Projects

International

COST MP1005 – Pórovité kompozitné biomateriálové substráty typu biopolymér-kalcium fosfát pre regeneratívnu medicínu
Porous composite biomaterial substrates biopolymer-calcium phosphate type for regenerative medicine
Program: COST
Project leader: Ing. Medvecký Ľubomír, DrSc.
Duration: 30.3.2012 – 30.3.2015
Kalcium fosfátové biomateriály využiteľné v lekárstve
Calcium phosphate based biomaterials utilized in medicine
Program: Inter-academic agreement
Project leader: Ing. Medvecký Ľubomír, DrSc.
Duration: 17.12.2009 – 16.12.2012
NCM – Kompozity s novými funkčnými a štruktúrnymi vlastnosťami prostredníctvom nanomateriálov
Composites with Novel Functional and Structural Properties by Nanoscale Materials (Nano Composite Materials-NCM)
Program: COST
Project leader: Ing. Medvecký Ľubomír, DrSc.
Duration: 1.1.2008 – 31.3.2012
IMPROVING – Posilnenie výskumných kapacít Ústavu materiálového výskumu v Košiciach
Improving the research capacity of the Institute of materials research in Košice
Program: FP7
Project leader: prof. RNDr. Dusza Ján, DrSc.
Duration: 1.3.2009 – 28.2.2010
Inovatívne materiály na báze kalcium fosfátov pre medicínu
Innovative Calcium Phosphate based Materials for Medicine
Program: Inter-academic agreement
Project leader: Ing. Medvecký Ľubomír, DrSc.
Duration: 1.9.2006 – 30.9.2009
ELENA – Štúdium vzájomného vzťahu medzi mikroštruktúrou a vlastnosťami v progresívnych elektrokeramických materiáloch pripravených z nanopráškov
Structure-property Relationship Study in Advanced Nanostructured Electroceramic Materials
Program: COST
Project leader: RNDr. Kovaľ Vladimír, DrSc.
Annotation: no description
Project webpage: www.cost539.cms-bg.net
Duration: 27.5.2005 – 22.6.2009

National

CAMBIOMAT – Chorioalantoická membrána – in vivo model pre štúdium biokompatibility materiálov
Chorioallantoic membrane – in vivo model for study of biocompatibility of materials
Program: SRDA
Project leader: Ing. Medvecký Ľubomír, DrSc.
Duration: 1.7.2021 – 30.6.2025
Komponat – Kompozitné biomateriály s komplexnými prírodnými aditívami
Composite biomaterials with complex natural additives
Program: SRDA
Project leader: Ing. Medvecký Ľubomír, DrSc.
Annotation: The project is focused on the research of modified and new types of composite biocements with complex natural additives, which will self-hardened as well as injectable according to the need for use and will be characterized by high bioactivity and biocompatibility with bone tissue. In principle, the preparation of composite biocement systems is applied in combination with complex natural additives without specific extraction of selected groups of compounds from natural products what preserves the simplicity of preparation, cheap final form of biomaterial as well as the "green principle" of their nature, composition and response. Composite biocements will be used inorthopedics (treatment of bone and osteochondral defects and fractures) as well as in the reconstruction of bone injuries in the facial part or as filling cements in dentistry.
Duration: 1.7.2021 – 30.6.2024
Kompozitné systémy na báze bioelastomérov a bioaktívnych fáz
Composite systems based on bioelastomers and bioactive phases
Program: VEGA
Project leader: RNDr. Sopčák Tibor, PhD.
Annotation: As the population continues to grow, so does the number of surgeries in various fields of medicine, including reconstructive surgery and regenerative medicine. This implies a need for a research of such biomaterials that will closely mimic the structure of the original tissue. The present project will aim to address the issues related to the currently used bone implants, i.e. low mechanical properties with the simultaneous maintenance of their biological properties. The production of composite systems based on bioelastomers and bioactive phases in the form of bioceramics or cements is expected to take advantage of both components with the outstanding bioactivity, self-setting and handling properties of cements along with excellent elastic properties, mechanical reinforcement and improved biodegradation offered by elastomers. A great emphasis will be given on the production of glycerol carboxylate polyesters and their effective incorporation into the bioactive matrix.
