaneous maintenance of their biological properties. The production of composite systems based on bioelastomers and bioactive phases in the form of bioceramics or cements is expected to take advantage of both components with the outstanding bioactivity, self-setting and handling properties of cements along with excellent elastic properties, mechanical reinforcement and improved biodegradation offered by elastomers. A great emphasis will be given on the production of glycerol carboxylate polyesters and their effective incorporation into the bioactive matrix. |
| Duration: | 1.1.2021 – 31.12.2023 |
| Kompozitné horčíkovo-vápenato fosforečné biocementy s prídavkom koloidného oxidu kremičitého | |
| Composite magnesium-calcium phosphate biocements with addition of colloidal silicon dioxide | |
| Program: | VEGA |
| Project leader: | Ing. Štulajterová Radoslava, PhD. |
| Annotation: | The project is focused on the research and development of composite calcium phosphate biocements containing magnesium and colloidal silica particles, which represents an improvement in particular, in the viscositycharacteristics of cement pastes. The intention is that the addition of colloidal SiO2 will contribute to a fastertransformation of calcium phosphate biocement to calcium deficient hydroxyapatite and change or improving the biocement characteristics, which are important in bone reconstruction. Resulting biocement system should haveenhanced mechanical strength that would be sustained over a longer time period during soaking in body fluids and should positively affect bioresorption with an active influence on specific cell lineages. |
| Duration: | 1.1.2020 – 31.12.2022 |
| VIFKDBB – Výskum inovatívnych foriem liečenia kostných defektov prepojením bioaktívnych biomateriálov s autológnymi rastovými faktormi | |
| Research of innovative forms treatment of bone defects by joining bioactive biomaterials and autologous growth factors | |
| Program: | Vedecko-technické projekty |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Duration: | 15.12.2018 – 14.12.2021 |
| INJEHYB – Injektovateľné hybridné kompozitné biocementy | |
| Injectable hybrid composite biocements | |
| Program: | SRDA |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Annotation: | Project is focused on synthesis, preparation and characterization of modified and novel types of injectable hybridbiocements with high bioactivity, structure and chemical biocompatibility with required properties for medicalapplications. Above biomaterials will have widely utilization in orthopeadics (therapy of bone defects andfractures, stabilization of endoprosthesis etc.), for reconstruction of bone injuries in maxillofacial region and like bioactive adhezive cements in dentistry. |
| Duration: | 1.8.2018 – 30.6.2021 |