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| SeNaTa – Magnetické nanoštruktúrne materiály schopné samozahrievania pre teranostické aplikácie | |
| Self-heating magnetic nanoconstructs for theranostic applications | |
| Program: | Bilateral – other |
| Project leader: | RNDr. Kubovčíková Martina , PhD. |
| Annotation: | Cancer is still one of the leading causes of death worldwide, therefore significant research and innovation efforts are still needed to find new materials and methods for better cancer diagnosis and treatment. Magnetic nanoparticles (MNPs) appear to be a very promising material for use in many medical fields, such as in nanosurgery they can be used to kill tumor cells by increasing drug concentration in target cells in combination with hyperthermia as well. The presented project is focused on the development of new nanoconstructs labeled by radionuclide as a potential theranostic agent for radiotherapy and diagnostics. The first step to achieve the desired goal will be the synthesis of nanoconstructs consisting of self-heating magnetic nanoparticles coated with various biocompatible substances, which will exhibit the desired bioactivity as well. The prepared nanoconstructs will be studied by several physicochemical methods, and their stability and suitability for magnetic hyperthermia, i.e. the ability to produce heat in an alternating magnetic field, will be monitored. In the second step, nanoconstructs with the best properties will be radiolabeled with therapeutic 177Lu and diagnostic 99mTh radionuclides to prepare radioactive nanoconstructs for dual therapy and diagnosis. In the next step, in vitro toxicity testing of nanoconstructs labeled with radionuclides will be performed. The prepared magnetic magnetic nanostructured materials labeled with radionuclides will contribute to the improvement of diagnostics and therapy of cancer diseases. The project is based on a complex multidisciplinary approach, from physics, chemistry to biochemistry and biomedicine. The involved partners possess key skills, infrastructure and are highly motivated to achieve the project goals. |
| Duration: | 1.7.2023 – 30.6.2025 |
| MultiFunMag – Návrh a príprava multifunkčných magnetických nanočastíc na detekciu nádorových buniek | |
| Design and preparation of multifunctional magnetic nanoparticles for the cancer cell detection | |
| Program: | Multilateral – other |
| Project leader: | Ing. Závišová Vlasta, PhD. |
| Annotation: | Cancer is the second leading cause of death after cardiovascular disease in almost all European countries. Over the past several decades, the principle types of cancer therapies have been chemotherapy, radiation therapy and surgery. This project is focused on the development of biocompatible multifunctional magnetic nanoparticles and evaluation of their diagnostic andtherapeutic potential for the application in oncology. The first step to achieve the desired goals will be the synthesis of magnetic nanoparticles and the functionalization of their surface with a suitable biocompatible materials suitable for radiotracer binding. Several physicochemical methods will be used to optimize the preparation of biocompatible multifunctional magnetic nanoparticles (MNPs). At the same time, we will study the suitability of multifunctional magnetic nanoparticles for magnetic resonance imaging and magnetic hyperthermia application as well. Considering the application purposes of biocompatible multifunctional magnetic nanoparticles, biodistribution studies of radiotracer conjugated MNPs will be conducted. The prepared radiotracer conjugated MNPs will improve the efficacy of cancer diagnosis and treatment. Moreover, combination of MRI, hyperthermia and radiotherapy represents a significant advance in cancer diseases treatment and a substantial improvement in survival of oncological patients. The project is based on a complex multidisciplinary approach,ranging from physics, chemistry up to biochemistry and biomedicine. The involved partners possess key skills, infrastructure and are highly motivated to reach the project goals. |
| Duration: | 1.3.2020 – 31.12.2022 |
| CAMBIOMN – Komplementárne analytické metódy na určenie biodistribúcie magnetických nanočastíc | |
| Complementary analytic methods for the determination of the biodistribution of the magnetic nanoparticles | |
| Program: | Bilateral – other |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | The main objective of the proposed project is focused on the design and synthesis of magneticnanoparticles as a potential candidate for hyperthermia, transport delivery and chemotherapy/radiotherapytreatment. The special effort is devoted to their biodistribution investigation due to the combination ofcomplementary physico-analytical methods. Basic concept includes procedures (i) to obtain well-definedmagnetic nanoparticles available for medical applications, (ii) to characterize the products under welldefinedand reproducible conditions, (iii) to develop proper combination of physico-analytical methodstowards detailed biodistribution analyses. In the context of the proposed project, special effort will befocused on the systematic study of the optimization of magnetic nanoparticles synthesis with suitablefunctional properties and sufficient response to the selected analytical methods for determination of theirbiodistribution. It is expected that such attitude will result in protocol for preparation and studybiodistribution of magnetic nanoparticles in as low as possible concentrations that could significantlydecrease undesirable side effects of treatment. Besides that, such project will significantly contribute to the(i) bilateral cooperation and transfer of knowledge between experts in chemistry, physics, biology andpharmacy; (ii) the optimization of the real structure and bioaccumulation investigation of the preparedproducts; (iii) presentation and publication of common results on high impact factor journals and important international conferences; (iv) networking/base for further cooperation in highly attractive scientific fieldregarding biophysics/nanomedicine. |
| Duration: | 1.1.2019 – 31.12.2021 |
National
| Funkcionalizované magnetické nanočastice pre MRI zobrazovanie distribúcie liečiva v pľúcach pri experimentálnom syndróme akútnej respiračnej tiesne (ARDS) | |
| Functionalized magnetic nanoparticles for MRI imaging of drug distribution in the lungs in experimental acute respiratory distress syndrome (ARDS) | |
| Program: | VEGA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | The current project is focused on the synthesis and functionalization of magnetic nanoparticles (MNPs) for MRIimaging of the drug N-acetylcysteine distribution in the lungs in experimental acute respiratory distress syndrome(ARDS). The first step will be to prepare a conjugate consisting of MNPs modified with functional groups suitablefor drug conjugation. MNPs functionalization and drug conjugation will be optimized and studied byphysicochemical methods such as UV/Vis and IR spectroscopy, microscopy, calorimetry or magneticmeasurements. In the next phase, the conjugate will be analyzed by MRI and compared with the properties ofcommercially available MRI contrast agents. In the third step, the relevant ARDS model will be created, and theconjugate will be applied to the lungs. Finally, the conjugate will be imaged using optimized MRI techniques tostudy the drug distribution in the lungs in ARDS. The output items of the project have a direct application potentialfor clinical practice. |
| Duration: | 1.1.2023 – 31.12.2026 |
| Funkcionalizácia magnetických nanočastíc na detekciu rakovinových buniek | |
| Functionalization of magnetic nanoparticles for cancer cell detection | |
| Program: | VEGA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | The presented project is focused on the preparation of a magnetic biocomplex that specifically detects cancer cells; it penetrates into their structure and enables better visualization of the affected areas, using magneticresonance imaging (MRI), for example. The surface of synthetized magnetic nanoparticles will be functionalized bydifferent amino acids. Several physicochemical methods (spectroscopic, microscopic, calorimetric, magnetic andothers) will be used to optimize the nanoparticle functionalization. We will also study the suitability of usingmodified nanoparticles for MRI. The next step will be the conjugation of a specific antibody to the functionalizednanoparticles (biocomplex) and the study of cell interaction with biocomplex by immunochemical methods.Considering the application purposes of magnetic nanoparticles, one of our goals will be investigation the effect ofprepared magnetic biocomplexes on cell viability in combination with magnetic hyperthermia. |
| Duration: | 1.1.2019 – 31.12.2022 |