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| Hyp4Amy – Ultrazvukom a magneticky indukovaná hypertermia ako liečebná modalita pre amyloidné ochorenia | |
| Ultrasound- and Magnetic-induced Hyperthermia as a Treatment Modality for Amyloid-related Diseases | |
| Program: | Bilateral – other |
| Project leader: | RNDr., Ing. Šipošová Katarína, PhD. |
| Annotation: | Nanoparticles (NPs), including those with magnetic properties, have attracted significant scientific interest due totheir applications in various fields of science and medicine. As a consequence, several promising treatmentprocedures have been developed, such as controlled and local drug delivery and release, photo- and sonodynamictherapy, and thermal therapy. NPs can also be used as biosensors or imaging contrast agents. Additionally, theyare being studied for their potential role in amyloidogenic diseases. Although great efforts have been made tounderstand the pathogenesis of these diseases and design effective therapy, there is still no treatment for amyloid -related diseases. A possible alternative non-pharmacological option for targeting cross -using energy generated by magnetic NPs as a result of applied magnetic field and/or ultrasound to disrupt largeamyloid structures (plaques) into smaller fragments. This proposal is aimed at basic as well as applied researchthat will help perfect the application of magnetic NPs in the treatment of amyloid-related diseases via thermal andultrasound-induced processes and enable tomography imaging of amyloid formation/decomposition. Efficaciousdrug/NPs deposition in the target site and operated activation of therapeutic and imaging agents reduce treatmenttime, while avoiding adverse damage and side effects resulting from systemic administration. The collaboration willnot only promote the bilateral exchange of knowledge, technology and experience, but also may accelerate thetranslation between biophysical/biochemical science and clinical study. |
| Duration: | 1.1.2024 – 31.12.2025 |
National
| NANOFLIT – Nano-funkcionalizácia kvapalín pre olejové transformátory | |
| Nano-functionalization of liquids for liquid-immersed transformers | |
| Program: | SRDA |
| Project leader: | RNDr. Rajňák Michal, PhD. |
| Annotation: | The current increase in electricity consumption and the greening of its distribution, together with the increase in the price of materials for the production of distribution transformers, represent a challenge for applied research in electric power engineering. The intention of the presented project is to respond to this challenge by functionalizing the current liquids used in electrical transformers in order to increase their cooling efficiency while maintaining or improving their dielectric and insulating properties. For this project, the liquids used in the distribution transformers of the manufacturer interested in this research will be selected. These are commercial liquids primarily based on liquefied natural gas, synthetic and natural esters. Based on current state of the art, the liquids will be functionalized by means of nanotechnologies and nanomaterials, which can significantly improve thermal conductivity, natural and thermomagnetic convection, and thus make the overall heat transport in the liquids more efficient. The functionalizing nanoadditives will be mainly made from carbon (fullerene, nanodiamond) and iron oxides or other ferromagnetic elements. The functionalized liquids will undergo laboratory measurements of physico-chemical, electrical, magnetic and thermal properties. Based on the analyzes of laboratory experiments and numerical simulations, nanofluids with the greatest potential for improving the thermal and insulating properties of the transformer will be selected. The selected nanofluids will be tested by the industrial partner (the customer of the research results) and applied in the selected distribution transformer. The transformer will be subjected to electrical and temperature rise tests. One can expect that the nanofunctionalization of the liquids will result in a lower operating temperature of the transformer, which can lead to an extension of the transformer service life and to the production of smaller transformers. |
| Duration: | 1.7.2023 – 30.6.2027 |