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| SeNaTa – Magnetické nanoštruktúrne materiály schopné samozahrievania pre teranostické aplikácie | |
| Self-heating magnetic nanoconstructs for theranostic applications | |
| Program: | Bilateral – other |
| Project leader: | RNDr. Kubovčíková Martina , PhD. |
| Annotation: | Cancer is still one of the leading causes of death worldwide, therefore significant research and innovation efforts are still needed to find new materials and methods for better cancer diagnosis and treatment. Magnetic nanoparticles (MNPs) appear to be a very promising material for use in many medical fields, such as in nanosurgery they can be used to kill tumor cells by increasing drug concentration in target cells in combination with hyperthermia as well. The presented project is focused on the development of new nanoconstructs labeled by radionuclide as a potential theranostic agent for radiotherapy and diagnostics. The first step to achieve the desired goal will be the synthesis of nanoconstructs consisting of self-heating magnetic nanoparticles coated with various biocompatible substances, which will exhibit the desired bioactivity as well. The prepared nanoconstructs will be studied by several physicochemical methods, and their stability and suitability for magnetic hyperthermia, i.e. the ability to produce heat in an alternating magnetic field, will be monitored. In the second step, nanoconstructs with the best properties will be radiolabeled with therapeutic 177Lu and diagnostic 99mTh radionuclides to prepare radioactive nanoconstructs for dual therapy and diagnosis. In the next step, in vitro toxicity testing of nanoconstructs labeled with radionuclides will be performed. The prepared magnetic magnetic nanostructured materials labeled with radionuclides will contribute to the improvement of diagnostics and therapy of cancer diseases. The project is based on a complex multidisciplinary approach, from physics, chemistry to biochemistry and biomedicine. The involved partners possess key skills, infrastructure and are highly motivated to achieve the project goals. |
| Duration: | 1.7.2023 – 30.6.2025 |
| Relaxácia a fotoindukované javy v chalkogenidových sklách | |
| Relaxation and photoinduced phenomena in chalcogenide glasses | |
| Program: | Inter-governmental agreement |
| Project leader: | doc. RNDr. Flachbart Karol, DrSc., akademik US Slovenska |
| Duration: | 1.1.2015 – 31.12.2016 |
| Cryodef – Fyzikálne mechanizmy nízkoteplotnej plastickej deformácie a porušovania nových vysokopevných multikomponentých amorfných a vysokoentropických zliatin | |
| Physical Mechanisms of the Low Temperature Plastic Deformation and Failure of New High Strength Multicomponent Amorphous and High-Entropy Alloys | |
| Program: | Inter-governmental agreement |
| Project leader: | RNDr. Csach Kornel, CSc. |
| Duration: | 1.4.2015 – 31.12.2016 |
| Mechanické vlastnosti a prejavy porušenia vysokopevných nanokryštalických kovov pripravených metódou viacnásobnej plastickej deformácie pri teplotách 300 a 77 K. | |
| Mechanical properties and failure pecurarities of the high-strength nanocrystalline metals, processed by the method of severe plastic deformation at temperatures 300 and 77 K | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Csach Kornel, CSc. |
| Duration: | 1.1.2014 – 31.12.2016 |
| Mechanické vlastnosti objemných nanokryštalických a amorfných materiálov pri kryogénnych teplotách | |
| Mechanical properties of bulk nanocrystalline and amorphous materials at cryogenic temperatures. | |
| Program: | Inter-academic agreement |
| Project leader: | RNDr. Csach Kornel, CSc. |
| Annotation: | Establishment of physical mechanisms of plastic deformation in uniaxial compression and tension and also failure modes of bulk nanocrystalline alloys with fcc crystal lattice Ni-18%Fe and Pd-5%Au (10-30 nm grain size), nanocrystalline Zr with hcp crystal lattice (grain size of 100 nm) and the Zr57.4Cu17.9Ni13.4Al10.3Nb1 and the Zr65Al7.5Ni10Cu5Pd12.5 bulk amorphous alloys in the 300-4.2 К temperature interval |
| Duration: | 1.1.2011 – 31.12.2013 |
National