Duration: 1.1.2021 – 31.12.2023
Kompozitné horčíkovo-vápenato fosforečné biocementy s prídavkom koloidného oxidu kremičitého
Composite magnesium-calcium phosphate biocements with addition of colloidal silicon dioxide
Program: VEGA
Project leader: Ing. Štulajterová Radoslava, PhD.
Annotation: The project is focused on the research and development of composite calcium phosphate biocements containing magnesium and colloidal silica particles, which represents an improvement in particular, in the viscositycharacteristics of cement pastes. The intention is that the addition of colloidal SiO2 will contribute to a fastertransformation of calcium phosphate biocement to calcium deficient hydroxyapatite and change or improving the biocement characteristics, which are important in bone reconstruction. Resulting biocement system should haveenhanced mechanical strength that would be sustained over a longer time period during soaking in body fluids and should positively affect bioresorption with an active influence on specific cell lineages.
Duration: 1.1.2020 – 31.12.2022
Príprava a charakterizácia pórovitých EuTbGd-MOF tenkých filmov pre luminiscenčné senzory.
Preparation and characterization of porous EuTbGd-MOF thin films for luminescent sensors.
Program: VEGA
Project leader: RNDr. Bruncková Helena, PhD.
Annotation: The project is focused on research of structure of porous metal-organic frameworks (MOFs) based onlanthanides (Ln = Eu, Tb, Gd) in the form of hybrid nanomaterials assembled from Ln3+ ions and organic ligands.Nanocrystalline thin films will be prepared individually with europium, therbium, gadolinium and mixedEuxTbyGdz-MOF system by solvothermal method from precursors deposited on silicon substrates byspin-coating method. Determination of concentration effect of acetate agent as modulator in reducing particle sizeof 3D structure will help to clarify the mechanism of phase transformations occurring in films in the heatingprocess. In addition, the project is focused on characterization of luminescent properties. Eu3+, Tb3+ and Gd3+phosphors emitting red, green and blue light will be incorporated into resulting framework capable of generatingwhite light. The results could help to contribute the knowledge about porous films in terms of their possibleapplication as sensors in the electrotechnical industry.
Duration: 1.1.2020 – 31.12.2022
VIFKDBB – Výskum inovatívnych foriem liečenia kostných defektov prepojením bioaktívnych biomateriálov s autológnymi rastovými faktormi
Research of innovative forms treatment of bone defects by joining bioactive biomaterials and autologous growth factors
Program: Vedecko-technické projekty
Project leader: Ing. Medvecký Ľubomír, DrSc.
Duration: 15.12.2018 – 14.12.2021
INJEHYB – Injektovateľné hybridné kompozitné biocementy
Injectable hybrid composite biocements
Program: SRDA
Project leader: Ing. Medvecký Ľubomír, DrSc.
Annotation: Project is focused on synthesis, preparation and characterization of modified and novel types of injectable hybridbiocements with high bioactivity, structure and chemical biocompatibility with required properties for medicalapplications. Above biomaterials will have widely utilization in orthopeadics (therapy of bone defects andfractures, stabilization of endoprosthesis etc.), for reconstruction of bone injuries in maxillofacial region and like bioactive adhezive cements in dentistry.
Duration: 1.8.2018 – 30.6.2021
Biomimeticky vytvrdzované hydrogél/kalcium fosfátové cementy
Biomimetically hardened hydrogel/calcium phosphate cements
Program: VEGA
Project leader: Ing. Medvecký Ľubomír, DrSc.
Annotation: The project is focused on research and development of hydrogel / calcium phosphate cements with optimized content of calcium and phosphate ions concentrated in hydrogels. This arrangement allows biomimetic precipitation of calcium phosphate nanoparticleswith specific ordering, which will affect the strength of the interface, microstructure and properties of cement composites. The objective of the project will be research and development of new method for creating of larger pores using resorbable macroporous particles added to the cement paste and analysis relation of characterstics of cement particles on the final cement properties. Final systems will mimic the composition of bone tissue and imitate the ossification processes of bone tissue formation via hydrogel component.
Duration: 1.1.2017 – 31.12.2019
Vplyv lantanoidov na štruktúru a nanomechanické vlastnosti pyrochlórových polymorfných Ln(Nb, Ta)O4 tenkých filmov pripravených sol-gel procesom.
