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| AZCAI – Anti-amyloidná aktivita kompozitov na báze zeolitov a analýza so zobrazovaním vo vysokom rozlíšení a v reálnom čase | |
| Anti-amyloid activity of zeolite-based composites and analysis with real-time 3d super-resolution imaging | |
| Program: | JRP |
| Project leader: | RNDr., Ing. Šipošová Katarína, PhD. |
| Annotation: | A common feature associated with most of neurodegenerative diseases, including Alzheimer’s disease is the formation of extended, β-sheet rich amyloid fibrils. Today, amyloid-related diseases are incurable and the treatment is only symptomatic without feasibility to stop or substantially delay the progressive consequences of the diseases. Magnetic nano/micro-particles based on clinoptilolite-type of natural zeolite (CZ) jointly developed are expected to serve synergistic therapy approaches act as carriers for controlled drug delivery/release, imaging and local heating in biological systems, that can effectively decompose the amyloid-like fibrillar structures. The micro and mesopores of the natural zeolite can serve as containers for delivering various drugs to the target site to release. Magnetic CZ (MCZs) will improve drug delivery process, real-time monitoring of drug distribution surrounding a targeting side of tissue, as well as the subsequent effects of the therapeutics on the progression of diseases. In addition, fluorescent MCZs in combination with ultrasonic, magnetic or laser irradiation effects will provide hyperthermia and photoreaction to achieve both diagnosis and therapy. The Taiwanese research team has been deeply cultivated in temporal focusing multiphoton microscopy (TFMPM), which imaging frame rate can achieve up to a hundred hertz. We will use the deep learning method to improve the imaging frame rate for real-time biomedical analysis. Within this project, animal models (including genetic rodent models) will be utilized to develop a theranostic system for for inhibition and destruction of amyloid aggregates and super-resolution imaging of MZC induced amyloid aggregate inhibition/destruction effects by state-of-art temporally and spatially super-resolution 3D imaging technology. |
| Duration: | 1.1.2022 – 31.12.2024 |
| AMAZON – Dynamické štúdium amyloidnej agregácie proteínov pomocou magnetických zeolitových nanočastíc | |
| – | |
| Program: | JRP |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.1.2018 – 31.12.2022 |
| FMF – Flexibilné magnetické vlákna: Vlastnosti a aplikácie | |
| Flexible Magnetic Filaments: Properties and Applications | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | Different technologies for synthesis of flexible magnetic filaments are developed. These include linking magnetic micro-particles by DNA, attaching magnetic nanoparticles to polyelectrolyte bundles, extraction of magnetosomes from magnetotactic bacteria and other. Flexible magnetic filaments are interesting for applications as self-propelling microdevices(for targeted transport), micro-mixers (for microfluidics), different sensors(micro rheology). Numerical algorithms for predicting their behavior in magnetic fields of different configurations will be developed, including algorithms based on curve dynamics, lattice Boltzmann method, Brownian dynamics. Obtained numerical results will be compared with experimental results of measurement of flows fields around magnetic filaments, their buckling instabilities. As a result new technology will be developed for DLS measurements giving access to characteristics of translation and rotational motion of string like magnetic micro-objects. |
| Duration: | 1.9.2018 – 31.12.2022 |
| NANOConVEX CIG – – Nanokvapaliny pre zariadenia na prenos tepla prúdením NANOConVEX CIG | |
| Nanofluids for convective heat transfer devices NANOConVEX CIG | |
| Program: | COST |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | In this project we would like to use the obtained results and experiences in application magnetic nanofluids prepared by our group in high power transformers with the intention of lowering of working temperature, increasing of heat dissipation from the transformer core at preservation its insulation characteristics. This fact will have the influence on the lifetime and lowering the cost reduction during the operation. |
| Duration: | 1.5.2020 – 30.4.2021 |
| MAGBBRIS – Nové magnetické biomateriály pre obnovu mozgu a zobrazovanie po mozgovej príhode | |
| New MAGnetic Biomaterials for Brain Repair and Imaging after Stroke | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | By engineering novel magnetic nano-biomaterials we will achieve tissue repair in the context of an ischemic event. We will take advantage of nanotechnology to deliver therapeutic growth factors, secreted by progenitor cells, into the injured brain.According to the World Health Organization, 15 million persons suffer a stroke worldwide eachyear. However, the only available treatment is the acute thrombolytic therapy (pharmacological or mechanical) which is being administered to less than 10% of stroke patients due to strict selectioncriteria. In contrast, neuro-repair treatments could offer the opportunity to include most strokepatients by extending the therapeutic time window.MAGBBRIS will demonstrate that growth factors, secreted by endothelial progenitor cells, with proved potential to induce tissue repair, can be encapsulated in magnetic biomaterials and be successfully and safely transplanted into mouse brains to induce tissue repair. In the ischemic brain, the secretome will be retained by an external magnetic field in the vasculature, improving vascular remodelling and neurogenic tissue regeneration after stroke. |
