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| AZCAI – Anti-amyloidná aktivita kompozitov na báze zeolitov a analýza so zobrazovaním vo vysokom rozlíšení a v reálnom čase | |
| Anti-amyloid activity of zeolite-based composites and analysis with real-time 3d super-resolution imaging | |
| Program: | JRP |
| Project leader: | RNDr., Ing. Šipošová Katarína, PhD. |
| Annotation: | A common feature associated with most of neurodegenerative diseases, including Alzheimer’s disease is the formation of extended, β-sheet rich amyloid fibrils. Today, amyloid-related diseases are incurable and the treatment is only symptomatic without feasibility to stop or substantially delay the progressive consequences of the diseases. Magnetic nano/micro-particles based on clinoptilolite-type of natural zeolite (CZ) jointly developed are expected to serve synergistic therapy approaches act as carriers for controlled drug delivery/release, imaging and local heating in biological systems, that can effectively decompose the amyloid-like fibrillar structures. The micro and mesopores of the natural zeolite can serve as containers for delivering various drugs to the target site to release. Magnetic CZ (MCZs) will improve drug delivery process, real-time monitoring of drug distribution surrounding a targeting side of tissue, as well as the subsequent effects of the therapeutics on the progression of diseases. In addition, fluorescent MCZs in combination with ultrasonic, magnetic or laser irradiation effects will provide hyperthermia and photoreaction to achieve both diagnosis and therapy. The Taiwanese research team has been deeply cultivated in temporal focusing multiphoton microscopy (TFMPM), which imaging frame rate can achieve up to a hundred hertz. We will use the deep learning method to improve the imaging frame rate for real-time biomedical analysis. Within this project, animal models (including genetic rodent models) will be utilized to develop a theranostic system for for inhibition and destruction of amyloid aggregates and super-resolution imaging of MZC induced amyloid aggregate inhibition/destruction effects by state-of-art temporally and spatially super-resolution 3D imaging technology. |
| Duration: | 1.1.2022 – 31.12.2024 |
| FMF – Flexibilné magnetické vlákna: Vlastnosti a aplikácie | |
| Flexible Magnetic Filaments: Properties and Applications | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | Different technologies for synthesis of flexible magnetic filaments are developed. These include linking magnetic micro-particles by DNA, attaching magnetic nanoparticles to polyelectrolyte bundles, extraction of magnetosomes from magnetotactic bacteria and other. Flexible magnetic filaments are interesting for applications as self-propelling microdevices(for targeted transport), micro-mixers (for microfluidics), different sensors(micro rheology). Numerical algorithms for predicting their behavior in magnetic fields of different configurations will be developed, including algorithms based on curve dynamics, lattice Boltzmann method, Brownian dynamics. Obtained numerical results will be compared with experimental results of measurement of flows fields around magnetic filaments, their buckling instabilities. As a result new technology will be developed for DLS measurements giving access to characteristics of translation and rotational motion of string like magnetic micro-objects. |
| Duration: | 1.9.2018 – 31.12.2022 |
| NANOConVEX CIG – – Nanokvapaliny pre zariadenia na prenos tepla prúdením NANOConVEX CIG | |
| Nanofluids for convective heat transfer devices NANOConVEX CIG | |
| Program: | COST |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | In this project we would like to use the obtained results and experiences in application magnetic nanofluids prepared by our group in high power transformers with the intention of lowering of working temperature, increasing of heat dissipation from the transformer core at preservation its insulation characteristics. This fact will have the influence on the lifetime and lowering the cost reduction during the operation. |
| Duration: | 1.5.2020 – 30.4.2021 |
| MAGBBRIS – Nové magnetické biomateriály pre obnovu mozgu a zobrazovanie po mozgovej príhode | |
| New MAGnetic Biomaterials for Brain Repair and Imaging after Stroke | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | By engineering novel magnetic nano-biomaterials we will achieve tissue repair in the context of an ischemic event. We will take advantage of nanotechnology to deliver therapeutic growth factors, secreted by progenitor cells, into the injured brain.According to the World Health Organization, 15 million persons suffer a stroke worldwide eachyear. However, the only available treatment is the acute thrombolytic therapy (pharmacological or mechanical) which is being administered to less than 10% of stroke patients due to strict selectioncriteria. In contrast, neuro-repair treatments could offer the opportunity to include most strokepatients by extending the therapeutic time window.MAGBBRIS will demonstrate that growth factors, secreted by endothelial progenitor cells, with proved potential to induce tissue repair, can be encapsulated in magnetic biomaterials and be successfully and safely transplanted into mouse brains to induce tissue repair. In the ischemic brain, the secretome will be retained by an external magnetic field in the vasculature, improving vascular remodelling and neurogenic tissue regeneration after stroke. |