Effect of lanthanides on structure and nanomechanical properties of pyrochlore polymorphic Ln(Nb, Ta)O4 thin films prepared by sol-gel process.
Program: VEGA
Project leader: RNDr. Bruncková Helena, PhD.
Annotation: The project is focused on research of structure of transparent nanocrystalline thin films based on lanthanides withNb and Ta in form of pyrochlore niobates and tantalates with ferroelastic properties. Polymorphic LaNbO4 andLaTaO4 films will be prepared individually and with addition of other lanthanides by sol-gel process fromprecursors deposited on silicon substrates using spin-coating method. Determination of effect of Nd, Sm, Eu andGd components on structure of both systems will help to clarify mechanism of phase transformation occurring infilms in heating process. In addition, the project is focused on characterization of mechanical properties offilm/substrate systems by nanoindentation and the relationship between them. Elastic modulus and hardness ofsimple LaNbO4 and LaTaO4 films will be determined from their composite values. The results could help tocontribute the knowledge about ferroelastic films in terms of their possible application as solid electrolytes in theelectrotechnical industry.
Duration: 1.1.2017 – 31.12.2019
Fázové transformácie v sol-gel R1/3(Nb, Ta)O3 keramike a tenkých filmoch na báze prvkov vzácnych zemín
Phase transformation in sol-gel R1/3(Nb, Ta)O3 ceramics and thin films based on rare earth elements.
Program: VEGA
Project leader: RNDr. Bruncková Helena, PhD.
Annotation: The main part of the project is concerned on the study of sol-gel processes during preparation of R1/3MO3 (R = La, Nd, Eu and M = Nb, Ta) precursors perovskite ceramics and thin films and the influence on polymeric M-complex on phase composition, microstructure and mechanical properties. La1/3NbO3 and La1/3TaO3 thin films will be prepared by spin-coatingmethod onto the SiO2/Si substrates from sols with different solvent (methanol, ethanol) and chelating agent (citric, tartaric acid) synthetized by polymeric complex sol-gel process. At preparation rare-earth precursos R (R = La, Nd and Eu) will be studied influence of the transformation temperature of pyrochlore R3MO7 and RMO4 phase on perovskite R1/3MO3 in final ceramics and nanocrystalline films. In addition the project will be oriented on the study of evolution of the morphology and nanoparticle size and measurement of the mechanical properties of ceramic systems by nanoindentation.
Duration: 1.1.2014 – 31.12.2016
Hybridné kompozitné systémy s bioskelnou zložkou
Hybrid composite systems with bioglass component
Program: VEGA
Project leader: Ing. Medvecký Ľubomír, DrSc.
Annotation: Project is focused on research and development of hybride composite systems with bioglass component applicable in reconstruction and regenerative medicine. The aim of the project is a more detailed analysis of relationships between interaction of various types of polymer phase, synthesized during preparation ofcomposites, with surface of bioglass particles and its influence on microstructure, mechanical properties and biodegradation of composites. An important part of the project is study of nanohybride composites with homogeneous silico-organic matrix formed by sol-gel synthesis.
Duration: 1.1.2014 – 31.12.2016
Kompozitné systémy biocement-biopolymér s povrchovo aktívnymi aditívami
Composite biocement-biopolymer systems with addition of surfactants
Program: VEGA
Project leader: Ing. Medvecký Ľubomír, DrSc.
Annotation: The aim of project is study of the relation between physico-chemical and mechanical properties of composite withaddition of surfactants during composite biocement-biopolymer systems (calcium phosphatecement-polyhydroxybutyrate) preparation process. The effect of surfactant on particle morphology of formedapatite phase, microstructure of interface between polymeric and inorganic composite components as well as on mechanism of processes in biocement hardening will be more detailed examined.
Duration: 1.1.2011 – 31.12.2013
Vývoj mikroštruktúry a fázová transformácia sol-gel prekurzorov bezolovnatých feroelektrických (K, Na)NbO3 tenkých filmov
Evolution of the microstructure and phase transformation of sol-gel precursors in lead-free ferroelectric (K, Na)NbO3 thin films
Program: VEGA
Project leader: RNDr. Bruncková Helena, PhD.