| Duration: | 1.3.2018 – 28.2.2021 |
| AMAZON – Dynamické štúdium amyloidnej agregácie proteínov pomocou magnetických zeolitových nanočastíc | |
| Dynamical study of formation/destruction of protein amyloid aggregatess targeted by magnetic zeolite nanocomposites | |
| Program: | JRP |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | Abnormal protein aggregation and accumulation of formed fibrils are characteristic features for a range of, if not all, neurodegenerative disorders such as Alzheimer’s, Huntington’s, Parkinson’s, as well as non-neuropathic amyloidosis. Nanoparticles (NPs), attributed to its particularities in sizes, chemical composition and surface properties, have already been found effective in influencing amyloid fibrils. Our preliminary results acquired on amyloid fibrils incubated with in-laboratory synthesized Fe3O4 nanoparticles (MNPs) indicated reductive potential of MNPs on formation of amyloid fibrils, and also suggested facilitation of inhibiting preformation and eradication of amyloid fibrils may be plausible when the fibrils are exposed to external radiation in presence of MNPs. Also, with our previously reported photoluminescence properties of natural zeolite (CZ) which is a promising material for biomedicine and pharmaceutics due to its non-toxicity, thermal stability, expanded surface area, and exceptional ability to adsorb various atoms, organic molecules and nanoparticles into micro- and mesopores, we plan to apply the MNPs with CZ, developing multiphoton excitation microscopy (MPEM), and other appropriate instruments to establish the dynamical investigation of amyloid fibril formation and remodeling in real time. Prior to in vivo experiment, cytotoxicity in different type of cells and animal models such as zebrafish and mice will be evaluated. |
| Duration: | 1.1.2018 – 31.12.2020 |
| Nanoradiomag – Vývoj a príprava rádionuklidmi značených magnetických nanočastíc dispergovaných vo vodnom prostredí. | |
| Development and production of water-dispersible radionuclide labeled magnetic nanoparticles | |
| Program: | EUREKA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Duration: | 1.1.2018 – 31.12.2020 |
| NANOUPTAKE – Prekonanie bariiér pre komerčné využitie nanokvapalín (NANOUPTAKE) | |
| Overcoming Barriers to Nanofluids Market Uptake ( NANOUPTAKE) | |
| Program: | COST |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | Nanofluids are defined as fluids that contain nanometre-sized particles with enhanced heat transfer properties. Nanofluids improve the efficiency of heat exchange and thermal energy storage. In addition, nanofluids fall within one of the Key Enabling Technologies (KET) supported by the European Commission. Although some nanofluid commercial applications currently exist, most of the current nanofluids are at Technological Readiness Levels (TRL) 1 to 3. Most of the nanofluids research in COST countries has been conducted by Research, Development and Innovation (R+D+i) centres through national funding. Additional coordinated research and development efforts are required to develop nanofluids up to higher TRL levels and to overcome commercial application barriers. If these barriers are overcome, nanofluids will be an important player in the Value Added Materials (VAM) for the energy sector.The objective of the NANOUPTAKE COST Action is to create a Europe-wide network of leading R+D+i institutions, and of key industries, to develop and foster the use of nanofluids as advanced heat transfer/thermal storage materials to increase the efficiency of heat exchange and storage systems. |
| Project webpage: | http://www.cost.eu/COST_Actions/ca/CA15119 |
| Duration: | 19.4.2016 – 18.4.2020 |
| BIOSAP – Nanoštrukturované bio-hybridné materiály generované samousporiadajúcimi procesmi | |
| Design of nanostructured bio-hybrid materials through self-assembly process | |
| Program: | Bilateral – other |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | The aim of the present project proposal is to significantly contribute to the better understanding of the complex interaction between magnetic nanoparticles and host matrix based on the lyotropic liquid crystal. One of the key tasks of the project herein is to prepare bio-inorganic hybrids based on liquid crystals formed by lysozyme fibrils alongside doping of magnetic nanoparticles, to study the interaction between magnetic nanoparticles and lysozyme amyloid fibrils as well as their consequential structure. The project proposal primarily targets experimental research on a phenomenon observed in biological anisotropic colloidal suspensions, which have been extensively studied for its consequential relation with many human neurodegenerative disorders such as Alzheimers disease, Hungtingtons disease, and etc. Self-assembly of colloidal nanomaterials makes it possible to obtain structures with high level of ordering and permit construction of patterns to be used in optoelectronics, photonics and biosensing. However, the exact principle of mechanisms and the nature of the phenomenon are still unknown, and represent unexplored areas of research. Various experimental techniques already available at the collaborating institutions as detailed below will be employed to attain the main objective of the project as well as the related objectives itemized in the proposal. |