| Duration: | 1.3.2018 – 28.2.2021 |
| AMAZON – Dynamické štúdium amyloidnej agregácie proteínov pomocou magnetických zeolitových nanočastíc | |
| Dynamical study of formation/destruction of protein amyloid aggregatess targeted by magnetic zeolite nanocomposites | |
| Program: | JRP |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | Abnormal protein aggregation and accumulation of formed fibrils are characteristic features for a range of, if not all, neurodegenerative disorders such as Alzheimer’s, Huntington’s, Parkinson’s, as well as non-neuropathic amyloidosis. Nanoparticles (NPs), attributed to its particularities in sizes, chemical composition and surface properties, have already been found effective in influencing amyloid fibrils. Our preliminary results acquired on amyloid fibrils incubated with in-laboratory synthesized Fe3O4 nanoparticles (MNPs) indicated reductive potential of MNPs on formation of amyloid fibrils, and also suggested facilitation of inhibiting preformation and eradication of amyloid fibrils may be plausible when the fibrils are exposed to external radiation in presence of MNPs. Also, with our previously reported photoluminescence properties of natural zeolite (CZ) which is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional ability to adsorb various atoms, organic molecules and nanoparticles into micro- and mesopores, we plan to apply the MNPs with CZ, developing multiphoton excitation microscopy (MPEM), and other appropriate instruments to establish the dynamical investigation of amyloid fibril formation and remodeling in real time. Prior to in vivo experiment, cytotoxicity in different type of cells and animal models such as zebrafish and mice will be evaluated. |
| Duration: | 1.1.2018 – 31.12.2020 |
| NANOUPTAKE – Prekonanie bariiér pre komerčné využitie nanokvapalín (NANOUPTAKE) | |
| Overcoming Barriers to Nanofluids Market Uptake ( NANOUPTAKE) | |
| Program: | COST |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | Nanofluids are defined as fluids that contain nanometre-sized particles with enhanced heat transfer properties. Nanofluids improve the efficiency of heat exchange and thermal energy storage. In addition, nanofluids fall within one of the Key Enabling Technologies (KET) supported by the European Commission. Although some nanofluid commercial applications currently exist, most of the current nanofluids are at Technological Readiness Levels (TRL) 1 to 3. Most of the nanofluids research in COST countries has been conducted by Research, Development and Innovation (R+D+i) centres through national funding. Additional coordinated research and development efforts are required to develop nanofluids up to higher TRL levels and to overcome commercial application barriers. If these barriers are overcome, nanofluids will be an important player in the Value Added Materials (VAM) for the energy sector.The objective of the NANOUPTAKE COST Action is to create a Europe-wide network of leading R+D+i institutions, and of key industries, to develop and foster the use of nanofluids as advanced heat transfer/thermal storage materials to increase the efficiency of heat exchange and storage systems. |
| Project webpage: | http://www.cost.eu/COST_Actions/ca/CA15119 |
| Duration: | 19.4.2016 – 18.4.2020 |
| Synthesis and comparison of properties of Fe3O4 and (La,Sr)MnO3 nanoparticles and magnetic fluids based on them | |
| – | |
| Program: | Inter-institute agreement |
| Project leader: | RNDr. Timko Milan, CSc. |
| Duration: | 1.1.2018 – 31.12.2019 |
| RADIOMAG – Multifunkcionalizované nanočastice pre magnetickú hypertermiu a nepriamu radiačnú | |
| Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy | |
| Program: | COST |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The Action aims to bring together and to organise the research outcomes from the different participating network members in a practical way to provide clinicians with the necessary input to trial a novel anti-cancer treatment combining magnetic hyperthermia and radiotherapy, also identifying future research objectives upon appraisal of the obtained results. Feedback between the different working groups here is essential, and is expected that the lifetime of this Action proposal will eventually result in a compendium of best practices for magnetic hyperthermia.RADIOMAG will generate new and strengthen the existing synergies between technical advances (thermal imaging / MH), new treatment concepts (combined targeting radiosensitisation and magnetic thermotherapy) and biocompatible coating in order to achieve a breakthrough in the clinical application of magnetic hyperthermia. Due to the complexity of this aim, synergies can only be achieved on a longer time frame, by means of workshops, STSMs, joint publications, common Horizon 2020 research proposals and exchange with other COST Actions (e.g. TD1004, TD1205). |
| Project webpage: | http://www.cost-radiomag.eu/ |
| Duration: | 13.11.2014 – 12.11.2018 |
| MACOSYS – Magneticky aktívne anizotrópne kompozitne systémy | |
