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| Innovative water-soluble phytomaterial inhibitors for Alzheimer’s and Parkinson’s disease prevention | |
| Innovative water-soluble phytomaterial inhibitors for Alzheimer’s and Parkinson’s disease prevention | |
| Program: | Horizon 2020 |
| Project leader: | MUDr. Musatov Andrey, DrSc. |
| Duration: | 1.10.2022 – 28.2.2025 |
| NOVÉ KOMPOZITY NANOČASTÍC OXIDU CÉRIA A UHLÍKOVÝCH ENTEROSORBENTOV PRE LIEČBU CHORÔB PO AKÚTNOM OŽIARENÍ | |
| NOVEL COMPOSITES BASED ON CERIUM OXIDE NANOPARTICLES AND CARBON ENTEROSORBENTS FOR ACUTE RADIATION SICKNESS THERAPY | |
| Program: | NATO |
| Project leader: | MUDr. Musatov Andrey, DrSc. |
| Duration: | 15.7.2020 – 14.7.2023 |
| Zvýšenie Bioaktivity Nanočastíc Oxidu Céria | |
| Enhancement of Bioactivity of Cerium Oxide Nanoparticles | |
| Program: | Inter-academic agreement |
| Project leader: | MUDr. Musatov Andrey, DrSc. |
| Duration: | 1.1.2020 – 31.12.2021 |
| MAGBBRIS – Nové magnetické biomateriály pre obnovu mozgu a zobrazovanie po mozgovej príhode | |
| New MAGnetic Biomaterials for Brain Repair and Imaging after Stroke | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | By engineering novel magnetic nano-biomaterials we will achieve tissue repair in the context of an ischemic event. We will take advantage of nanotechnology to deliver therapeutic growth factors, secreted by progenitor cells, into the injured brain.According to the World Health Organization, 15 million persons suffer a stroke worldwide eachyear. However, the only available treatment is the acute thrombolytic therapy (pharmacological or mechanical) which is being administered to less than 10% of stroke patients due to strict selectioncriteria. In contrast, neuro-repair treatments could offer the opportunity to include most strokepatients by extending the therapeutic time window.MAGBBRIS will demonstrate that growth factors, secreted by endothelial progenitor cells, with proved potential to induce tissue repair, can be encapsulated in magnetic biomaterials and be successfully and safely transplanted into mouse brains to induce tissue repair. In the ischemic brain, the secretome will be retained by an external magnetic field in the vasculature, improving vascular remodelling and neurogenic tissue regeneration after stroke. |
| Duration: | 1.3.2018 – 28.2.2021 |
National
| Vývoj translačne relevantných regeneračných a reparatívnych stratégií po traumatickom poranení miechy | |
| The development of translationally relevant regenerative and reparative strategies after spinal cord trauma | |
| Program: | SRDA |
| Project leader: | MUDr. Musatov Andrey, DrSc. |
| Duration: | 1.7.2020 – 30.6.2024 |
| Nový pohľad na vplyv hydrofóbnych interakcií na tvorbu a stabilitu proteínových agregátov. Prepojenie na oxidačný stres. | |
| New Insight into the Role of Hydrophobic Interactions in Formation and Stability of Proteins Aggregates. Link to Oxidative Stress. | |
| Program: | VEGA |
| Project leader: | MUDr. Musatov Andrey, DrSc. |
| Duration: | 1.1.2021 – 31.12.2023 |
| MVISION – Nanočastice v anizotrópnych systémoch | |
| Nanoparticles in anisotropic systems | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposal is devoted to study complex anisotropic systems based on thermotropic as well as lyotropic(biological) liquid crystals. Liquid crystals represents the uniq state of matter, which is liquid but posses theanisotropic properties. The structuralization phenomena in such systems play key role in fundamental as well asin applied research. The main aim is to s influence the sensitivity of these anisotropic systems to externalmagnetic field, what will be done by adding suitable magnetic nanoparticles and open the way for theirapplications in magneto-optical devices. |
| Duration: | 1.7.2016 – 31.12.2020 |
| Oxidačný stres a fosfolipidovo-proteínové interakcie: funkčné a štrukturálne dôsledky | |
| Functional and Structural Insights into the Phospholipid-Protein Interaction during Oxidative Stress | |
| Program: | VEGA |
| Project leader: | MUDr. Musatov Andrey, DrSc. |
| Annotation: | Mitochondria play a critical role in cells metabolism and mitochondrial dysfunction has long been implicated in age-related neurodegenerative diseases. One currently accepted theory is that damage to mitochondria, the main source of reactive oxygen species (ROS), initiates these diseases. In fact, when ROS levels overpower the cell’s defenses (oxidative stress), proteins, nucleic acids and/or lipids are irreversibly damaged. Particularly important is that oxidative stress disrupts or modifies the protein-lipid interactions what is one of the essential features of normal cell operation. Such disruptions could be a decisive factor leading to ROS-induced diseases. To test this hypothesis and clearly elucidate the links between mitochondrial oxidative stress and cells dysfunction we propose to investigate both, (i) the role of phospholipid modification in ROS-induced damage to mitochondrial electron transport Complex IV, and (ii) the role of phospholipids and oxidatively modified phospholipids in amyloidogenesis. |
| Duration: | 1.1.2017 – 31.12.2020 |
| Funkčná a štruktúrna integrita proteínov v dvojvrstvových micelách – aplikácia na mitochondriálne a amyloidogénne proteíny | |
| Functionality and Structural Integrity of Proteins in Bicelles – Implications for Mitochondrial and Amyloidogenic Proteins | |
| Program: | VEGA |
| Project leader: | MUDr. Musatov Andrey, DrSc. |
| Duration: | 1.1.2014 – 31.12.2016 |