| Duration: | 1.1.2018 – 31.12.2019 |
| SOOSA – Štúdium usporiadania, orientácie a samozbaľovania v biopolyméroch a kvapalných kryštáloch | |
| Study of orientation ordering and self-assembly in biopolymer and liquid crystal | |
| Program: | Bilateral – other |
| Project leader: | RNDr., Ing. Šipošová Katarína, PhD. |
| Annotation: | Liquid crystals (LCs) are matter in a state which has properties between those of conventional liquids and those of solid crystals. Examples of liquid crystals can be found both in the natural world and in technological applications. LCs actually exhibit a plethora of unique and attractive properties that offer tremendous potential for fundamental science as well as innovative applications depending on ordering properties of anisotropic molecules at interfaces in systems. In particular, new bio-nanocomposites consisting of protein amyloid fibrils (that can be consider as long and rigid objects similarly copolymers due to their stability and rigidity) and magnetic nanoparticles provide achievement of high special order and alignment. Within the project, we propose to focus on the effects of backbone-alignment on the ordering and self-assembly in these systems. |
| Duration: | 1.1.2018 – 31.12.2019 |
| Teoretické a experimentálne štúdium orientačných, magneto-optických a dielektrických vlastností kompozitov kvapalných kryštálov dopovaných magneticckými časticami. | |
| Theoretical and experimental studies of orientational, magneto-optical and dielectric properties of composite liquid crystals filled with magnetic particles. | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | At the last decades, one of the important areas of modern soft matter physics is theoretical and experimental study of liquid crystals (LC) which are very attractive for use in various commercial exploitations. The great interest of researchers to this area of science is explained, first of all, by fast development of electronic technique and communication equipments which require reliable, convenient and compact devices for processing and displaying information – indicators, displays, screens, etc. The successful use of LC materials in such devices considerably expanded a circle of technical applications of liquid crystals: now they are applied also in modern industrial machineries, in different transport vehicles and systems, medicine, household appliances, etc. Additionally, the search for new materials with exotic properties and for new technologies continues, in order to comply with the needs of these, and other novel applications. |
| Duration: | 1.1.2017 – 31.12.2019 |
| RADIOMAG – Multifunkcionalizované nanočastice pre magnetickú hypertermiu a nepriamu radiačnú | |
| Multifunctional Nanoparticles for Magnetic Hyperthermia and Indirect Radiation Therapy | |
| Program: | COST |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The Action aims to bring together and to organise the research outcomes from the different participating network members in a practical way to provide clinicians with the necessary input to trial a novel anti-cancer treatment combining magnetic hyperthermia and radiotherapy, also identifying future research objectives upon appraisal of the obtained results. Feedback between the different working groups here is essential, and is expected that the lifetime of this Action proposal will eventually result in a compendium of best practices for magnetic hyperthermia.RADIOMAG will generate new and strengthen the existing synergies between technical advances (thermal imaging / MH), new treatment concepts (combined targeting radiosensitisation and magnetic thermotherapy) and biocompatible coating in order to achieve a breakthrough in the clinical application of magnetic hyperthermia. Due to the complexity of this aim, synergies can only be achieved on a longer time frame, by means of workshops, STSMs, joint publications, common Horizon 2020 research proposals and exchange with other COST Actions (e.g. TD1004, TD1205). |
| Project webpage: | http://www.cost-radiomag.eu/ |
| Duration: | 13.11.2014 – 12.11.2018 |
| MAPACON – Magnetické vlastnosti anizotrópnych kompozitnych systémov | |
| Magnetic properties of anisotropic composite nanosystems | |
| Program: | Bilateral – other |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | The aim of the present project proposal will significantly contribute to the better understanding ofthe complex interaction between the liquid crystalline matrix and the nanoparticles inferronematics (nematics liquid crystals doped with magnetic nanoparticles). The investigationand understanding of the interaction will help to prepare composite systems with highersensitivity to external magnetic field. Our preliminary (unpublished) results, devoted to studyingof magnetic properties of ferronematics, indicate a clear signature of the phase transitions (boththe isotropic to nematic and the nematic to crystal phase) in the magnetic properties of thesecomposite nanosystems: the ac susceptibility changes substantially at temperatures which canbe associated with the phase transition temperatures. The effect has neither been observed inundoped nematic liquid crystals, nor in pure nanoparticle systems. Therefore, it is reasonable tosuppose that the effect originates from the interactions between the nanoparticles and the liquidcrystal host. However, the exact cause, and the nature of the phenomenon is still unknown andrepresents an unexplored area of research. |