| Magnetically active anisotropic composite systems | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposal relates to basic research of anisotropic soft materials sensitive to magnetic fields. The targeted substances are composite materials, so called ferronematics (nematic liquid crystals (LCs) doped with spherical, rod-like, chain-like magnetite nanoparticles, or with carbon nanotubes functionalized with magnetite nanoparticles), and the cross-linked liquid crystalline polymers (elastomers) doped with nanoparticles. The key objectives are: (i) to measure the optical and dielectric responses of these materials to low magnetic fields; (ii) to explore which conditions influence these responses (e.g., bias magnetic field, pretilt, anchoring between the liquid crystal and nanoparticles); (iii) to contribute to the better understanding of the major problem in ferronematics (FNs): the aggregation process; (iv) to enhance the magnetic field induced phase transition temperature shift in a novel type of FNs; (v) to produce mesogenic cross-linked composites sensitive to magnetic fields. |
| Duration: | 1.9.2013 – 31.8.2016 |
| – | |
| Nanoparticles in anisotropic soft matter | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | Liquid crystals and liquid crystalline polymers are anisotropic fluids, and as such they are in general responsive to external stimuli. However, because of the small value of the anisotropy of the diamagnetic susceptibility (~10-7), they require rather high magnetic fields for a measurable response. In an effort to enhance the magnetic susceptibility, the idea of doping with magnetic particles was theoretically introduced more than fourty years ago. The experimental confirmations of the idea followed shortly, however, the results have been mainly found unreproducible indicating that the colloids were not stable. The research on this topic (especially on ferronematics) has been intensified in the last decade, and a number of experimental evidences has been given for obtaining stable composite materials when the concentration of the magnetic nanoparticles is kept low enough. In a recent paper [Soft Matter 7, 4742 (2011)] an experimental confirmation has been given for a measurable optical response of a ferronematic already at magnetic field of about 0.01T. The observation of the response at such a low field is very important for construction of various magneto-optical devices. We expect that our proposed research will contribute to a better understanding of the physics of the anisotropic colloidal systems, which represents the first step in designing materials with improved magnetic properties, and helps to establish the knowledge base to utilize related future technologies. |
| Duration: | 1.1.2013 – 31.12.2015 |
| MAFINCO – Magnetické kvapaliny – nové a chladiace médium pre výkonové transformátory | |
| Magnetic fluid-new Insulated and Cooling medium for power transformers | |
| Program: | ERANET |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | The inhibited transformer oil as insulation fluid in power transformers performs two main functions–insulating, i.e. preventing the flow of electric current between conductive components, and cooling, i.e. transfer the heat out of active transformer components. For currently used insulation fluids, especially those with high dielectric strength (highly refined mineral oils ~ transformer oils), a low thermal conductivity is typical, resulting in low-efficiency cooling, limitation of current intensity in transformer windings what influences its size and weight for a given power rating and in the end increases price of the transformer. The idea using transformer oil based magnetic fluids (MF) as a insulating media with the same or better dielectric properties and better thermal conductivity (magnetic convection) against pure oil can resolve above mentioned problems and so relevantly decrease expenses for construction and operation of transformers. |
| Duration: | 1.1.2009 – 31.12.2011 |
| Fyzika magnetických materiálov – pokračovanie | |
| Physics of magnetic materials – continuation | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | no description |
| Duration: | 1.1.2007 – 31.12.2009 |
| Magnetické nanočastice pre magneto-optické tenké filmy | |
| Magnetic nanoparticles for thin magneto-optical films | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Timko Milan, CSc. |
| Duration: | 1.1.2008 – 31.12.2009 |
| Štúdium fyzikálnych vlastností nanoštruktúrnych magnetických materiálov | |
| Study of physical properties of nanostructured magnetic materials | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | no description |
| Duration: | 1.1.2007 – 31.12.2009 |
| Fyzika magnetických materiálov | |
| Physics of magnetic materials | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | no description |
| Duration: | 1.1.2004 – 31.12.2006 |
| Magnetizovateľné komplexné systémy pre cielený transport liečiv | |
| Magnetizable complex systems for magnetic drug targeting | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | no description |
| Duration: | 1.1.2004 – 31.12.2006 |
| Štúdium fyzikálnych vlastností špeciálnych magnetických materiálov | |
| Study of physical properties of special magnetic materials | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | no description |
| Duration: | 1.1.2004 – 31.12.2006 |
National
