Contacts
Intranet
SK
International
| NCM – Kompozity s novými funkčnými a štruktúrnymi vlastnosťami prostredníctvom nanomateriálov | |
| Composites with Novel Functional and Structural Properties by Nanoscale Materials (Nano Composite Materials-NCM) | |
| Program: | COST |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Duration: | 1.1.2008 – 31.3.2012 |
| Inovatívne materiály na báze kalcium fosfátov pre medicínu | |
| Innovative Calcium Phosphate based Materials for Medicine | |
| Program: | Inter-academic agreement |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Duration: | 1.9.2006 – 30.9.2009 |
National
| Biokompozitný cement s vitamínom K pre regeneráciu kostí | |
| Biocomposite cement with vitamin K for bone regeneration | |
| Program: | VEGA |
| Project leader: | Ing. Štulajterová Radoslava, PhD. |
| Annotation: | The project focuses on the research and development of calcium phosphate cement/starch/vitamin K composites with optimized composition. The aim is to achieve higher mechanical strength that remains stable even after soaking in body fluids. At the same time, the release of vitamin K should significantly contribute to the mineralization and regeneration of bone tissue. The project will study the release of vitamin K from phospholipid vesicles embedded in a composite cement paste based on tetracalcium phosphate/starch. It will also analyze the relationship between particle character and the final properties of biocements, which are crucial for their use in regenerative and reconstructive medicine. |
| Duration: | 1.1.2025 – 31.12.2027 |
| HoneyChit – Inovatívne biopolymérne materiály s prírodnými aditívami pre liečbu popálenín a chronických rán | |
| Innovative biopolymer materials with natural additives for the treatment of burns and chronic wounds | |
| Program: | SRDA |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Annotation: | The project is focused on research and testing of new types of biopolymer materials with natural additives, aimed at the regeneration of soft tissues (primarily skin). The main intention is to design, prepare and test materials that will be characterized by their high bioactivity and biocompatibility with the skin, simplicity of preparation, cheap final form, as well as the possibility of adding a cellular and acellular components, corresponding to the requirements of reconstructive and burn surgery. |
| Duration: | 1.7.2024 – 30.6.2027 |
| VEGA – Kalcium fosfátové biocementy s biologicky aktívnou kvapalnou zložkou | |
| – | |
| Program: | VEGA |
| Project leader: | MVDr. Giretová Mária, PhD. |
| Duration: | 1.1.2023 – 31.12.2025 |
| CAMBIOMAT – Chorioalantoická membrána – in vivo model pre štúdium biokompatibility materiálov | |
| Chorioallantoic membrane – in vivo model for study of biocompatibility of materials | |
| Program: | SRDA |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Annotation: | Tissue engineering is a combination of cells, biochemical, physico-chemical factors and biomaterials to improve orreplace of biological functions. Many definitions of tissue engineering cover applications, in practice the term isclosely associated with applications that repair or replace portions of or whole tissues (cartilage, bone, bloodvessels, skin, muscle, nerve, etc.). Often, the tissues involved require certain mechanical and structural propertiesfor proper functioning which biomaterials have to guarantee. For the testing of biomaterial, the various methods areused in relation to their biocompatibility with individual organisms. Chicken embryo /or quail embryo is aninteresting, recognized a very suitable animal model for studying angiogenesis by ex ovo or in ovo method. This isa low-tech method, which makes it possible to continuously monitor angiogenesis, to easily and quickly obtainresults, and to evaluate them in a short time. The project of basic research is focused on the study of angiogenesisof biopolymer composites based on polysaccharides with or/without the hydrogel component implanted on thechick or/quail chorioallantoic membrane using macroscopic, histological, immunohistochemical and molecularmethods. Modern and advanced scientific approach of developing new biomaterials used in the present project ischaracterized by tight multidisciplinary connection of biomaterial engineering methods and in vivo studied systems that with high probability allow assess their suitability as a models for testing biomaterials on angiogenesis. |
| Duration: | 1.7.2021 – 30.6.2025 |
| Komponat – Kompozitné biomateriály s komplexnými prírodnými aditívami | |
| Composite biomaterials with complex natural additives | |
| Program: | SRDA |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Annotation: | The project is focused on the research of modified and new types of composite biocements with complex natural additives, which will self-hardened as well as injectable according to the need for use and will be characterized by high bioactivity and biocompatibility with bone tissue. In principle, the preparation of composite biocement systems is applied in combination with complex natural additives without specific extraction of selected groups of compounds from natural products what preserves the simplicity of preparation, cheap final form of biomaterial as well as the "green principle" of their nature, composition and response. Composite biocements will be used inorthopedics (treatment of bone and osteochondral defects and fractures) as well as in the reconstruction of bone injuries in the facial part or as filling cements in dentistry. |
| Duration: | 1.7.2021 – 30.6.2024 |
| Kompozitné systémy na báze bioelastomérov a bioaktívnych fáz | |
| Composite systems based on bioelastomers and bioactive phases | |
| Program: | VEGA |
| Project leader: | RNDr. Sopčák Tibor, PhD. |