| Duration: | 1.1.2015 – 31.12.2016 |
| MACOSYS – Magneticky aktívne anizotrópne kompozitne systémy | |
| Magnetically active anisotropic composite systems | |
| Program: | ERANET |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposal relates to basic research of anisotropic soft materials sensitive to magnetic fields. The targeted substances are composite materials, so called ferronematics (nematic liquid crystals (LCs) doped with spherical, rod-like, chain-like magnetite nanoparticles, or with carbon nanotubes functionalized with magnetite nanoparticles), and the cross-linked liquid crystalline polymers (elastomers) doped with nanoparticles. The key objectives are: (i) to measure the optical and dielectric responses of these materials to low magnetic fields; (ii) to explore which conditions influence these responses (e.g., bias magnetic field, pretilt, anchoring between the liquid crystal and nanoparticles); (iii) to contribute to the better understanding of the major problem in ferronematics (FNs): the aggregation process; (iv) to enhance the magnetic field induced phase transition temperature shift in a novel type of FNs; (v) to produce mesogenic cross-linked composites sensitive to magnetic fields. |
| Duration: | 1.9.2013 – 31.8.2016 |
| MAPACON – Magnetické vlastnosti anizotrópnych kompozitnych systémov | |
| Magnetic properties of anisotropic composite nanosystems | |
| Program: | Bilateral – other |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | The aim of the present project proposal will significantly contribute to the better understanding ofthe complex interaction between the liquid crystalline matrix and the nanoparticles inferronematics (nematics liquid crystals doped with magnetic nanoparticles). The investigationand understanding of the interaction will help to prepare composite systems with highersensitivity to external magnetic field. Our preliminary (unpublished) results, devoted to studyingof magnetic properties of ferronematics, indicate a clear signature of the phase transitions (boththe isotropic to nematic and the nematic to crystal phase) in the magnetic properties of thesecomposite nanosystems: the ac susceptibility changes substantially at temperatures which canbe associated with the phase transition temperatures. The effect has neither been observed inundoped nematic liquid crystals, nor in pure nanoparticle systems. Therefore, it is reasonable tosuppose that the effect originates from the interactions between the nanoparticles and the liquidcrystal host. However, the exact cause, and the nature of the phenomenon is still unknown andrepresents an unexplored area of research. |
| Duration: | 1.1.2015 – 31.12.2015 |
| – | |
| Nanoparticles in anisotropic soft matter | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | Liquid crystals and liquid crystalline polymers are anisotropic fluids, and as such they are in general responsive to external stimuli. However, because of the small value of the anisotropy of the diamagnetic susceptibility (~10-7), they require rather high magnetic fields for a measurable response. In an effort to enhance the magnetic susceptibility, the idea of doping with magnetic particles was theoretically introduced more than fourty years ago. The experimental confirmations of the idea followed shortly, however, the results have been mainly found unreproducible indicating that the colloids were not stable. The research on this topic (especially on ferronematics) has been intensified in the last decade, and a number of experimental evidences has been given for obtaining stable composite materials when the concentration of the magnetic nanoparticles is kept low enough. In a recent paper [Soft Matter 7, 4742 (2011)] an experimental confirmation has been given for a measurable optical response of a ferronematic already at magnetic field of about 0.01T. The observation of the response at such a low field is very important for construction of various magneto-optical devices. We expect that our proposed research will contribute to a better understanding of the physics of the anisotropic colloidal systems, which represents the first step in designing materials with improved magnetic properties, and helps to establish the knowledge base to utilize related future technologies. |
| Duration: | 1.1.2013 – 31.12.2015 |
| MAGIC – Magneticky aktívne anizotrópne kvapaliny | |
| Magneticlally active anisotropic fluids | |
| Program: | Bilateral – other |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Duration: | 1.2.2009 – 31.12.2010 |
National
| Magneticky modifikovaný textil | |
| Magnetically modified textiles | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.7.2023 – 30.6.2027 |
| NANOFLIT – Nano-funkcionalizácia kvapalín pre olejové transformátory | |
| Nano-functionalization of liquids for liquid-immersed transformers | |
| Program: | SRDA |
| Project leader: | RNDr. Rajňák Michal, PhD. |
