{"id":5463,"date":"2021-08-04T10:36:45","date_gmt":"2021-08-04T08:36:45","guid":{"rendered":"http:\/\/websrv.saske.sk\/uef\/?page_id=5463"},"modified":"2025-06-09T10:35:40","modified_gmt":"2025-06-09T08:35:40","slug":"biovid-19","status":"publish","type":"page","link":"https:\/\/websrv.saske.sk\/uef\/veda-a-vyskum\/projekty-v-ramci-opvai\/biovid-19\/","title":{"rendered":"BIOVID-19"},"content":{"rendered":"

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Inform\u00e1cie o Opera\u010dnom programe Integrovan\u00e1 infra\u0161trukt\u00fara 2014 \u2013 2020 n\u00e1jdete na www.opii.gov.sk<\/a><\/p>\n

V\u00fdvoj biomodelov pre zlep\u0161enie hodnotenia \u00fa\u010dinnosti liekov a l\u00e1tok, ktor\u00e9 maj\u00fa potenci\u00e1l pri lie\u010dbe COVID-19 (BIOVID-19) <\/strong><\/h2>\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n\n
E\u00da fond<\/strong><\/td>\nEur\u00f3psky fond region\u00e1lneho rozvoja<\/td>\n<\/tr>\n
V\u00fdzva <\/strong><\/td>\nPodpora mobiliz\u00e1cie a vyu\u017eitia potenci\u00e1lu v\u00fdskumn\u00fdch in\u0161tit\u00faci\u00ed pri boji proti pand\u00e9mii vyvolanej ochoren\u00edm COVID-19 a zni\u017eovan\u00ed negat\u00edvnych n\u00e1sledkov pand\u00e9mie<\/td>\n<\/tr>\n
K\u00f3d v\u00fdzvy<\/strong><\/td>\nOPII-VA\/DP\/2020\/9.4-01<\/td>\n<\/tr>\n
K\u00f3d projektu v ITMS2014+<\/strong><\/td>\n\u00a0313011AVG3<\/td>\n<\/tr>\n
N\u00e1zov projektu<\/strong><\/td>\nV\u00fdvoj biomodelov pre zlep\u0161enie hodnotenia \u00fa\u010dinosti liekov a l\u00e1tok, ktor\u00e9 maj\u00fa potenci\u00e1l pri lie\u010dbe COVID-19 (BIOVID-19) (pdf.plag\u00e1t projektu)<\/em><\/td>\n<\/tr>\n
Subjekt\/prij\u00edmate\u013e pomoci<\/strong><\/td>\nCentrum experiment\u00e1lnej medic\u00edny\u00a0 Slovenskej akad\u00e9mie vied<\/td>\n<\/tr>\n
Partner 1<\/strong><\/p>\n

Partner 2<\/strong><\/td>\n

Univerzita Komensk\u00e9ho v Bratislave<\/p>\n

\u00dastav experiment\u00e1lnej fyziky Slovenskej akad\u00e9mie vied<\/td>\n<\/tr>\n

Financovanie projektu<\/strong><\/td>\nCOV<\/td>\n4 213 211,38 EUR<\/td>\n<\/tr>\n
NFP<\/td>\n4 196 783,62EUR<\/td>\n<\/tr>\n
VZ<\/td>\n16 427,76 EUR<\/td>\n<\/tr>\n
Obdobie realiz\u00e1cie projektu<\/strong><\/td>\n06\/2021 \u2013 06\/2023<\/td>\n<\/tr>\n
Miesto realiz\u00e1cie projektu<\/strong><\/td>\nSR\/Trnavsk\u00fd\u00a0 kraj\/ Dobr\u00e1 voda<\/p>\n

SR\/Bratislavsk\u00fd kraj\/Bratislava – mestsk\u00e1 \u010das\u0165 Star\u00e9 Mesto<\/p>\n

SR\/Ko\u0161ick\u00fd kraj\/ Ko\u0161ice\u00a0 \u2013 mestsk\u00e1 \u010das\u0165 Sever<\/p>\n

SR\/Ko\u0161ick\u00fd kraj\/ Ko\u0161ice\u00a0 \u2013 mestsk\u00e1 \u010das\u0165 Juh<\/td>\n<\/tr>\n