| Annotation: | As the population continues to grow, so does the number of surgeries in various fields of medicine, including reconstructive surgery and regenerative medicine. This implies a need for a research of such biomaterials that will closely mimic the structure of the original tissue. The present project will aim to address the issues related to the currently used bone implants, i.e. low mechanical properties with the simultaneous maintenance of their biological properties. The production of composite systems based on bioelastomers and bioactive phases in the form of bioceramics or cements is expected to take advantage of both components with the outstanding bioactivity, self-setting and handling properties of cements along with excellent elastic properties, mechanical reinforcement and improved biodegradation offered by elastomers. A great emphasis will be given on the production of glycerol carboxylate polyesters and their effective incorporation into the bioactive matrix. |
| Duration: | 1.1.2021 – 31.12.2023 |
| Kompozitné horčíkovo-vápenato fosforečné biocementy s prídavkom koloidného oxidu kremičitého | |
| Composite magnesium-calcium phosphate biocements with addition of colloidal silicon dioxide | |
| Program: | VEGA |
| Project leader: | Ing. Štulajterová Radoslava, PhD. |
| Annotation: | The project is focused on the research and development of composite calcium phosphate biocements containing magnesium and colloidal silica particles, which represents an improvement in particular, in the viscositycharacteristics of cement pastes. The intention is that the addition of colloidal SiO2 will contribute to a fastertransformation of calcium phosphate biocement to calcium deficient hydroxyapatite and change or improving the biocement characteristics, which are important in bone reconstruction. Resulting biocement system should haveenhanced mechanical strength that would be sustained over a longer time period during soaking in body fluids and should positively affect bioresorption with an active influence on specific cell lineages. |
| Duration: | 1.1.2020 – 31.12.2022 |
| VIFKDBB – Výskum inovatívnych foriem liečenia kostných defektov prepojením bioaktívnych biomateriálov s autológnymi rastovými faktormi | |
| Research of innovative forms treatment of bone defects by joining bioactive biomaterials and autologous growth factors | |
| Program: | Vedecko-technické projekty |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Duration: | 15.12.2018 – 14.12.2021 |
| INJEHYB – Injektovateľné hybridné kompozitné biocementy | |
| Injectable hybrid composite biocements | |
| Program: | SRDA |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Annotation: | Project is focused on synthesis, preparation and characterization of modified and novel types of injectable hybridbiocements with high bioactivity, structure and chemical biocompatibility with required properties for medicalapplications. Above biomaterials will have widely utilization in orthopeadics (therapy of bone defects andfractures, stabilization of endoprosthesis etc.), for reconstruction of bone injuries in maxillofacial region and like bioactive adhezive cements in dentistry. |
| Duration: | 1.8.2018 – 30.6.2021 |
| Biomimeticky vytvrdzované hydrogél/kalcium fosfátové cementy | |
| Biomimetically hardened hydrogel/calcium phosphate cements | |
| Program: | VEGA |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Annotation: | The project is focused on research and development of hydrogel / calcium phosphate cements with optimized content of calcium and phosphate ions concentrated in hydrogels. This arrangement allows biomimetic precipitation of calcium phosphate nanoparticleswith specific ordering, which will affect the strength of the interface, microstructure and properties of cement composites. The objective of the project will be research and development of new method for creating of larger pores using resorbable macroporous particles added to the cement paste and analysis relation of characterstics of cement particles on the final cement properties. Final systems will mimic the composition of bone tissue and imitate the ossification processes of bone tissue formation via hydrogel component. |
| Duration: | 1.1.2017 – 31.12.2019 |
| Hybridné kompozitné systémy s bioskelnou zložkou | |
| Hybrid composite systems with bioglass component | |
| Program: | VEGA |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Annotation: | Project is focused on research and development of hybride composite systems with bioglass component applicable in reconstruction and regenerative medicine. The aim of the project is a more detailed analysis of relationships between interaction of various types of polymer phase, synthesized during preparation ofcomposites, with surface of bioglass particles and its influence on microstructure, mechanical properties and biodegradation of composites. An important part of the project is study of nanohybride composites with homogeneous silico-organic matrix formed by sol-gel synthesis. |
| Duration: | 1.1.2014 – 31.12.2016 |
| Biocementy na báze kompozitov s aktívnym rozhraním kalcium fosfát- biopolymér | |
| Biocements on composite basis with active calcium phosphate-biopolymer interface | |
| Program: | VEGA |
| Project leader: | Ing. Medvecký Ľubomír, DrSc. |
| Annotation: | It was analysed the influence of the chitosan addition to calcium phosphate biocement on hardening process, microstructure formation and mechanical properties of composite.The effect of polyhydroxybutyrate microparticles addition into biocement on mechanical and physico-chemical properties was studied hereby with modification of the preparation process from the point ofview of final mechanical properties, which were increased about 50% in comparison with pure biocement. The carbonated nanohydroxyapatite was synthesized via tetrabutylammonium hydroxide addition. New three component macroporouspolyhydroxybutyrate-chitosan-hydroxyapatite system was developed with suitable in-vitro bioactivity and excluding of high toxic halogen solvents. |
| Duration: | 1.1.2008 – 31.12.2010 |