Annotation: The main part of the project is concerned on the study of processes during preparation of lead-free ferroelectricKNbO3 (KN), NaNbO3 (NN) and (K0.5Na0.5)NbO3 (KNN) thin films from sols and their influence on the phasecomposition and microstructure. Environmental acceptable KNN thin films will be prepared by spin-coatingmethod onto the Al2O3 and SiO2/Si substrates from sols with different concentration, synthetized by sol-gelprocess from acetates of K and Na with polymeric Nb-complex. For the preparation of the films will be appliedmodified Pechini method utilized by Nb-ethylene glycol-tartarate complex instead of the classical citrate method.In addition the project will be oriented on the study of transformation processes on amorphous films afterpyrolysis and final 1-3 layered KNN nanocrystalline films with the perovskite phase and development of theirmicrostructure.
Duration: 1.1.2011 – 31.12.2013
Centrum excelentnosti biomedicínskych technológií
Center of excellence of biomedical technologies
Program: EU Structural Funds Research & Development
Project leader: Ing. Medvecký Ľubomír, DrSc.
Duration: 15.11.2010 – 31.10.2013
Pokročilé implantáty s naočkovanými kmeňovými bunkami na regeneráciu a rekonštrukciu tvrdých tkanív
Advanced implants seeded with stem cells for hard tissue regeneration and reconstruction
Program: EU Structural Funds Research & Development
Project leader: Ing. Medvecký Ľubomír, DrSc.
Duration: 1.1.2010 – 31.3.2012
Biocementy na báze kompozitov s aktívnym rozhraním kalcium fosfát- biopolymér
Biocements on composite basis with active calcium phosphate-biopolymer interface
Program: VEGA
Project leader: Ing. Medvecký Ľubomír, DrSc.
Annotation: It was analysed the influence of the chitosan addition to calcium phosphate biocement on hardening process, microstructure formation and mechanical properties of composite.The effect of polyhydroxybutyrate microparticles addition into biocement on mechanical and physico-chemical properties was studied hereby with modification of the preparation process from the point ofview of final mechanical properties, which were increased about 50% in comparison with pure biocement. The carbonated nanohydroxyapatite was synthesized via tetrabutylammonium hydroxide addition. New three component macroporouspolyhydroxybutyrate-chitosan-hydroxyapatite system was developed with suitable in-vitro bioactivity and excluding of high toxic halogen solvents.
Duration: 1.1.2008 – 31.12.2010
Sol-gel procesy syntézy feroelektrických nanoprekurzorov a ich vplyv na fázové zloženie a mikroštruktúru v tenkých vrstvách
Sol-gel processes of the synthesis of ferroelectric nanoprecursors and their influence on phase composition and microstructure in thin layers
Program: VEGA
Project leader: RNDr. Bruncková Helena, PhD.
Annotation: The main part of the project is concerned on sol-gel processes of the synthesis of nanoprecursors PZT,PMN, PMnN, PFN and PZN ferroelectric ceramics and thin layers and examines their influence on the phasecomposition in final materials. For the preparation of ferroelectric thin layers from sol-gel solutions onto thesubstrate by spin-coating method, hybrid composite slurrries will be synthetised by sol-gel process from organiccomponents by dispersing of nanoprecursors in the sols. Study of the processes of formation of the resultingperovskite phase in thin layers during the thermal treating and the development of the microstructure andanalysis their relationship to physical properties is also part of the project.
Duration: 1.1.2008 – 31.12.2010
Biokompozity na báze hydroxiapatitu s orientovanou štruktúrou
Biokomposites on hydroxiapatite basis with oriented structure
Program: VEGA
Project leader: Ing. Medvecký Ľubomír, DrSc.
Duration: 1.1.2005 – 1.12.2007
Multikomponentné a dotované relaxátorové feroelektrické systémy na báze PZT a PMN s vysokou povrchovou aktivitou a chemickou homogenitou
Multicomponent and doped ferroelectric systems of relaxor type on PZT and PMN basis with high surface activity and chemical homogeneity
Program: VEGA
Project leader: RNDr. Bruncková Helena, PhD.
Duration: 1.1.2005 – 1.12.2007