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| SeNaTa – Magnetické nanoštruktúrne materiály schopné samozahrievania pre teranostické aplikácie | |
| Self-heating magnetic nanoconstructs for theranostic applications | |
| Program: | Bilateral – other |
| Project leader: | RNDr. Kubovčíková Martina , PhD. |
| Annotation: | Cancer is still one of the leading causes of death worldwide, therefore significant research and innovation efforts are still needed to find new materials and methods for better cancer diagnosis and treatment. Magnetic nanoparticles (MNPs) appear to be a very promising material for use in many medical fields, such as in nanosurgery they can be used to kill tumor cells by increasing drug concentration in target cells in combination with hyperthermia as well. The presented project is focused on the development of new nanoconstructs labeled by radionuclide as a potential theranostic agent for radiotherapy and diagnostics. The first step to achieve the desired goal will be the synthesis of nanoconstructs consisting of self-heating magnetic nanoparticles coated with various biocompatible substances, which will exhibit the desired bioactivity as well. The prepared nanoconstructs will be studied by several physicochemical methods, and their stability and suitability for magnetic hyperthermia, i.e. the ability to produce heat in an alternating magnetic field, will be monitored. In the second step, nanoconstructs with the best properties will be radiolabeled with therapeutic 177Lu and diagnostic 99mTh radionuclides to prepare radioactive nanoconstructs for dual therapy and diagnosis. In the next step, in vitro toxicity testing of nanoconstructs labeled with radionuclides will be performed. The prepared magnetic magnetic nanostructured materials labeled with radionuclides will contribute to the improvement of diagnostics and therapy of cancer diseases. The project is based on a complex multidisciplinary approach, from physics, chemistry to biochemistry and biomedicine. The involved partners possess key skills, infrastructure and are highly motivated to achieve the project goals. |
| Duration: | 1.7.2023 – 30.6.2025 |
| FMF – Flexibilné magnetické vlákna: Vlastnosti a aplikácie | |
| Flexible Magnetic Filaments: Properties and Applications | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | Different technologies for synthesis of flexible magnetic filaments are developed. These include linking magnetic micro-particles by DNA, attaching magnetic nanoparticles to polyelectrolyte bundles, extraction of magnetosomes from magnetotactic bacteria and other. Flexible magnetic filaments are interesting for applications as self-propelling microdevices(for targeted transport), micro-mixers (for microfluidics), different sensors(micro rheology). Numerical algorithms for predicting their behavior in magnetic fields of different configurations will be developed, including algorithms based on curve dynamics, lattice Boltzmann method, Brownian dynamics. Obtained numerical results will be compared with experimental results of measurement of flows fields around magnetic filaments, their buckling instabilities. As a result new technology will be developed for DLS measurements giving access to characteristics of translation and rotational motion of string like magnetic micro-objects. |
| Duration: | 1.9.2018 – 31.12.2022 |
| MultiFunMag – Návrh a príprava multifunkčných magnetických nanočastíc na detekciu nádorových buniek | |
| Design and preparation of multifunctional magnetic nanoparticles for the cancer cell detection | |
| Program: | Multilateral – other |
| Project leader: | Ing. Závišová Vlasta, PhD. |
| Annotation: | Cancer is the second leading cause of death after cardiovascular disease in almost all European countries. Over the past several decades, the principle types of cancer therapies have been chemotherapy, radiation therapy and surgery. This project is focused on the development of biocompatible multifunctional magnetic nanoparticles and evaluation of their diagnostic andtherapeutic potential for the application in oncology. The first step to achieve the desired goals will be the synthesis of magnetic nanoparticles and the functionalization of their surface with a suitable biocompatible materials suitable for radiotracer binding. Several physicochemical methods will be used to optimize the preparation of biocompatible multifunctional magnetic nanoparticles (MNPs). At the same time, we will study the suitability of multifunctional magnetic nanoparticles for magnetic resonance imaging and magnetic hyperthermia application as well. Considering the application purposes of biocompatible multifunctional magnetic nanoparticles, biodistribution studies of radiotracer conjugated MNPs will be conducted. The prepared radiotracer conjugated MNPs will improve the efficacy of cancer diagnosis and treatment. Moreover, combination of MRI, hyperthermia and radiotherapy represents a significant advance in cancer diseases treatment and a substantial improvement in survival of oncological patients. The project is based on a complex multidisciplinary approach,ranging from physics, chemistry up to biochemistry and biomedicine. The involved partners possess key skills, infrastructure and are highly motivated to reach the project goals. |