| Procesy samousporiadania v mäkkých hybridných zmesiach kvapalných kryštálov a nanočastíc | |
| Self-organization processes in soft hybrid mixtures of liquid crystals and nanoparticles | |
| Program: | VEGA |
| Project leader: | RNDr. Tomašovičová Natália, CSc. |
| Annotation: | The proposal aims to approach the research of liquid crystals doped with nanoparticles of different kind from anovel perspective of the self-organization that has an indisputable importance covering all fields of naturalsciences, and has also a deep impact in social sciences. In such composite systems a subtle interplay amongthe nanoparticles, the self-assembling matrix and the topological defects commands the self-organizationprocess. We will focus on the electric/magnetic field induced self-organization in such systems experimentally on different length scales by investigating the processes in different phases, isotropic, nematic, cholesteric with the anticipation that our results can be exploited in applications such as guided material transport, magnetic/electric switches/sensors, chemical/biosensors, in microfluidic/lab-on-a-chip devices, etc. We are convinced that systematic studies in this topic may change fundamentally current knowledge. |
| Duration: | 1.1.2021 – 31.12.2024 |
| NANOVIR – Nanočastice pre riešenie diagnosticko-terapeutických problémov s COVID-19 (NANOVIR) | |
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| Program: | Štrukturálne fondy EÚ Výskum a inovácie |
| Project leader: | Ing. Závišová Vlasta, PhD. |
| Project webpage: | https://websrv.saske.sk/uef/veda-a-vyskum/projekty-v-ramci-opvai/nanovir/ |
| Duration: | 3.3.2021 – 30.6.2023 |
| BIOVID-19 – Vývoj biomodelov pre zlepšenie hodnotenia účinnosti liekov a látok, ktoré majú potenciál pri liečbe COVID-19 (BIOVID-19) | |
| – | |
| Program: | Štrukturálne fondy EÚ Výskum a inovácie |
| Project leader: | Ing. Koneracká Martina, CSc. |
| Project webpage: | https://websrv.saske.sk/uef/veda-a-vyskum/projekty-v-ramci-opvai/biovid-19/ |
| Duration: | 29.6.2021 – 30.6.2023 |
| Deformácia metastabilných amorfných a kryštalických materiálov | |
| Deformation of metastable amorphous and crystalline materials | |
| Program: | VEGA |
| Project leader: | RNDr. Csach Kornel, CSc. |
| Duration: | 1.1.2018 – 31.12.2021 |
| MVISION – Nanočastice v anizotrópnych systémoch | |
| Nanoparticles in anisotropic systems | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The proposal is devoted to study complex anisotropic systems based on thermotropic as well as lyotropic(biological) liquid crystals. Liquid crystals represents the uniq state of matter, which is liquid but posses theanisotropic properties. The structuralization phenomena in such systems play key role in fundamental as well asin applied research. The main aim is to s influence the sensitivity of these anisotropic systems to externalmagnetic field, what will be done by adding suitable magnetic nanoparticles and open the way for theirapplications in magneto-optical devices. |
| Duration: | 1.7.2016 – 31.12.2020 |
| Mechanické vlastnosti a stabilita amorfných zliatin a nanorozmerných sústav | |
| Mechanical properties and stability of amorphous alloys and nanosized systems | |
| Program: | VEGA |
| Project leader: | RNDr. Csach Kornel, CSc. |
| Annotation: | The project is focused to solving some problems of plastic deformation and the processes of structural relaxation in amorphous metallic alloys. Analogies and differences in failure micromechanisms of strong defective structurecharacterized as amorphous, nanocrystalline or strong degenerated crystalline solid solution (in the case of highentropic alloys). |
| Duration: | 1.1.2014 – 31.12.2017 |
| PhysNet – Medzinárodné virtuálne laboratórium fyziky progresívnych materiálov – PhysNet | |
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| Program: | Štrukturálne fondy EÚ Vzdelávanie |
| Project leader: | RNDr. Juríková Alena, CSc. |
| Duration: | 1.9.2013 – 31.10.2015 |
| METAMYLC – Štrukturalizačné javy v systémoch s nanočasticami | |
| Structuralization phenomena in systems with nanoparticles | |