| Annotation: | The current increase in electricity consumption and the greening of its distribution, together with the increase in the price of materials for the production of distribution transformers, represent a challenge for applied research in electric power engineering. The intention of the presented project is to respond to this challenge by functionalizing the current liquids used in electrical transformers in order to increase their cooling efficiency while maintaining or improving their dielectric and insulating properties. For this project, the liquids used in the distribution transformers of the manufacturer interested in this research will be selected. These are commercial liquids primarily based on liquefied natural gas, synthetic and natural esters. Based on current state of the art, the liquids will be functionalized by means of nanotechnologies and nanomaterials, which can significantly improve thermal conductivity, natural and thermomagnetic convection, and thus make the overall heat transport in the liquids more efficient. The functionalizing nanoadditives will be mainly made from carbon (fullerene, nanodiamond) and iron oxides or other ferromagnetic elements. The functionalized liquids will undergo laboratory measurements of physico-chemical, electrical, magnetic and thermal properties. Based on the analyzes of laboratory experiments and numerical simulations, nanofluids with the greatest potential for improving the thermal and insulating properties of the transformer will be selected. The selected nanofluids will be tested by the industrial partner (the customer of the research results) and applied in the selected distribution transformer. The transformer will be subjected to electrical and temperature rise tests. One can expect that the nanofunctionalization of the liquids will result in a lower operating temperature of the transformer, which can lead to an extension of the transformer service life and to the production of smaller transformers. |
| Duration: | 1.7.2023 – 30.6.2027 |
| Procesy samousporiadania v mäkkých hybridných zmesiach kvapalných kryštálov a nanočastíc | |
| Self-organization processes in soft hybrid mixtures of liquid crystals and nanoparticles | |
| Program: | VEGA |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | The proposal aims to approach the research of liquid crystals doped with nanoparticles of different kind from anovel perspective of the self-organization that has an indisputable importance covering all fields of naturalsciences, and has also a deep impact in social sciences. In such composite systems a subtle interplay amongthe nanoparticles, the self-assembling matrix and the topological defects commands the self-organizationprocess. We will focus on the electric/magnetic field induced self-organization in such systems experimentally on different length scales by investigating the processes in different phases, isotropic, nematic, cholesteric with the anticipation that our results can be exploited in applications such as guided material transport, magnetic/electric switches/sensors, chemical/biosensors, in microfluidic/lab-on-a-chip devices, etc. We are convinced that systematic studies in this topic may change fundamentally current knowledge. |
| Duration: | 1.1.2021 – 31.12.2024 |
| NANOELEN – Nanokvapaliny v elektrotechnike | |
| Nanofluids in Electrical Engineering | |
| Program: | SRDA |
| Project leader: | RNDr. Rajňák Michal, PhD. |
| Annotation: | The submitted project is oriented on research into nanofluids based on alternative cooling and insulating liquidmedia such as oils based on liquefied natural gas, natural esters and new types of transformer oils. We willprepare novel nanofluids based on these oils by dispersing magnetic nanoparticles, fullerenes, graphenenanoplatelets or carbon nanotubes. The purpose of the nanofluids preparation is to enhance the coolingeffectiveness of the liquid media. The nanofluids will be investigated from dielectric, insulating, magnetic andheat transfer properties point of view. Finally, their cooling effectiveness will be tested in loaded powertransformers. Therefore, the aim of this project is the development of advanced liquid media for cooling andinsulating in electrical engineering, the application of which will have a potential impact on electric power saving,electrical equipment service life and protection of the environment. |
| Duration: | 1.7.2019 – 30.6.2023 |
| MODEX – MODEX | |
| – | |
| Program: | Štrukturálne fondy EÚ Výskum a inovácie |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.1.2021 – 31.12.2022 |
| Makroskopicky anizotrópne kompozity na báze kvapalnych kryštálov a magnetických nanočastíc | |
| Macroscopic anisotropic composites based on liquid crystals and magnetic nanoparticles | |
| Program: | VEGA |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | The proposal targets basic research on composite materials consisting of liquid crystals and various magnetic nanoparticles. Combination of the anisotropic properties of liquid crystals with the magnetic properties of the nanoparticles results in composites with unique magnetic and optical properties that the component materials themselves do not possess. The proposed studies concentrate on the increase of the sensitivity of our composite soft matter materials (liquid state) to magnetic fields and prepare new materials having unique dielectric, magnetic and optical properties. The main goal of the proposal is to influence the sensitivity of these anisotropicsystems to external magnetic field by adding suitable magnetic nanoparticles and by this way make a step forward towards potential applications in various magneto-optical or dielectric devices as for example sensors of low magnetic fields or light shutter. |
| Duration: | 1.1.2017 – 31.12.2020 |
| MODEX – Modifikované (nano)textilné materiály pre zdravotnícke technológie | |
| – | |
| Program: | Štrukturálne fondy EÚ Výskum a inovácie |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.1.2017 – 31.12.2020 |