| Duration: | 1.3.2020 – 31.12.2022 |
| MAGBIO – Magnetické nanokompozity pre biomedicínu | |
| Magnetic nanocomposites for biomedicine | |
| Program: | Bilateral – other |
| Project leader: | RNDr. Zentková Mária, CSc. |
| Annotation: | Multidisciplinary project is devoted to synthesis and characterization of magnetite and manganite based magnetic nanocomposites with application potential for hyperthermia. Magnetic nanoparticles produced by various synthetic routes will be functionalized by methods of surface chemistry and tested for amount of the heat loss in the presence of alternating current magnetic field at frequencies and amplitudes causing no harm to patients. Aspects of biocompatibility and nontoxicity of prepared nanocomposites will be studied as well. |
| Duration: | 15.2.2019 – 31.12.2021 |
National
| Funkcionalizované magnetické nanočastice pre MRI zobrazovanie distribúcie liečiva v pľúcach pri experimentálnom syndróme akútnej respiračnej tiesne (ARDS) | |
| Functionalized magnetic nanoparticles for MRI imaging of drug distribution in the lungs in experimental acute respiratory distress syndrome (ARDS) | |
| Program: | VEGA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | The current project is focused on the synthesis and functionalization of magnetic nanoparticles (MNPs) for MRIimaging of the drug N-acetylcysteine distribution in the lungs in experimental acute respiratory distress syndrome(ARDS). The first step will be to prepare a conjugate consisting of MNPs modified with functional groups suitablefor drug conjugation. MNPs functionalization and drug conjugation will be optimized and studied byphysicochemical methods such as UV/Vis and IR spectroscopy, microscopy, calorimetry or magneticmeasurements. In the next phase, the conjugate will be analyzed by MRI and compared with the properties ofcommercially available MRI contrast agents. In the third step, the relevant ARDS model will be created, and theconjugate will be applied to the lungs. Finally, the conjugate will be imaged using optimized MRI techniques tostudy the drug distribution in the lungs in ARDS. The output items of the project have a direct application potentialfor clinical practice. |
| Duration: | 1.1.2023 – 31.12.2026 |
| NANOVIR – Nanočastice pre riešenie diagnosticko-terapeutických problémov s COVID-19 (NANOVIR) | |
| – | |
| Program: | Štrukturálne fondy EÚ Výskum a inovácie |
| Project leader: | Ing. Závišová Vlasta, PhD. |
| Project webpage: | https://websrv.saske.sk/uef/veda-a-vyskum/projekty-v-ramci-opvai/nanovir/ |
| Duration: | 3.3.2021 – 30.6.2023 |
| Funkcionalizácia magnetických nanočastíc na detekciu rakovinových buniek | |
| Functionalization of magnetic nanoparticles for cancer cell detection | |
| Program: | VEGA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | The presented project is focused on the preparation of a magnetic biocomplex that specifically detects cancer cells; it penetrates into their structure and enables better visualization of the affected areas, using magneticresonance imaging (MRI), for example. The surface of synthetized magnetic nanoparticles will be functionalized bydifferent amino acids. Several physicochemical methods (spectroscopic, microscopic, calorimetric, magnetic andothers) will be used to optimize the nanoparticle functionalization. We will also study the suitability of usingmodified nanoparticles for MRI. The next step will be the conjugation of a specific antibody to the functionalizednanoparticles (biocomplex) and the study of cell interaction with biocomplex by immunochemical methods.Considering the application purposes of magnetic nanoparticles, one of our goals will be investigation the effect ofprepared magnetic biocomplexes on cell viability in combination with magnetic hyperthermia. |
| Duration: | 1.1.2019 – 31.12.2022 |
| Makroskopicky anizotrópne kompozity na báze kvapalnych kryštálov a magnetických nanočastíc | |
| Macroscopic anisotropic composites based on liquid crystals and magnetic nanoparticles | |
| Program: | VEGA |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | The proposal targets basic research on composite materials consisting of liquid crystals and various magnetic nanoparticles. Combination of the anisotropic properties of liquid crystals with the magnetic properties of the nanoparticles results in composites with unique magnetic and optical properties that the component materials themselves do not possess. The proposed studies concentrate on the increase of the sensitivity of our composite soft matter materials (liquid state) to magnetic fields and prepare new materials having unique dielectric, magnetic and optical properties. The main goal of the proposal is to influence the sensitivity of these anisotropicsystems to external magnetic field by adding suitable magnetic nanoparticles and by this way make a step forward towards potential applications in various magneto-optical or dielectric devices as for example sensors of low magnetic fields or light shutter. |
| Duration: | 1.1.2017 – 31.12.2020 |