| Program: | SRDA |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | The structuralization phenomena plays key role in fundamental as well as in applied research. The proposed project is devoted to the study of the influence of nanoparticles on the structuralization phenomena in various systems as well as on the structuralization of the nanoparticles alone. Some special kinds of nanoparticles will be prepared, which will be used for study these effects. The main aim is to study the influence of the nanoparticles on the structuralization phenomena in two different kind of systems as liquid crystalline mater and amyloid structures. In the first system the magnetic particles can increase the sensitivity of liquid crystals on an external magnetic field. In the amyloid structures the nanoparticles can significantly influence the amyloid aggregation of proteins, which is responsible for amyloid diseases as Alzheimher, Parkinson and Dibetes II The prepared nanoparticles will also be used to build their 3D structures (metamaterials), i.e. to create systems with unusual physical properties as for example negative reflection. |
| Duration: | 1.5.2011 – 31.10.2014 |
| Vplyv štruktúrnych zmien na deformáciu a porušovanie amorfných a nanoštruktúrovaných zliatin. | |
| Influence of structural changes on deformation and failure of amorphous and nanostructured alloys | |
| Program: | VEGA |
| Project leader: | RNDr. Csach Kornel, CSc. |
| Annotation: | The project is focused to the problem of the structure, structural defects and micromechanisms of deformation of amorphous metallic alloys. The study of the failure of nanocrystalline alloys is based on analogies of failure conditions in disordered and nanocrystalline materials. |
| Duration: | 1.1.2011 – 31.12.2013 |
| Dobudovanie centra pre kooperatívne javy a fázové prechody v nanosystémoch s pespektívou využitia v nano- a biotechnológiách | |
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| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 1.4.2010 – 31.3.2013 |
| NANOFLUID – Centrum excelentnosti SAV – Nanokvapaliny | |
| Centre excelence of SAS – Nanofluids | |
| Program: | Centrá excelentnosti SAV |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Annotation: | Centre of NANOFLUIDS is oriented to development of technology of nanoparticles, as are magnetic nanoparticles, coloid gold, nanotubes and their complex characterisation from with aspect to their magnetic and morphologic properties. The prepared nanoparticles will be funcionalised for applications in biomedicine, biotechnology and electrotechnical industry. In the case of biomedical applications the interaction of nanoparticles with biomacromolecules will be investigated, mostly with aspect of the nanohazard, drug targeting delivery, hyperthermia and treatment many human diseases as e.g. Alzheimer\’s diseases, etc. For technical applications the centre will investigate opportunity of application in LCD’s, sensors of magnetic field, as an insulated and cooling medium in high power transformers and converters, exploation multilayered nanotubes and fullerenes as electrodes in device that could converts sun energy into electricity. |
| Duration: | 1.2.2009 – 31.1.2013 |
| Kooperatívne javy a fázové prechody v nanosystémoch s perspektívou využitia v nano- a biotechnológiách | |
| Centre of excelence: Cooperative phenomena and phase transitions in nanosystems with perspective applications in nano- and biotechnology | |
| Program: | EU Structural Funds Research & Development |
| Project leader: | doc. RNDr. Kopčanský Peter, CSc. |
| Duration: | 24.4.2009 – 31.3.2011 |
| Deformácia a lom amorfných a nanokryštalických kovov | |
| Deformation and failure of amorphous and nanocrystalline metals | |
| Program: | VEGA |
| Project leader: | RNDr. Csach Kornel, CSc. |
| Duration: | 1.1.2008 – 31.12.2010 |
| Deformácia a mechanizmy porušovania amorfných a nanokryštalických kovov | |
| Deformation and Failture Mechanisms in Amorphous and Nanocrystalline Metals | |
| Program: | VEGA |
| Project leader: | RNDr. Csach Kornel, CSc. |
| Duration: | 1.1.2005 – 31.12.2007 |