| NANOFLIT – Nano-funkcionalizácia kvapalín pre olejové transformátory | |
| Nano-functionalization of liquids for liquid-immersed transformers | |
| Program: | SRDA |
| Project leader: | RNDr. Rajňák Michal, PhD. |
| Annotation: | The current increase in electricity consumption and the greening of its distribution, together with the increase in the price of materials for the production of distribution transformers, represent a challenge for applied research in electric power engineering. The intention of the presented project is to respond to this challenge by functionalizing the current liquids used in electrical transformers in order to increase their cooling efficiency while maintaining or improving their dielectric and insulating properties. For this project, the liquids used in the distribution transformers of the manufacturer interested in this research will be selected. These are commercial liquids primarily based on liquefied natural gas, synthetic and natural esters. Based on current state of the art, the liquids will be functionalized by means of nanotechnologies and nanomaterials, which can significantly improve thermal conductivity, natural and thermomagnetic convection, and thus make the overall heat transport in the liquids more efficient. The functionalizing nanoadditives will be mainly made from carbon (fullerene, nanodiamond) and iron oxides or other ferromagnetic elements. The functionalized liquids will undergo laboratory measurements of physico-chemical, electrical, magnetic and thermal properties. Based on the analyzes of laboratory experiments and numerical simulations, nanofluids with the greatest potential for improving the thermal and insulating properties of the transformer will be selected. The selected nanofluids will be tested by the industrial partner (the customer of the research results) and applied in the selected distribution transformer. The transformer will be subjected to electrical and temperature rise tests. One can expect that the nanofunctionalization of the liquids will result in a lower operating temperature of the transformer, which can lead to an extension of the transformer service life and to the production of smaller transformers. |
| Duration: | 1.7.2023 – 30.6.2027 |
| Procesy samousporiadania v mäkkých hybridných zmesiach kvapalných kryštálov a nanočastíc | |
| Self-organization processes in soft hybrid mixtures of liquid crystals and nanoparticles | |
| Program: | VEGA |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | The proposal aims to approach the research of liquid crystals doped with nanoparticles of different kind from anovel perspective of the self-organization that has an indisputable importance covering all fields of naturalsciences, and has also a deep impact in social sciences. In such composite systems a subtle interplay amongthe nanoparticles, the self-assembling matrix and the topological defects commands the self-organizationprocess. We will focus on the electric/magnetic field induced self-organization in such systems experimentally on different length scales by investigating the processes in different phases, isotropic, nematic, cholesteric with the anticipation that our results can be exploited in applications such as guided material transport, magnetic/electric switches/sensors, chemical/biosensors, in microfluidic/lab-on-a-chip devices, etc. We are convinced that systematic studies in this topic may change fundamentally current knowledge. |
| Duration: | 1.1.2021 – 31.12.2024 |
| NANOELEN – Nanokvapaliny v elektrotechnike | |
| Nanofluids in Electrical Engineering | |
| Program: | SRDA |
| Project leader: | RNDr. Rajňák Michal, PhD. |
| Annotation: | The submitted project is oriented on research into nanofluids based on alternative cooling and insulating liquidmedia such as oils based on liquefied natural gas, natural esters and new types of transformer oils. We willprepare novel nanofluids based on these oils by dispersing magnetic nanoparticles, fullerenes, graphenenanoplatelets or carbon nanotubes. The purpose of the nanofluids preparation is to enhance the coolingeffectiveness of the liquid media. The nanofluids will be investigated from dielectric, insulating, magnetic andheat transfer properties point of view. Finally, their cooling effectiveness will be tested in loaded powertransformers. Therefore, the aim of this project is the development of advanced liquid media for cooling andinsulating in electrical engineering, the application of which will have a potential impact on electric power saving,electrical equipment service life and protection of the environment. |
| Duration: | 1.7.2019 – 30.6.2023 |
| Makroskopicky anizotrópne kompozity na báze kvapalnych kryštálov a magnetických nanočastíc | |
| Macroscopic anisotropic composites based on liquid crystals and magnetic nanoparticles | |