| MVISION – Nanočastice v anizotrópnych systémoch | |
| Nanoparticles in anisotropic systems | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposal is devoted to study complex anisotropic systems based on thermotropic as well as lyotropic(biological) liquid crystals. Liquid crystals represents the uniq state of matter, which is liquid but posses theanisotropic properties. The structuralization phenomena in such systems play key role in fundamental as well asin applied research. The main aim is to s influence the sensitivity of these anisotropic systems to externalmagnetic field, what will be done by adding suitable magnetic nanoparticles and open the way for theirapplications in magneto-optical devices. |
| Duration: | 1.7.2016 – 31.12.2020 |
| Interakcia magnetických kvapalín s elektromagnetickým poľom | |
| Interaction of magnetic fluids with electromagnetic field | |
| Program: | VEGA |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | The proposed project will be devoted to the study magnetic principle of heating mechanism – hyperthermia in magnetic nanoparticles systems in dependence on preparation process, size and size distribution and magnetic properties. Besides usually used biocompatible spherical anoparticles as a subjects of this proposal will be special prepared magnetosome and magnetoferritin containing spherical magnetite nanoparticles. The obtainedexperiences for achievement high specific heat power will enable the application magnetic nanoparticles at cancer treatment in biomedicine.We aim to investigate the shielding (absorption and reflection) effects of transformer oil based magnetic fluid.Besides the unique cooling and isolating properties, these magnetic fluids can be reliable shielding medium in electromagnetic devices as well. The research on radiation stability of MFs will address electromagnetic fields and another type radiation. |
| Duration: | 1.1.2016 – 31.12.2019 |
| GONanoplatform – Grafénová nanoplatforma na detekciu rakoviny | |
| Graphene-based nanoplatform for detection of cancer | |
| Program: | SRDA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | This project proposal reflects current technological progress and new opportunities in biomedical applications ofgraphene-based sensors. Our main goals include the design and development of a graphene oxidemultifunctional nanoplatform (GO-MFN) for the detection of tumor cells. In the first step, the development ofgraphene oxide nanoflakes of appropriate size functionalized by monoclonal antibody is planned. For sensingthe tumor cells, GO-MFN of 100 nm size able to interact with a single cell will be prepared. Magneticnanoparticles added to GO-MFN will enable the inspection of deep tissues by nuclear magnetic resonance. Thedegree of oxidation of GO, type of the functional groups, optimal functionalization with covalently boundmonoclonal antibodies and magnetic nanoparticles, are the most important technological steps. The analysis ofthe basic interactions related to tumor sensing will be conducted in vitro on 2D and 3D cell models up to theproof-of-principle stage that will be directly applicable to laboratory and preclinical testing. The GO-MFNinteraction with the cell membrane and with the cell interior will be analysed with subcellular resolution. Such anapproach will bring original knowledge and a detailed understanding of the tumor sensing process that isimportant for the optimization of the sensor sensitivity. Detection of biomolecules bound to GO-MFN will be addressed in real time by several techniques.The project is based on a complex multidisciplinary approach, ranging from physics and chemistry up tobiomedicine and combining excellent science and the most sophisticated nano and bio-engineering. Theinvolved partners possess key skills, infrastructure, antibodies and tumor models, and are highly motivated toreach the project goals. |
| Duration: | 1.7.2015 – 30.6.2019 |
| Citlivosť kvapalných kryštálov s nanočasticami na vonkajšie magnetické pole | |
| Sensitivity of liquid crystals containing nanoparticles to external magnetic field | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposed project will devoted to the study of composite systems of liquid crystal with nanoparticles mainly magnetic particles with the aim to change their sensitivity to external magnetic field. The object of such study will be new kind of liquid crystals with bent-core molecules as well as traditional calamitic liquid crystals with rod-like molecules. Also the influence of magnetic particles on the structural phase transition from isotropic to nematic phase in external magnetic field will be investigated. We suppose this structural transition will be induced by external magnetic field. Moreover, the response of the above mentioned composite systems to low magnetic field (up to 0.1T) will be investigated, which is important for the construction of various magneto-optical devices as for example maping of magnetic fields. |
| Duration: | 1.1.2013 – 31.12.2016 |
| Štrukturalizačné javy v samousporiadajúcich štruktúrach proteínov ovplyvňované nanočasticami | |
| Structure-forming phenomena in self-assembly structures of proteins influenced by nanoparticles | |