Dom\u00e9na inteligentnej \u0161pecializ\u00e1cie<\/strong><\/td>\nZdravie obyvate\u013estva a zdravotn\u00edcke technol\u00f3gie<\/td>\n<\/tr>\n
Hlavn\u00e9 relevantn\u00e9 SK NACE odvetvie<\/strong><\/td>\nQ86 Ostatn\u00fd v\u00fdskum a experiment\u00e1lny v\u00fdvoj v oblasti pr\u00edrodn\u00fdch a technick\u00fdch vied. V\u00fdroba z\u00e1kladn\u00fdch farmaceutick\u00fdch v\u00fdrobkov a farmaceutick\u00fdch pr\u00edpravkov<\/td>\n<\/tr>\n
Funk\u010dn\u00e9 v\u00e4zby<\/strong><\/td>\nQ86 \u2013 Zdravotn\u00edctvo<\/td>\n<\/tr>\n
\u00a0<\/strong><\/td>\n<\/tr>\n
Predmet v\u00fdskumu
\n<\/strong><\/p>\n
    \n
  • Napriek tomu, \u017ee \u0161t\u00fadie s vakc\u00ednami proti COVID-19 s\u00fa v s\u00fa\u010dasnosti dobre rozpracovan\u00e9, st\u00e1le existuje naliehav\u00e1 potreba n\u00e1js\u0165 \u010fal\u0161ie terapeutick\u00e9 mo\u017enosti a to najm\u00e4 s cie\u013eom postihn\u00fa\u0165 komplik\u00e1cie vypl\u00fdvaj\u00face z v\u00edrusovej infekcie, najm\u00e4 dysregulovan\u00fa imunitn\u00fa odpove\u010f a syst\u00e9mov\u00e9 komplik\u00e1cie spojen\u00e9 s progresiou COVID-19.<\/li>\n
  • Cie\u013eom projektu je vyvin\u00fa\u0165 anim\u00e1lny model pre zlep\u0161enie hodnotenia \u00fa\u010dinnosti liekov identifikovan\u00fdch ako l\u00e1tky, ktor\u00e9 maj\u00fa potenci\u00e1l pri lie\u010dbe COVID-19, pri\u010dom sa vyu\u017eij\u00fa s\u00fa\u010dasn\u00e9 poznatky o tomto ochoren\u00ed, ale hlavne n\u00e1lezy z\u00edskan\u00e9 zo vzoriek pacientov, ktor\u00ed umreli v priamej
    \ns\u00favislosti s infekciou COVID-19.<\/li>\n
  • Na vyvinutom modeli bude testovan\u00e1 aktu\u00e1lne najvhodnej\u0161ia lie\u010dba a to formou klasick\u00e9ho pod\u00e1vania, alebo cie\u013eovo orientovan\u00e1 prostredn\u00edctvom vhodnej nanoenkapsul\u00e1cie.<\/li>\n
  • N\u00e1vrh projektu preto pozost\u00e1va zo \u0161tyroch aktiv\u00edt, pri\u010dom prv\u00e1 je venovan\u00e1 moderniz\u00e1cii laborat\u00f3ri\u00ed a doplneniu pr\u00edstrojov\u00e9ho vybavenia v Dobrej Vode, kde bud\u00fa prebieha\u0165 experiment\u00e1lne pr\u00e1ce. Druh\u00e1 aktivita zah\u0155\u0148a histologicko-morfologick\u00e9 anal\u00fdzy vzoriek, tretia v\u00fdvoj biomodelu ochorenia COVID-19, ako i testovaniu klasick\u00e9ho a nanoenkapsulovan\u00e9ho lie\u010diva a \u0161tvrt\u00e1 je zameran\u00e1 na nanoenkapsul\u00e1ciu potenci\u00e1lnych lie\u010div, predov\u0161etk\u00fdm kortikosteroidov.<\/li>\n
  • N\u00e1vrh projektu je zalo\u017een\u00fd na optim\u00e1lnom zlo\u017een\u00ed partnerov, dop\u013a\u0148aj\u00facej sa person\u00e1lnej a infra\u0161trukt\u00farnej kapacite a vyv\u00e1\u017eenej \u0161trukt\u00fare po\u017eadovan\u00fdch finan\u010dn\u00fdch prostriedkov.<\/li>\n
  • Projekt v priebehu rie\u0161enia poskytne kvalitn\u00e9 vedeck\u00e9 v\u00fdstupy, definovan\u00e9 formy v r\u00e1mci ochrany du\u0161evn\u00e9ho vlastn\u00edctva na medzin\u00e1rodnej \u00farovni, ako i nov\u00e9 pracovn\u00e9 miesta.<\/li>\n<\/ul>\n<\/td>\n<\/tr>\n
V\u00fdstup do praxe
\n<\/strong><\/p>\n
    \n
  • r\u00fdchle a bezpe\u010dn\u00e9 testovanie nov\u00fdch lie\u010div, ktor\u00e9 maj\u00fa potenci\u00e1l pri lie\u010dbe n\u00e1sledkov sp\u00f4soben\u00fdch pand\u00e9miou COVID-19<\/li>\n
  • zlep\u0161enie zdravotnej situ\u00e1cie ekonomicky akt\u00edvneho obyvate\u013estva a z\u00e1chrana \u017eivotov najohrozenej\u0161\u00edch skup\u00edn<\/li>\n
  • r\u00fdchlej\u0161\u00ed n\u00e1vrat chor\u00fdch do pracovn\u00e9ho procesu<\/li>\n
  • ur\u010denie markerov v\u00fdznamn\u00fdch pri v\u010dasnej diagnostike a lie\u010dbe d\u00f4sledkov COVID-19<\/li>\n
  • v\u00fdvoj produktov na b\u00e1ze nanotechnol\u00f3gi\u00ed<\/li>\n
  • identifik\u00e1cia mo\u017enost\u00ed vyu\u017eitia testovan\u00fdch lie\u010div v komplexnom pr\u00edstupe ku kardiovaskul\u00e1rnym, respira\u010dn\u00fdm a metabolick\u00fdm poruch\u00e1m<\/li>\n
  • eduka\u010dn\u00fd materi\u00e1l pri predklinick\u00fdch anal\u00fdzach<\/li>\n<\/ul>\n