| Program: | VEGA |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | The proposal targets basic research on composite materials consisting of liquid crystals and various magnetic nanoparticles. Combination of the anisotropic properties of liquid crystals with the magnetic properties of the nanoparticles results in composites with unique magnetic and optical properties that the component materials themselves do not possess. The proposed studies concentrate on the increase of the sensitivity of our composite soft matter materials (liquid state) to magnetic fields and prepare new materials having unique dielectric, magnetic and optical properties. The main goal of the proposal is to influence the sensitivity of these anisotropicsystems to external magnetic field by adding suitable magnetic nanoparticles and by this way make a step forward towards potential applications in various magneto-optical or dielectric devices as for example sensors of low magnetic fields or light shutter. |
| Duration: | 1.1.2017 – 31.12.2020 |
| MVISION – Nanočastice v anizotrópnych systémoch | |
| Nanoparticles in anisotropic systems | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposal is devoted to study complex anisotropic systems based on thermotropic as well as lyotropic(biological) liquid crystals. Liquid crystals represents the uniq state of matter, which is liquid but posses theanisotropic properties. The structuralization phenomena in such systems play key role in fundamental as well asin applied research. The main aim is to s influence the sensitivity of these anisotropic systems to externalmagnetic field, what will be done by adding suitable magnetic nanoparticles and open the way for theirapplications in magneto-optical devices. |
| Duration: | 1.7.2016 – 31.12.2020 |
| Interakcia magnetických kvapalín s elektromagnetickým poľom | |
| Interaction of magnetic fluids with electromagnetic field | |
| Program: | VEGA |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | The proposed project will be devoted to the study magnetic principle of heating mechanism – hyperthermia in magnetic nanoparticles systems in dependence on preparation process, size and size distribution and magnetic properties. Besides usually used biocompatible spherical anoparticles as a subjects of this proposal will be special prepared magnetosome and magnetoferritin containing spherical magnetite nanoparticles. The obtainedexperiences for achievement high specific heat power will enable the application magnetic nanoparticles at cancer treatment in biomedicine.We aim to investigate the shielding (absorption and reflection) effects of transformer oil based magnetic fluid.Besides the unique cooling and isolating properties, these magnetic fluids can be reliable shielding medium in electromagnetic devices as well. The research on radiation stability of MFs will address electromagnetic fields and another type radiation. |
| Duration: | 1.1.2016 – 31.12.2019 |
| GONanoplatform – Grafénová nanoplatforma na detekciu rakoviny | |
| Graphene-based nanoplatform for detection of cancer | |
| Program: | SRDA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | This project proposal reflects current technological progress and new opportunities in biomedical applications ofgraphene-based sensors. Our main goals include the design and development of a graphene oxidemultifunctional nanoplatform (GO-MFN) for the detection of tumor cells. In the first step, the development ofgraphene oxide nanoflakes of appropriate size functionalized by monoclonal antibody is planned. For sensingthe tumor cells, GO-MFN of 100 nm size able to interact with a single cell will be prepared. Magneticnanoparticles added to GO-MFN will enable the inspection of deep tissues by nuclear magnetic resonance. Thedegree of oxidation of GO, type of the functional groups, optimal functionalization with covalently boundmonoclonal antibodies and magnetic nanoparticles, are the most important technological steps. The analysis ofthe basic interactions related to tumor sensing will be conducted in vitro on 2D and 3D cell models up to theproof-of-principle stage that will be directly applicable to laboratory and preclinical testing. The GO-MFNinteraction with the cell membrane and with the cell interior will be analysed with subcellular resolution. Such anapproach will bring original knowledge and a detailed understanding of the tumor sensing process that isimportant for the optimization of the sensor sensitivity. Detection of biomolecules bound to GO-MFN will be addressed in real time by several techniques.The project is based on a complex multidisciplinary approach, ranging from physics and chemistry up tobiomedicine and combining excellent science and the most sophisticated nano and bio-engineering. Theinvolved partners possess key skills, infrastructure, antibodies and tumor models, and are highly motivated toreach the project goals. |
| Duration: | 1.7.2015 – 30.6.2019 |
| Citlivosť kvapalných kryštálov s nanočasticami na vonkajšie magnetické pole | |
| Sensitivity of liquid crystals containing nanoparticles to external magnetic field | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposed project will devoted to the study of composite systems of liquid crystal with nanoparticles mainly magnetic particles with the aim to change their sensitivity to external magnetic field. The object of such study will be new kind of liquid crystals with bent-core molecules as well as traditional calamitic liquid crystals with rod-like molecules. Also the influence of magnetic particles on the structural phase transition from isotropic to nematic phase in external magnetic field will be investigated. We suppose this structural transition will be induced by external magnetic field. Moreover, the response of the above mentioned composite systems to low magnetic field (up to 0.1T) will be investigated, which is important for the construction of various magneto-optical devices as for example maping of magnetic fields. |
