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| Identifikácia štruktúrnych motívov malých molekúl schopných inhibovať amyloidnú agregáciu amyloidogénnych proteínov s rozdielnou konformáciou | |
| Identification of small molecule motifs effective to inhibit amyloid aggregation of conformationally diverse amyloidogenic proteins | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Gažová Zuzana, DrSc. |
| Annotation: | Amyloid-related diseases, including systemic lysozyme amyloidosis, Alzheimer\’s disease and diabetes melitus, are characterized by the amyloid aggregation of proteins with distinct conformations. This project aims to identifysmall molecules capable of reducing the amount of amyloid aggregates of poly/peptides with diverse native conformation. We will focus on both globular proteins (lysozyme and insulin) and intrinsically disordered protein(IDP) (Aß peptides and tau). The project\’s objectives include assessing the anti-amyloid potential of smallmolecules, evaluating their cytotoxicity, and elucidating the relationship between their structural motifs and anti-amyloid effects. Attention will be given to small molecules with key structural motifs identified in our previousstudies (a conjugated system of aromatic rings, a catechol moiety, planarity, and carboxyl groups) and their hybrid complexes. Thus, the project could pave the way for the development of novel therapeutics for amyloid-related diseases. |
| Duration: | 1.1.2025 – 31.12.2028 |