     <\/p>\n

    V\u010faka podpore<\/strong> v r\u00e1mci opera\u010dn\u00e9ho programu V\u00fdskum a inov\u00e1cie<\/strong> pre projekt \u201e\u00a0 V\u00fdvoj biomodelov pre zlep\u0161enie hodnotenia \u00fa\u010dinosti liekov a l\u00e1tok, ktor\u00e9 maj\u00fa potenci\u00e1l pri lie\u010dbe COVID-19 (BIOVID-19)<\/strong>\u201c s k\u00f3dom OPII-VA\/DP\/2020\/9.4-01\u00a0 313011AVG3 spolufinancovan\u00fd zo zdrojov\u00a0 Eur\u00f3pskeho fondu region\u00e1lneho rozvoja<\/strong> vznikli nasledovn\u00e9 publik\u00e1cie:<\/p>\n

      \n
    • MIRKOVI\u010c, Marija – MILANOVI\u010c, Zorana – PERI\u010c, Marko – VRAJNE\u0160-DURI\u010c, Sanja – OGNJANOVI\u010c, Milo\u0161 – ANTI\u010c, Bratislav – KURAICA, Milorad – KRSTI\u010c, Ivan – KUBOV\u010c\u00cdKOV\u00c1, Martina – ANTAL, Iryna – SOBOTOV\u00c1, Radka – Z\u00c1VI\u0160OV\u00c1, Vlasta – JUR\u00cdKOV\u00c1, Alena – FABI\u00c1N, Martin – KONERACK\u00c1, Martina. Design and preparation of proline, tryptophan and poly-L-lysine functionalized magnetic nanoparticles and their radiolabeling with 131I and 177Lu for potential theranostic use. In International Journal of Pharmaceutics, 2022, vol. 628, art. no. 122288<\/li>\n
    • M. Gancar, E. Kurin, Z. Bednarikova, J. Mare1, P. Mucaji, M. Nagy and Z. Gazova: Influence of herbal extracts\u2019 constituents on the amyloid aggregation of protein, Book of Contributions – 10th Slovak Biophysical Symposium, Smolenice, 2022, SC20, s. 70<\/li>\n
    • A. Antosova, M. Gancar, E. Bystrenova, Z. Bednarikova, J. Marek and Z. Gazova: \u03b1-lactalbumin amyloid fibrillization in the presence of chloride salts cations, Book of Contributions – 10th Slovak Biophysical Symposium, Smolenice, 2022, PO23, s. 108-109<\/li>\n
    • Z. Bednarikova, E. Bystrenova, M. Barbalinardo and Z. Gazova: Protein amyloid self-assembly, polymorphism and biological significance: anion role, Book of Contributions – 10th Slovak Biophysical Symposium, Smolenice, 2022, PO24, s. 110-111<\/li>\n
    • D. Fedunova, M. Guncheva, V. Vanik, Z. Bednarikova, M. Gancar and Z. Gazova: Modulation of insulin amyloid aggregation by amino acid-based ionic liquids: anion role, Book of Contributions – 10th Slovak Biophysical Symposium, Smolenice, 2022, PO26, s. 114-115<\/li>\n
    • O. Parmar, A. Antosova, M. Gancar, Z. Bednarikova, E. Bystrenova, M. Kubovcikova, M. Koneracka, V. Zavisova and Z. Gazova: Amino acid-coated magnetite nanoparticles as potential inhibitors of \u03b1- lactalbumin amyloid aggregation, Book of Contributions – 10th Slovak Biophysical Symposium, Smolenice, 2022, PO27, s. 116-117<\/li>\n
    • Antal, M. Kubovcikova, M. Koneracka, V. Zavisova, A. Jurikova, I. Khmara, R. Sobotova: Novel Poly-L-Lysine Coated Nanoparticles in a Form of Magnetic Fluid Designed for Biomedical Applications, Book of Abstracts – The 6th International Conference on Nanomaterials: Fundamentals and Applications, \u0160trbsk\u00e9 Pleso, Smolenice, 2022, s. 23-24<\/li>\n
    • A. Jur\u00edkov\u00e1, I. Antal, I. Khmara, M. Konerack\u00e1, M. Kubov\u010d\u00edkov\u00e1, R. Sobotov\u00e1, V. Z\u00e1vi\u0161ov\u00e1: Thermogravimetric Analysis of Amino-modified Magnetic Nanoparticles, Book of Abstracts – The 6th International Conference on Nanomaterials: Fundamentals and Applications, \u0160trbsk\u00e9 Pleso, 2022, s. 75-77<\/li>\n