| Duration: | 1.1.2013 – 31.12.2016 |
| Aplikácia magnetických kvapalín v elektrotechnike | |
| Application of magnetic fluids in electrical engineering | |
| Program: | VEGA |
| Project leader: | RNDr. Timko Milan, CSc. |
| Duration: | 1.1.2012 – 31.12.2015 |
| METAMYLC – Štrukturalizačné javy v systémoch s nanočasticami | |
| Structuralization phenomena in systems with nanoparticles | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The structuralization phenomena plays key role in fundamental as well as in applied research. The proposed project is devoted to the study of the influence of nanoparticles on the structuralization phenomena in various systems as well as on the structuralization of the nanoparticles alone. Some special kinds of nanoparticles will be prepared, which will be used for study these effects. The main aim is to study the influence of the nanoparticles on the structuralization phenomena in two different kind of systems as liquid crystalline mater and amyloid structures. In the first system the magnetic particles can increase the sensitivity of liquid crystals on an external magnetic field. In the amyloid structures the nanoparticles can significantly influence the amyloid aggregation of proteins, which is responsible for amyloid diseases as Alzheimher, Parkinson and Dibetes II The prepared nanoparticles will also be used to build their 3D structures (metamaterials), i.e. to create systems with unusual physical properties as for example negative reflection. |
| Duration: | 1.5.2011 – 31.10.2014 |
| Extrem II – Extrem II – Dobudovanie Centra pokročilých fyzikálnych štúdii materiálov v extrémnych podmienkach | |
| Extrem II – Center of advanced physical studies for materials in extreme conditions | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | RNDr. Skyba Peter, DrSc. |
| Duration: | 28.8.2010 – 31.1.2014 |
| MAGPOL – Magneto-optické vlastnosti polymérnych tenkých filmov | |
| Magneto-optic properties of polymer thin films | |
| Program: | SRDA |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | The aim of this work is to develop magnetically textured magneto-optical thin films (less than 10 microns) with significant Faraday effect and without important attenuation for optical applications. The polymer thin films will be prepared by solidification of PVA polymer doped by magnetic nanoparticles of various shape (spherical, chains and nanorods) and structuralized in external magnetic field. The final goal of such films with non reciprocal effects is to develop optical applications such as integrated isolators and sensors, this long-term goal represents a great challenge. |
| Duration: | 1.1.2012 – 31.12.2013 |
| Centrum excelentnosti výkonových elektronických systémov a materiálov pre ich komponenty II | |
| Center of excellence for power electronics and their material components II | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | RNDr. Timko Milan, CSc. |
| Duration: | 30.9.2010 – 31.8.2013 |
| NMTE – Nové materiály a technológie pre energetiku | |
| New materials and technologies for energetics | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | Ing. Diko Pavel, DrSc., akademik US Slovenska |
| Annotation: | Aims o the project are:1. Technology of nanostructured bulk superconductors for energy storage2. Biological battery based on renewable biological products3. New trafo-steel modified by nanoparticles 4. Cooling and insulating medium based on magnetic fluid for high power transformers |
| Project webpage: | nmte.saske.sk |
| Duration: | 1.5.2010 – 30.4.2013 |
| Dobudovanie centra pre kooperatívne javy a fázové prechody v nanosystémoch s pespektívou využitia v nano- a biotechnológiách | |
| – | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.4.2010 – 31.3.2013 |
| NANOFLUID – Centrum excelentnosti SAV – Nanokvapaliny | |
| Centre excelence of SAS – Nanofluids | |
| Program: | Centrá excelentnosti SAV |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | Centre of NANOFLUIDS is oriented to development of technology of nanoparticles, as are magnetic nanoparticles, coloid gold, nanotubes and their complex characterisation from with aspect to their magnetic and morphologic properties. The prepared nanoparticles will be funcionalised for applications in biomedicine, biotechnology and electrotechnical industry. In the case of biomedical applications the interaction of nanoparticles with biomacromolecules will be investigated, mostly with aspect of the nanohazard, drug targeting delivery, hyperthermia and treatment many human diseases as e.g. Alzheimer\’s diseases, etc. For technical applications the centre will investigate opportunity of application in LCD’s, sensors of magnetic field, as an insulated and cooling medium in high power transformers and converters, exploation multilayered nanotubes and fullerenes as electrodes in device that could converts sun energy into electricity. |
| Duration: | 1.2.2009 – 31.1.2013 |
| NANO-SPIN – Molekulárne mechanizmy interakcií nanočastíc magnetitu po internalizácii a akumulácii v bunkách in vitro | |