| Program: | VEGA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | The main goal of the project is to study and explain the interaction of nanoparticles with proteins. Particularlysearch of correlation among size, shape, surface charge and magnetic moment of the nanoparticles and theirability to influence the structuralization effects on proteins there will be found out. The study of structural changesand amyloid aggregation of proteins is very intensive in the last decade, from times of the discovery that a varietyof human disorders is associated with the presence of amyloid deposits in various tissues and organs. Theamyloid related diseases, including Alzheimer’s and Parkinson’s diseases, appear as a result of fail of protein’sfunction caused their incorrect folding or aggregation of protein molecules in to specific, highly organized selfassembly structures of proteins (protein amyloid aggregates). |
| Duration: | 1.1.2012 – 31.12.2015 |
| Dobudovanie infraštruktúry pre výskum nanosystémov s perspektívou využitia v technickej a medicínskej praxi | |
| – | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.10.2012 – 31.12.2014 |
| METAMYLC – Štrukturalizačné javy v systémoch s nanočasticami | |
| Structuralization phenomena in systems with nanoparticles | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The structuralization phenomena plays key role in fundamental as well as in applied research. The proposed project is devoted to the study of the influence of nanoparticles on the structuralization phenomena in various systems as well as on the structuralization of the nanoparticles alone. Some special kinds of nanoparticles will be prepared, which will be used for study these effects. The main aim is to study the influence of the nanoparticles on the structuralization phenomena in two different kind of systems as liquid crystalline mater and amyloid structures. In the first system the magnetic particles can increase the sensitivity of liquid crystals on an external magnetic field. In the amyloid structures the nanoparticles can significantly influence the amyloid aggregation of proteins, which is responsible for amyloid diseases as Alzheimher, Parkinson and Dibetes II The prepared nanoparticles will also be used to build their 3D structures (metamaterials), i.e. to create systems with unusual physical properties as for example negative reflection. |
| Duration: | 1.5.2011 – 31.10.2014 |
| NANOKOP – Edukačné centrum pre výskum a vývoj komplexných nanosystémov („ECVV – NANOKOP“) | |
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| Program: | Štrukturálne fondy EÚ Vzdelávanie |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.1.2012 – 31.12.2013 |
| MAGPOL – Magneto-optické vlastnosti polymérnych tenkých filmov | |
| Magneto-optic properties of polymer thin films | |
| Program: | SRDA |
| Project leader: | RNDr. Timko Milan, CSc. |
| Annotation: | The aim of this work is to develop magnetically textured magneto-optical thin films (less than 10 microns) with significant Faraday effect and without important attenuation for optical applications. The polymer thin films will be prepared by solidification of PVA polymer doped by magnetic nanoparticles of various shape (spherical, chains and nanorods) and structuralized in external magnetic field. The final goal of such films with non reciprocal effects is to develop optical applications such as integrated isolators and sensors, this long-term goal represents a great challenge. |
| Duration: | 1.1.2012 – 31.12.2013 |
| Výpočtové prístupy štúdia štruktúry, zbaľovania a interakcií biopolymérov | |
| Computational approaches to study structure, folding and interactions of biopolymers | |
| Program: | Podpora MVTS z prostriedkov SAV |
| Project leader: | RNDr. Kožár Tibor, CSc. |
| Annotation: | The PI of this research proposal (Dr. Chin-Kun Hu), CoPI of this proposal(Dr. Ming-Chya Wu), and their collaborators (including Dr. Shura Hayryan, and collaborators from Slovakia, Yerevan, Berlin, etc) have developed protein and computation packages SMMP (simple molecular mechanics for proteins), ARVO (to calculate volume and surface of macromolecules, including proteins, DNA, RNA, etc), and CAVE (to detect cavities of macromolecules and calculate surface area and volumes of cavities). The PI and collaborators also developed efficient combination of Wang-Landau Monte Carlo methods and transition matrix Monte-Carlo method for simulating proteins. They have also calculated three-dimensional (3D) structures of a large numbers of microRNA and will establish a website for such 3D structures.. The PI of the collaborative group in Slovakia, Dr. Tibor Kozar (Department of Biophysics, Institute of Experimental Physics, Slovak Academy of Sciences) is an expert on modeling of glycans and glycoproteins. In this proposal, we will continue to improve SMMP, ARVO, CAVE, microRNA molecular dynamics calculations, and will collobrate with Dr. Tibor Kozar’s group to study glycan and glycoproteins and amyloid aggregates. In addition, significant effort will be devoted to interaction studies of ligands with biomacromolecules nucleic acids and proteins with both, small ligands (potential drugs) as well as nanoparticles in order to target amyloid aggregation being this important for diseases (e.g. Alzheimer\’s disease). |
| Duration: | 1.1.2011 – 31.12.2013 |
| Centrum excelentnosti výkonových elektronických systémov a materiálov pre ich komponenty II | |
| Center of excellence for power electronics and their material components II | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | RNDr. Timko Milan, CSc. |
| Duration: | 30.9.2010 – 31.8.2013 |
| NMTE – Nové materiály a technológie pre energetiku | |
| New materials and technologies for energetics | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | Ing. Diko Pavel, DrSc., akademik US Slovenska |