    • R. Sobotova, M. Koneracka, V. Zavisova, M. Kubovcikova, I. Antal, I. Khmara, O. Strbak, P. Mikolka: Engineered Nanoparticles for Imaging of Drug Distribution in Lungs by Magnetic Resonance, Book of Abstracts – The 6th International Conference on Nanomaterials: Fundamentals and Applications, \u0160trbsk\u00e9 Pleso, 2022, s. 122-123<\/li>\n
    • V. Z\u00e1vi\u0161ov\u00e1, M. Kubov\u010d\u00edkov\u00e1, I. Antal, I. Khmara, A. Jur\u00edkov\u00e1, R. Sobotov\u00e1, M. Konerack\u00e1: Nanocarriers as Drug Delivery Systems, Book of Abstracts – The 6th International Conference on Nanomaterials: Fundamentals and Applications, \u0160trbsk\u00e9 Pleso, 2022, s. 140-142<\/li>\n
    • Gancar M., Antosova A., Bednarikova Z., Marek J., Bystrenova E., Gazova Z.: Cations‘ influence on amyloid aggregation of \u03b1-lactalbumin, Abstract Book – 9th Scandinavian and Baltic Conference, Amyloid Diseases and Amyloid Mechanisms\u201c (ADAM 9), Riga, Loty\u0161sko, 2022, P15, s. 58<\/li>\n
    • Monika Tvrdonova, Barbora Borovska, Aneta Salayova, Robert Roncak, Peter Michalcin, Zuzana Bednarikova, Zuzana Gazova: Design and synthesis of novel carbohydrate-amino acid hybrids and their antioxidant and anti-\u03b2-amyloid aggregation activity, Bioorganic Chemistry 137 (2023) 106636<\/li>\n
    • Vladimir Vanik, Zuzana Bednarikova, Gabriela Fabriciova, Steven S.-S. Wang, Zuzana Gazova and Diana Fedunova: Modulation of Insulin Amyloid Fibrillization in Imidazolium-Based Ionic Liquids with Hofmeister Series Anions, Int. J. Mol. Sci. 2023, 24, 9699<\/li>\n
    • Miroslav Gancar, Elena Kurin, Zuzana Bednarikova, Jozef Marek, Pavel Mucaji, Milan Nagy, Zuzana Gazova; Green tea leaf constituents inhibit the formation of lysozyme amyloid aggregates: An effect of mutual interactions; International Journal of Biological Macromolecules, 2023, 242, 2, 124856<\/li>\n
    • Andrea Antosova, Olga Parmar, Patrizia Verducci, Eva Bystrenova, Miroslav Gancar, Iryna Antal, Martina Kubovcikova, Zuzana Bednarikova, Martina Koneracka, Vlasta Zavisova, Zuzana Gazova: Anti-amyloid activity of proline-, cysteine-, and poly-L-lysine functionalized, Book of Abstracts \u2013 16 th International Conference on Magnetic Fluids, Granada, Spain, 2023, LSA-PS1-14, s. 135<\/li>\n
    • \u00a0R. Sobotova, V. Zavisova, M. Kubovcikova, I. Antal, I. Khmara, O. Strbak, P. Mikolka, J. Gombos, M. Koneracka: Functionalized magnetic nanoparticles for MRI imaging of drug distribution in the lungs in experimental acute respiratory distress syndrome, Book of Abstracts \u2013 16 th International Conference on Magnetic Fluids, Granada, Spain, 2023, PP-PS2-12, s. 190<\/li>\n
    • \u00a0Iryna Antal, Andrea Antosova, Martina Kubovcikova, Zuzana Bednarikova, Martina Koneracka, Vlasta Zavisova, Alena Jur\u00edkov\u00e1, Iryna Khmara, Zuzana Gazova: Fabrication, characterization and bioactive properties of poly-L-lysine and chitosan functionalized magnetic nanoparticles, Book of Abstracts \u2013 16 th International Conference on Magnetic Fluids, Granada, Spain, 2023, S-PS2-3, s. 208<\/li>\n
    • \u00a0I. Khmara, M. Kubovcikova, I. Antal, A. Jurikova, V. Zavisova, M. Koneracka: Influence of coating on peroxidase-like activity of magnetic nanoparticles, Book of Abstracts \u2013 16 th International Conference on Magnetic Fluids, Granada, Spain, 2023, S-PS2-5, s. 210<\/li>\n<\/ul>\n