| Molecular mechanisms of magnetite nanoparticle interactions due to internalisation and accumulation in cells in vitro | |
| Program: | VEGA |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | Although the magnetite nanoparticles (NP<100 nm) are intensively utilized as nanovectors for targeted drug delivery, their impact on the cell after drug release is still poorly understood. The project is focused on the molecular mechanisms whereby magnetite NP may interact due to internalization into cell in vitro. The precise physical characterization of magnetite nanocolloids, the use of transmission electron microscopy to study NP uptake and distribution in the cell together with information about NP cytotoxicity, NP impact on the genom integrity, oxidative status and cell signalling pathways represents a complex approach. An interdisciplinary approach contributes to improve the understanding of the mechanizms of magnetite NP interactions at cellular, subcellular and molecular levels and allows correlate the biological activity of magnetite NP with their physical parameters and cell localization. A complex approach is important for risk/safty assessment of magnetite NP forhumans and ecosystem |
| Duration: | 1.1.2009 – 31.12.2012 |
| Vplyv rôznych nanočastíc na štruktúrne prechody vo feronematikách a na dielektricke vlastnosti magnetických kvapalín | |
| Influence of different nanoparticles on the structural transitions in ferronematics and dielectric properties of magnetic fluids | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposed project will be devoted to the study of some processes in composite systems containing nanoparticles, namely in magnetic fluids and liquid crystals. The first part of the project will be devoted to liquid crystals doped with magnetic nanoparticles of various shape (spherical, rod-like, chain-like) and different kind of nanoparticles (magnetite, CoZnFeO, as well as new attractive gold and silver particles) with aim to influence their dielectric and optical properties in external magnetic and electric fields. The second part of the project will be deal with the investigation of the dielectric properties, partialdischarges and the both DC and AC dielectric breakdown of novel transformer oil based magnetic fluids with same kind of particles as above mentioned, regarding to the possibility of their application in power transformers. |
| Duration: | 1.1.2009 – 31.12.2012 |
| Vývoj tecnologických postupov magnetických kvapalín pre biomedecínske účely | |
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| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.1.2010 – 30.6.2012 |
| Akustické a hypertermické vlastnosti biokompatibilných magnetických kvapalín | |
| Accoustic and hyperthermic properties of biocompatible magnetic fluids | |
| Program: | SRDA |
| Project leader: | RNDr. Timko Milan, CSc. |
| Duration: | 1.1.2010 – 31.12.2011 |
| Centrum excelentnosti výkonových elektronických systémov a materiálov pre ich komponenty | |
| Center of excellence for power electronics and their material components | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | RNDr. Timko Milan, CSc. |
| Duration: | 25.5.2009 – 24.5.2011 |
| EXTREM I – Extrem – Centrum pokročilých fyzikálnych štúdií materiálov v extrémnych podmienkach | |
| Extrem – Center of advanced physical studies for materials in extreme conditions | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | RNDr. Skyba Peter, DrSc. |
| Duration: | 19.5.2009 – 30.4.2011 |
| Kooperatívne javy a fázové prechody v nanosystémoch s perspektívou využitia v nano- a biotechnológiách | |
| Centre of excelence: Cooperative phenomena and phase transitions in nanosystems with perspective applications in nano- and biotechnology | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 24.4.2009 – 31.3.2011 |
| Súbory magnetických nanočastíc a nanočasticové membrány pre senzorické aplikácie. | |
| Magnetic nanoparticles and nanoparticle membranes for sensor applications. | |
| Program: | Mechanizmus EHP |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | We will obtain new knowledges regarding of the magnetic nanoparticles surfactants and by modification of surfactant we will influence the properties of the nanoparticles. We will obtain new theoretical information about mechanism of photo and mechanical excitation of surfactant molecule and modification of surfactant. We will prepare innovative selfconsistent membranes from magnetic nanoparticles. The shape deformation of membrane immediately after switching on or switching off external magnetic field can be applicable in various areas as new controllable propulsive mechanism, the valves operated by magnetic field, electrochemical sensors, magnetomechanical sensors, colloidal motors or new fine systems for drug dosage. |
| Duration: | 1.9.2008 – 31.10.2010 |
| NANO-SPIN – Hybridné spintronické štruktúry riadené spinovopolarizovaným prúdom | |
| Hybrid Spintronic Nanostructures Controlled by Spin-Polarized Current | |