| Annotation: | Aims o the project are:1. Technology of nanostructured bulk superconductors for energy storage2. Biological battery based on renewable biological products3. New trafo-steel modified by nanoparticles 4. Cooling and insulating medium based on magnetic fluid for high power transformers |
| Project webpage: | nmte.saske.sk |
| Duration: | 1.5.2010 – 30.4.2013 |
| Dobudovanie centra pre kooperatívne javy a fázové prechody v nanosystémoch s pespektívou využitia v nano- a biotechnológiách | |
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| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.4.2010 – 31.3.2013 |
| NANOFLUID – Centrum excelentnosti SAV – Nanokvapaliny | |
| Centre excelence of SAS – Nanofluids | |
| Program: | Centrá excelentnosti SAV |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | Centre of NANOFLUIDS is oriented to development of technology of nanoparticles, as are magnetic nanoparticles, coloid gold, nanotubes and their complex characterisation from with aspect to their magnetic and morphologic properties. The prepared nanoparticles will be funcionalised for applications in biomedicine, biotechnology and electrotechnical industry. In the case of biomedical applications the interaction of nanoparticles with biomacromolecules will be investigated, mostly with aspect of the nanohazard, drug targeting delivery, hyperthermia and treatment many human diseases as e.g. Alzheimer\’s diseases, etc. For technical applications the centre will investigate opportunity of application in LCD’s, sensors of magnetic field, as an insulated and cooling medium in high power transformers and converters, exploation multilayered nanotubes and fullerenes as electrodes in device that could converts sun energy into electricity. |
| Duration: | 1.2.2009 – 31.1.2013 |
| Vplyv rôznych nanočastíc na štruktúrne prechody vo feronematikách a na dielektricke vlastnosti magnetických kvapalín | |
| Influence of different nanoparticles on the structural transitions in ferronematics and dielectric properties of magnetic fluids | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposed project will be devoted to the study of some processes in composite systems containing nanoparticles, namely in magnetic fluids and liquid crystals. The first part of the project will be devoted to liquid crystals doped with magnetic nanoparticles of various shape (spherical, rod-like, chain-like) and different kind of nanoparticles (magnetite, CoZnFeO, as well as new attractive gold and silver particles) with aim to influence their dielectric and optical properties in external magnetic and electric fields. The second part of the project will be deal with the investigation of the dielectric properties, partialdischarges and the both DC and AC dielectric breakdown of novel transformer oil based magnetic fluids with same kind of particles as above mentioned, regarding to the possibility of their application in power transformers. |
| Duration: | 1.1.2009 – 31.12.2012 |
| Vývoj tecnologických postupov magnetických kvapalín pre biomedecínske účely | |
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| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.1.2010 – 30.6.2012 |
| Centrum excelentnosti výkonových elektronických systémov a materiálov pre ich komponenty | |
| Center of excellence for power electronics and their material components | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | RNDr. Timko Milan, CSc. |
| Duration: | 25.5.2009 – 24.5.2011 |
| Kooperatívne javy a fázové prechody v nanosystémoch s perspektívou využitia v nano- a biotechnológiách | |
| Centre of excelence: Cooperative phenomena and phase transitions in nanosystems with perspective applications in nano- and biotechnology | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 24.4.2009 – 31.3.2011 |
| Cielený transport protinádorových liečiv prostredníctvom magneticky značených nanosfér | |
| Targeted transport of anticancer drugs in magnetically labelled nanoparticles | |
| Program: | SRDA |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Annotation: | The objective of this project is the development and evaluation of new delivery systems (of anticancer drug using targeting mechanism of magnetic labelled polymeric carriers), for use as carriers of anticancer drugs using targeting mechanism. Biodegradable nanoparticles based on commercially available polymers loaded with selected anticancer drug(s) will be prepared and characterized with the purpose to enhance the amount of drug reaching target site, prolong circulation time and reduce side effects. The objective is to develop and evaluate new magnetic targeted nanoparticles to be localized in a certain region of the body by applying an external magnetic field. Methodologically the project solves the problem of nanoparticle preparation, drug loading of nanoparticles, encapsulation efficiency and anticancer activity of loaded nanoparticles in vitro and in vivo evaluation, construction and evaluation of target efficiency in animal models. New formulation will be evaluated for safety. |
| Duration: | 1.5.2006 – 1.7.2009 |
| Štúdium niektorých fyzikálnych procesov v systémoch obsahujúcich magnetické nanočastice v elektromagnetickom poli | |
| The study of some physical processes in systems containing magnetic nanoparticles in electromagnetic field | |
| Program: | VEGA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.1.2006 – 31.12.2008 |