      Zoznam publik\u00e1ci\u00ed vytvoren\u00fdch v r\u00e1mci projektu V\u00fdvoj biomodelov pre zlep\u0161enie hodnotenia \u00fa\u010dinnosti liekov a l\u00e1tok, ktor\u00e9 maj\u00fa potenci\u00e1l pri lie\u010dbe COVID-19 (BIOVID-19)<\/strong> partner: \u00dastav experiment\u00e1lnej fyziky SAV, v. v. i.
      \nv 1. n\u00e1slednom monitorovanom obdob\u00ed 1.7.2023 \u2013 10.4.2025\u00a0 \u00a0(.pdf)<\/a><\/td>\n<\/tr>\n<\/tbody>\n<\/table>\n","protected":false},"excerpt":{"rendered":"

      Inform\u00e1cie o Opera\u010dnom programe Integrovan\u00e1 infra\u0161trukt\u00fara 2014 \u2013 2020 n\u00e1jdete na www.opii.gov.sk V\u00fdvoj biomodelov pre zlep\u0161enie hodnotenia \u00fa\u010dinnosti liekov a l\u00e1tok, ktor\u00e9 maj\u00fa potenci\u00e1l pri…<\/p>\n","protected":false},"author":1,"featured_media":0,"parent":3957,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"footnotes":""},"_links":{"self":[{"href":"https:\/\/websrv.saske.sk\/uef\/wp-json\/wp\/v2\/pages\/5463"}],"collection":[{"href":"https:\/\/websrv.saske.sk\/uef\/wp-json\/wp\/v2\/pages"}],"about":[{"href":"https:\/\/websrv.saske.sk\/uef\/wp-json\/wp\/v2\/types\/page"}],"author":[{"embeddable":true,"href":"https:\/\/websrv.saske.sk\/uef\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/websrv.saske.sk\/uef\/wp-json\/wp\/v2\/comments?post=5463"}],"version-history":[{"count":19,"href":"https:\/\/websrv.saske.sk\/uef\/wp-json\/wp\/v2\/pages\/5463\/revisions"}],"predecessor-version":[{"id":9162,"href":"https:\/\/websrv.saske.sk\/uef\/wp-json\/wp\/v2\/pages\/5463\/revisions\/9162"}],"up":[{"embeddable":true,"href":"https:\/\/websrv.saske.sk\/uef\/wp-json\/wp\/v2\/pages\/3957"}],"wp:attachment":[{"href":"https:\/\/websrv.saske.sk\/uef\/wp-json\/wp\/v2\/media?parent=5463"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}