| Program: | SRDA |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | Spintronic GMR and TMR nanopillars (lateral size 150 nm for current induced magnetization switching (CIMS) studies will be prepared and analyzed. GMR nanopillars will be prepared by UHV deposition and nanoparticles lift off litography and electron beam lotographyu (EBL). Novel TMR nanopillars with embeded nanoparticles will be prepared by UHV evaporation, LB nanoparticles deposition and EBL. . Magnetic configuration of nanopillars will be studied by scanning MOKE microscope. We will study correlation between nanopillar structure, interface roughness (vertical and lateral correlations) and Neel ferromagnetic coupling with magnetic and CIMS behavior with the aim to lower the switching current. Magnetization behavior in situ by its spin polarized current switching will be analyzed by simultaneous measurements of dynamic electrical resistivity vs, current and Kerr rotation vs. magnetic field experiments. |
| Duration: | 1.2.2007 – 31.12.2009 |
| MaNaMag – Magnetické nanočastice pre magnetooptické tenké filmy | |
| Magnetic nanoparticles for magneto-optical thin films | |
| Program: | SRDA |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | The aim of this work is to develop magneto-optical thin films (less than 10 microns) with significant Faraday effect and without important attenuation for optical applications (some particular magnetic materials are able to provide important Faraday effects). In order to produce magneto-optical thin film we have chosen to develop and study doped silica matrix. These films are made using silica-type matrix and nanoparticles by the sol-gel process. The magnetic nanoparticles dispersed as a ferrofluid are introduced in the liquid phase of a compatible sol-gel preparation. The sol-gel approach has been chosen because it allows to produce low-refractive index thin film and to control the refractive index and to use low temperature process compatible with glass-type components. The final goal of such films with non reciprocal effects is to develop optical applications such as integrated isolators and sensors, this long-term goal represents a great challenge. |
| Duration: | 1.2.2008 – 31.12.2009 |
| Magnetoštruktúrne korelácie vo vybraných materiáloch obsahujúcich d- a f- prvky | |
| Magnetostructural correlation in selected materials containing d- and f- elements | |
| Program: | VEGA |
| Project leader: | RNDr. Mihalik Marián, CSc. |
| Annotation: | Our project is focused on the study of magnetostructural correlations in molecule-based magnets synthesized on the base of metal-cyano complexes (MCC) as well as in f- intermetallic compounds and borides. Effect of external parameters like pressure and light on magnetic properties will be studied on single crystals, powders, magnetic nanoparticles and films. Neutron diffraction methods will be used to study details of crystal structure and to study magnetic structure; we will study origin of compensation temperature observed in mixed ferri- ferromagnetic compounds. In the case of f- intermetallic compounds we are going to study non-Fermi liquid behavior (NFL), Kondo lattice, geometric frustration, magnetic anisotropy and long range magnetic ordering. We will focus on effect of chemical substitution, mechanic deformation, pressure and high magnetic field on magnetic properties. We would like to contribute to better description of ground state in selected heavy fermions, Kondo isolators and magnetic semiconductors by tunneling spectroscopy. |
| Duration: | 1.1.2007 – 31.12.2009 |
| SIPS – Vedecký inkubátor pre žiakov a študentov | |
| Scientific Incubator for Pupils and Students | |
| Program: | SRDA |
| Project leader: | RNDr. Zentková Mária, CSc. |
| Annotation: | The scientific incubator for pupils and students is an attempt to influence the public opinion on the role of chemistry and physics in contemporary society. Its target group varies from kindergarten children, pupils and students to their teachers and their teachers programs. |
| Duration: | 1.10.2006 – 31.12.2009 |
| Cielený transport protinádorových liečiv prostredníctvom magneticky značených nanosfér | |
| Targeted transport of anticancer drugs in magnetically labelled nanoparticles | |
| Program: | SRDA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | The objective of this project is the development and evaluation of new delivery systems (of anticancer drug using targeting mechanism of magnetic labelled polymeric carriers), for use as carriers of anticancer drugs using targeting mechanism. Biodegradable nanoparticles based on commercially available polymers loaded with selected anticancer drug(s) will be prepared and characterized with the purpose to enhance the amount of drug reaching target site, prolong circulation time and reduce side effects. The objective is to develop and evaluate new magnetic targeted nanoparticles to be localized in a certain region of the body by applying an external magnetic field. Methodologically the project solves the problem of nanoparticle preparation, drug loading of nanoparticles, encapsulation efficiency and anticancer activity of loaded nanoparticles in vitro and in vivo evaluation, construction and evaluation of target efficiency in animal models. New formulation will be evaluated for safety. |
| Duration: | 1.5.2006 – 1.7.2009 |
| Štúdium niektorých fyzikálnych procesov v systémoch obsahujúcich magnetické nanočastice v elektromagnetickom poli | |
| The study of some physical processes in systems containing magnetic nanoparticles in electromagnetic field | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.1.2006 – 31.12.2008 |